Fumiko Tomiyama, Takaya Suzuki, Tatsuaki Watanabe, Jun Miyanaga, Anna Suzuki, Takayasu Ito, Sho Murai, Yuyo Suzuki, Hiromichi Niikawa, Hisashi Oishi, Hirotsugu Notsuda, Yui Watanabe, Takashi Hirama, Ken Onodera, Takeo Togo, Masafumi Noda, Thomas K Waddell, Golnaz Karoubi, Yoshinori Okada
Whole lung engineering and the transplantation of its products is an ambitious goal and ultimately a viable solution for alleviating the donor-shortage crisis for lung transplants. There are several limitations currently impeding progress in the field with a major obstacle being efficient revascularization of decellularized scaffolds, which requires an extremely large number of cells when using larger pre-clinical animal models. Here, we developed a simple but effective experimental pulmonary bioengineering platform by utilizing the lung as a scaffold...
April 4, 2024: Scientific Reports