Snezana Tepavcevic, Snjezana Romic, Manja Zec, Tijana Culafic, Mojca Stojiljkovic, Tamara Ivkovic, Marija Pantelic, Milan Kostic, Jelena Stanisic, Goran Koricanac
The transport of cations in the cardiomyocytes, crucial for the functioning of the heart, can be affected by walnut diet due to the high content of polyunsaturated fatty acids. Healthy and metabolically compromised rats (drinking 10% fructose solution) were subjected to a diet supplemented with 2.4 g of walnuts for 6 weeks to investigate the effect on proteins involved in cation transport in the heart cells. Fructose increased the level of the α 1 subunit of Na+ /K+ -ATPase and the phosphorylation of extracellular signal-regulated kinase 1/2 in the heart of control and walnut-eating rats, while elevated L-type calcium channel α (LTCC α ), sodium-calcium exchanger 1 (NCX1), and Maxi K α level were observed only in rats that did not consume walnuts...
November 2023: Journal of Medicinal Food