Yating Wang, Hongyu Li, Simin Jiang, Dongying Fu, Xiaohui Lu, Miaoqing Lu, Yi Li, Dan Luo, Kefei Wu, Yiping Xu, Guanglan Li, Yi Zhou, Yiming Zhou, Wei Chen, Qinghua Liu, Haiping Mao
Persistently elevated glycolysis in kidney has been demonstrated to promote chronic kidney disease (CKD). However, the underlying mechanism remains largely unclear. Here, we observed that 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3), a key glycolytic enzyme, was remarkably induced in kidney proximal tubular cells (PTCs) following ischemia-reperfusion injury (IRI) in mice, as well as in multiple etiologies of patients with CKD. PFKFB3 expression was positively correlated with the severity of kidney fibrosis...
May 22, 2024: Kidney International