Hongwei Yu, Bin Pan, Andy Weyer, Hsiang-En Wu, Jingwei Meng, Gregory Fischer, Daniel Vilceanu, Alan R Light, Cheryl Stucky, Frank L Rice, Andy Hudmon, Quinn Hogan
UNLABELLED: The sensation of touch is initiated when fast conducting low-threshold mechanoreceptors (Aβ-LTMRs) generate impulses at their terminals in the skin. Plasticity in this system is evident in the process of adaption, in which a period of diminished sensitivity follows prior stimulation. CaMKII is an ideal candidate for mediating activity-dependent plasticity in touch because it shifts into an enhanced activation state after neuronal depolarizations and can thereby reflect past firing history...
October 21, 2015: Journal of Neuroscience