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REVIEW
Persefoni Fragkiadaki, Elisavet Kouvidi, Anna Angelaki, Dimitra Nikolopoulou, Elena Vakonaki, Aristidis Tsatsakis
The current article is a literature review aiming to provide an overview of the existing knowledge on the association between telomere length and telomerase activity and in vitro fertilization. Recently, telomeres have been used as an effective biomarker to determine biological age, which may differ from chronological age due to genetic, lifestyle, and environmental factors. Cellular senescence, along with other exogenous and mainly environmental factors, can enhance telomere wear, further shortening their ends and may also affect reproductive aging...
May 2, 2024: Journal of Assisted Reproduction and Genetics
#22
REVIEW
Isabela Peña Pino, Emily Fellows, Robert A McGovern, Clark C Chen, Carolina Sandoval-Garcia
Optimizing the treatment of hydrocephalus remains a major challenge in adult and pediatric neurosurgery. Currently, clinical treatment relies heavily on anatomic imaging of ventricular size and clinical presentation. The emergence of functional and structural brain connectivity imaging has provided the basis for a new paradigm in the management of hydrocephalus. Here we review the pertinent advances in this field. Following PRISMA-ScR guidelines for scoping reviews, we searched PubMed for relevant literature from 1994 to April 2023 using hydrocephalus and MRI-related terms...
May 2, 2024: Neurosurgical Review
#23
REVIEW
Alessandra Boschi, Luca Urso, Licia Uccelli, Petra Martini, Luca Filippi
BACKGROUND: In recent years, fibroblast activating protein (FAP), a biomarker overexpressed by cancer-associated fibroblasts, has emerged as one of the most promising biomarkers in oncology. Similarly, FAP overexpression has been detected in various fibroblast-mediated inflammatory conditions such as liver cirrhosis and idiopathic pulmonary fibrosis. Along this trajectory, FAP-targeted positron emission tomography (PET), utilizing FAP inhibitors (FAPi) labeled with positron emitters, has gained traction as a powerful imaging approach in both cancer and inflammation...
May 2, 2024: EJNMMI Radiopharmacy and Chemistry
#24
JOURNAL ARTICLE
Fuguang Zhao, Zhibo Jia, Hui Xie
PURPOSE: Individualized medicine has become increasingly important in bladder cancer treatment, whereas useful biomarkers for prognostic prediction are still lacking. The current study, therefore, constructed a novel risk model based on pyroptosis- and immune-related long noncoding RNAs (Pyro-Imm lncRNAs) to evaluate the potential prognosis of bladder cancer. METHODS: Corresponding data of bladder cancer patients were downloaded from the Cancer Genome Atlas (TCGA) database...
May 2, 2024: Discover. Oncology
#25
JOURNAL ARTICLE
Yue Ba, Zichen Feng, Xiaoli Fu, Ruiqin Chen, Xuecheng Jiao, Yuhui Du, Xiaoxue Liu, Hui Huang, Fangfang Yu, Guoyu Zhou
Excessive fluoride can adversely affect bone mineral density (BMD). Oxidative stress and mitochondrial dysfunction are crucial mechanisms of health damage induced by fluoride. Here, a cross-sectional survey involving 907 Chinese farmers (aged 18-60) was carried out in Tongxu County in 2017, aiming to investigate the significance of mitochondrial DNA copy number (mtDNAcn) and oxidative stress in fluoride-related BMD change. Concentrations of urinary fluoride (UF), serum oxidative stress biomarkers, including total antioxidant capacity (T-AOC), total superoxide dismutase (T-SOD), glutathione peroxidase (GSH-Px), and malondialdehyde (MDA), as well as relative mtDNAcn in peripheral blood were determined...
May 2, 2024: Environmental Geochemistry and Health
#26
JOURNAL ARTICLE
Jacob Allen Miller, Zhiwei Liu, Benjamin A Pinsky, Quynh-Thu Le, Tong Li, Kelly J Yu, Allan Hildesheim, Su-Mei Cao
BACKGROUND: Screening with anti-Epstein-Barr Virus (EBV) serology and endoscopy decreased nasopharyngeal carcinoma (NPC) mortality in Guangdong in a randomized trial. We conducted a secondary analysis of this trial using local incidence and cost data to optimize screening programs, hypothesizing that screening could be cost-effective in southern China. METHODS: Screening costs and life-years after NPC diagnosis were obtained from the Guangdong trial's intent-to-screen population (men and women age 30-69)...
May 2, 2024: Cancer Epidemiology, Biomarkers & Prevention
#27
JOURNAL ARTICLE
Alice N Weaver, Wade T Iams, Jong Chul Park, Monica Mita, Udo Holtick, Michael S Gordon, Kerry J Rodabaugh, Neesha Dhani, Prakash Neupane, Matthew Taylor, E Amanda Duvall, Julia Jennings, Nathan R Miselis, Scott Loughhead, Marshelle S Warren, Howard Bernstein, Jens P Klussmann, Joaquina Baranda, Antonio Jimeno
Cancer vaccines strive to induce robust, antigen-targeted, T-cell-mediated immune responses but have struggled to produce meaningful regression in solid tumors. An autologous cell vaccine, SQZ-PBMC-HPV, was developed by SQZ Biotechnologies using microfluidic squeezing technology to load PBMCs with HPV16 E6 and E7 antigens in HLA-A*02+ patients. The SQZ-PBMC-HPV-101 Phase 1 trial (NCT04084951) enrolled patients with incurable HPV16+ cancers. Here, we present a post hoc analysis of the relationship between Posttreatment CD8+ T cell infiltration and patient outcomes...
