Honghui Jiang, Jianming Li, Yuanyuan Kong, Lili Song, Jing Liu, Deling Kong, Yongjian Wu, Shengzhang Wang, Zhihong Wang
Transcatheter aortic valve replacement (TAVR) has emerged as an effective therapy for inoperable patients with severe aortic stenosis (AS). However, calcification-induced limited durability restricts its application. Fish swim bladders (FSB), which are resistant to calcific degeneration, offer a viable solution to this challenge. In this study, we developed a new TAVR device using FSB as the valve leaflet. Furthermore, the in vitro durability, in vivo performance, and size selection of this TAVR device were assessed by an experimental study and finite element analysis...
April 23, 2024: Acta Biomaterialia