Charlotte Hateley, Antoni Olona, Laura Halliday, Matthew L Edin, Jeong-Hun Ko, Roberta Forlano, Ximena Terra, Fred B Lih, Raúl Beltrán-Debón, Penelopi Manousou, Sanjay Purkayastha, Krishna Moorthy, Mark R Thursz, Guodong Zhang, Robert D Goldin, Darryl C Zeldin, Enrico Petretto, Jacques Behmoaras
BACKGROUND: Obesity drives maladaptive changes in the white adipose tissue (WAT) which can progressively cause insulin resistance, type 2 diabetes mellitus (T2DM) and metabolic dysfunction-associated liver disease (MASLD). Obesity-mediated loss of WAT homeostasis can trigger liver steatosis through dysregulated lipid pathways such as those related to polyunsaturated fatty acid (PUFA)-derived oxylipins. However, the exact relationship between oxylipins and metabolic syndrome remains elusive and cross-tissue dynamics of oxylipins are ill-defined...
April 26, 2024: EBioMedicine