May 2, 2024: Molecular Carcinogenesis
#28
JOURNAL ARTICLE
Harun Coban, Dilek Barutcu Atas, Murat Tugcu, Meltem Kursun, Canan Cimsit, Ebru Asicioglu, Hakki Arikan, Serhan Tuglular, Arzu Velioglu
OBJECTIVES: Sarcopenia is common in chronic kidney disease and associated with increased mortality. We investigated the prevalence of sarcopenia, defined as low muscle mass by the psoas muscle index, in endstage renal disease patients on waiting lists for kidney transplant and determined its association with prognostic nutritional index, C-reactive protein-toalbumin ratio, cardiovascular events, and mortality. MATERIALS AND METHODS: Our study included 162 patients with end-stage renal disease and 87 agematched healthy controls...
March 2024: Experimental and Clinical Transplantation
#29
JOURNAL ARTICLE
Justin Z Wang, Alexander P Landry, David R Raleigh, Felix Sahm, Kyle M Walsh, Roland Goldbrunner, Leeor S Yefet, Jörg C Tonn, Chloe Gui, Quinn T Ostrom, Jill Barnholtz-Sloan, Arie Perry, Yosef Ellenbogen, C Oliver Hanemann, Gerhard Jungwirth, Michael D Jenkinson, Ghazaleh Tabatabai, Tiit I Mathiesen, Michael W McDermott, Marcos Tatagiba, Christian la Fougère, Sybren L N Maas, Norbert Galldiks, Nathalie L Albert, Priscilla K Brastianos, Felix Ehret, Giuseppe Minniti, Katrin Lamszus, Franz L Ricklefs, Jens Schittenhelm, Katharine J Drummond, Ian F Dunn, Omar N Pathmanaban, Aaron Cohen-Gadol, Erik P Sulman, Emeline Tabouret, Emelie Le Rhun, Christian Mawrin, Jennifer Moliterno, Michael Weller, Wenya Linda Bi, Andrew Gao, Stephen Yip, Maximilian Niyazi, Kenneth Aldape, Patrick Y Wen, Susan Short, Matthias Preusser, Farshad Nassiri, Gelareh Zadeh
Meningiomas are the most common primary intracranial tumors in adults and are increasing in incidence due to the aging population and the rising availability of neuroimaging. While most exhibit non-malignant behaviour, a subset of meningiomas are biologically aggressive and lead to significant neurological morbidity and mortality. In recent years, meaningful advances in our understanding of the biology of these tumors have led to the incorporation of molecular biomarkers into their grading and prognostication...
May 2, 2024: Neuro-oncology
#30
JOURNAL ARTICLE
Kheibar Dashtian, Fatemeh Afshar Gheshlaghi, Rouholah Zare-Dorabei, Mohammad Mahdavi
Septicemia, a severe bacterial infection, poses significant risks to human health. Early detection of septicemia by tracking specific biomarkers is crucial for a timely intervention. Herein, we developed a molecularly imprinted (MI) TiO2 -Fe-CeO2 nanozyme array derived from Ce[Fe(CN)6 ] Prussian blue analogues (PBA), specifically targeting valine, leucine, and isoleucine, as potential indicators of septicemia. The synthesized nanozyme arrays were thoroughly characterized using various analytical techniques, including Fourier transform infrared spectroscopy, X-ray diffraction, field-emission scanning electron microscope, and energy-dispersive X-ray...
May 2, 2024: ACS Applied Bio Materials
#31
JOURNAL ARTICLE
Laura Durbin, Bhavna Murali, Song Li, Stephanie Hawthorne, Otávio Clark
Aim: To report the treatment patterns of advanced/metastatic non-small-cell lung cancer (NSCLC) in China from a physician survey (CancerMPact® ). Materials & methods: A total of 206 Chinese physicians from 27 cities in urban mainland China reported on their treatment of NSCLC in September 2021. Results: Platinum doublets received 70.5% utilization for squamous NSCLC with PD-L1 expression <1% in first-line, whereas nonsquamous NSCLC was treated with platinum doublets (35.2%) or bevacizumab with platinum doublets (35...
May 2, 2024: Future Oncology
#32
JOURNAL ARTICLE
Faysal Şaylık, Tufan Çınar, İbrahim Halil Tanboğa
BACKGROUND: No-reflow (NR) is characterized by an acute reduction in coronary flow that is not accompanied by coronary spasm, thrombosis, or dissection. Inflammatory prognostic index (IPI) is a novel marker that was reported to have a prognostic role in cancer patients and is calculated by neutrophil/lymphocyte ratio (NLR) multiplied by C-reactive protein/albumin ratio. OBJECTIVE: We aimed to investigate the relationship between IPI and NR in ST-segment elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention (pPCI)...
2024: Arquivos Brasileiros de Cardiologia
#33
MULTICENTER STUDY
Andreia Palma, Pedro A Sousa, Carolina Saleiro, Sérgio Barra, Natália António, Luis Adão, João Primo, Ana Lebreiro, Paulo Fonseca, Luís Elvas, Lino Gonçalves
BACKGROUND: Ablation Index (AI) software has allowed better atrial fibrillation (AF) ablation results, but recurrence rates remain significant. Specific serum biomarkers have been associated with this recurrence. OBJECTIVES: To evaluate whether certain biomarkers could be used (either individually or combined) to predict arrhythmia recurrence after AI-guided AF ablation. METHODS: Prospective multicenter observational study of consecutive patients referred for AF ablation from January 2018 to March 2021...
2024: Arquivos Brasileiros de Cardiologia
#34
EDITORIAL
Nelson Americo Hossne Junior
No abstract text is available yet for this article.
2024: Arquivos Brasileiros de Cardiologia
#35
EDITORIAL
Carlos Henrique Miranda
No abstract text is available yet for this article.
2024: Arquivos Brasileiros de Cardiologia
#36
REVIEW
Brendan Khong, Salvatore Ferlito, Stuart Quek, Gianluca Conte, Angelo Ingrassia, Jerome Rene Lechien, Carlos Chiesa-Estomba, Miguel Mayo, Antonino Maniaci, Thomas Radulesco, Justin Michel, Nicolas Fakhry, Riccardo Polosa
Objectives: To provide an in-depth analysis of noninvasive methods for the early diagnosis of oral premalignant lesions, focusing on novel biomarkers and optical technologies, and to discuss their potential in improving the prognosis of patients with oral oncological diseases. Methods: This state-of-the-art review examines various noninvasive diagnostic techniques, including the utilization of salivary microRNAs and optical technologies such as Raman spectroscopy, elastic scattering spectroscopy, diffuse reflectance spectroscopy, narrow-band imaging, autofluorescence imaging, toluidine blue staining, and microendoscopy...
May 2, 2024: Ear, Nose, & Throat Journal
#37
JOURNAL ARTICLE
Jeanny H Wang, Charles S Rabkin, Eric A Engels, Minkyo Song
Eosinophils exhibit anti-tumor cytotoxic responses in the tumor microenvironment and may contribute to tumor immunosurveillance. To assess the relationship between circulating eosinophils and cancer risk, we analyzed data from 443,542 adults aged 38-73 in the UK Biobank, who were initially cancer-free, had over a year of follow-up, and baseline white blood cell count measurements. Using multivariable Cox regression, we estimated hazard ratios (aHR) and 95% confidence intervals (95%CI) for each quartile increase in absolute eosinophil count (AEC) across 58 cancer types, adjusting for relevant confounders...
May 2, 2024: International Journal of Cancer. Journal International du Cancer
#38
JOURNAL ARTICLE
Yves Iradukunda, Jing-Yan Kang, Xiao-Bo Zhao, Xiao-Kang Fu, Stanislas Nsanzamahoro, Wei Ha, Yan-Ping Shi
β-Galactosidase (β-Gala) is an essential biomarker enzyme for early detection of breast tumors and cellular senescence. Creating an accurate way to monitor β-Gala activity is critical for biological research and early cancer detection. This work used fluorometric, colorimetric, and paper-based color sensing approaches to determine β-Gala activity effectively. Via the sensing performance, the catalytic activity of β-Gala resulted in silicon nanoparticles (SiNPs), fluorescent indicators obtained via a one-pot hydrothermal process...
May 2, 2024: ACS Applied Bio Materials
#39
JOURNAL ARTICLE
Yanwei You
This study aimed to investigate the association between physical activity, sedentary behaviour and chronic inflammation in short sleep adults. The study included 2,113 NHANES participants with self-reported insufficient sleep. C-reactive protein (CRP) was used as the inflammatory biomarker. Physical activity and sedentary behaviour were objectively measured by accelerometers. Weighted regression model, two - piecewise linear regression model, and restricted cubic splines were applied to evaluate associations mentioned above...
May 2, 2024: Journal of Sports Sciences
#40
JOURNAL ARTICLE
Xiuping Lin, Chang-Sheng Shao, Shereen M Elsherbiny, Qing Huang
Astaxanthin (AST) is a xanthophyll carotenoid with strong oxidation resistance, which can effectively scavenge various free radicals and protect organisms from oxidative damage. AST is also known to have prominent anti-aging effects, but the underlying mechanism of AST in anti-radiation aging is largely unknown. In this work, we applied ultraviolet (UV) irradiation to accelerate the aging of Caenorhabditis elegans (C. elegans) and treated the nematodes with AST to explore whether and how AST could attenuate the radiation-induced aging effect...
May 2, 2024: Photochemistry and Photobiology
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