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JOURNAL ARTICLE
JoAnn E Manson, Carolyn J Crandall, Jacques E Rossouw, Rowan T Chlebowski, Garnet L Anderson, Marcia L Stefanick, Aaron K Aragaki, Jane A Cauley, Gretchen L Wells, Andrea Z LaCroix, Cynthia A Thomson, Marian L Neuhouser, Linda Van Horn, Charles Kooperberg, Barbara V Howard, Lesley F Tinker, Jean Wactawski-Wende, Sally A Shumaker, Ross L Prentice
IMPORTANCE: Approximately 55 million people in the US and approximately 1.1 billion people worldwide are postmenopausal women. To inform clinical practice about the health effects of menopausal hormone therapy, calcium plus vitamin D supplementation, and a low-fat dietary pattern, the Women's Health Initiative (WHI) enrolled 161 808 postmenopausal US women (N = 68 132 in the clinical trials) aged 50 to 79 years at baseline from 1993 to 1998, and followed them up for up to 20 years...
May 1, 2024: JAMA
#2
JOURNAL ARTICLE
Stuart J Warden, Andrew Dick, Janet E Simon, Todd M Manini, David W Russ, Charalampos Lyssikatos, Leatha A Clark, Brian C Clark
Osteoporosis is characterized by low bone mass and structural deterioration of bone tissue, which leads to bone fragility (ie, weakness) and an increased risk for fracture. The current standard for assessing bone health and diagnosing osteoporosis is DXA, which quantifies areal BMD, typically at the hip and spine. However, DXA-derived BMD assesses only one component of bone health and is notably limited in evaluating the bone strength, a critical factor in fracture resistance. Although multifrequency vibration analysis can quickly and painlessly assay bone strength, there has been limited success in advancing a device of this nature...
January 2024: JBMR Plus
#3
JOURNAL ARTICLE
Almandouh H Bosilah, Mohamed Hussein, Mahmoud Abdelwahed Alboghdady, Ahmed Zaky, Ahmed Shafik Almorsy, Wael Soliman Taha, Mohammed Farouk Abd El Azeem, Amr Mohamed Sholkamy, Wael Abd Elatief Khafagy, Muhamed Ahmed Abdelmoaty, Ibrahim Mohamed Abo Eldahab, Bahaa Eldin Elmohamady Mohamed, Yasser Mohamed Said Diab, Ahmed Hashim Mohammed, Ahmed Samir Hamid Shaaban, Elsayed Mohammad Taha, Adel Aly Elboghdady, Sileem Ahmed Sileem, Hany Gaber Essawy, Elmetwally Farouk Elshahat, Ghada Ibrahim Elsaid Soror, Hamza Mohamed Abdelmohsen Mohamed
INTRODUCTION: The aim was to assess the hemostatic impact of B-Lynch sutures following an open myomectomy for efficacy. MATERIAL AND METHODS: In this prospective clinical research, performed in Alazhar university hospitals (Al-Hussain, Damietta, Assiut) and Minia University Maternity Hospital, 250 women scheduled for open myomectomy between January 2021 and January 2023 had multiple fibroid uteri with uterine sizes corresponding to 12-22 weeks. There were two groups of women...
March 2024: Menopause Review
#4
JOURNAL ARTICLE
Ainur Donayeva, Ainur Amanzholkyzy, Ibrahim A Abdelazim, Saule Rakhyzhanova, Akzhunus Mannapova, Talgar Abilov, Zaituna Khamidullina, Karlygash Bimagambetova, Gulnara Gubasheva, Dinara Kulzhanova, Akbayan Turesheva, Samat Saparbayev
INTRODUCTION: To detect the relationship between 25-hydroxy vitamin D (25(OH)D) and adolescents' parathyroid hormone (PTH) and bone mineral density (BMD). MATERIAL AND METHODS: Two hundred adolescent girls were recruited for this cross-sectional comparative study. After detailed evaluation, a pelvic sonography was performed for the studied adolescents to rule out any pelvic pathology. Adolescents' blood samples were collected to measure the thyroid stimulating hormone, prolactin, glycosylated haemoglobin (HbA1C ), PTH, and 25(OH)D...
March 2024: Menopause Review
#5
JOURNAL ARTICLE
Eva Tsoneva, Polina Dimitrova, Metodi Metodiev, Velizar Shivarov, Mariela Vasileva-Slaveva, Angel Yordanov, Stoyan Kostov
INTRODUCTION: Cervical cancer (CC) is a leading cause of mortality in women around the world, with the highest incidence rate still being in developing countries. The most common aetiological factor is infection with high-risk human papilloma virus viral strains. Oxidative stress through generation of reactive oxygen species leads to lipid peroxidation and DNA damage. Studies show that reactive lipid electrophiles such as 4-hydroxynonenal (4-HNE) produced in the process play an important role in cancer signalling pathways and are a good biomarker for oxidative stress...
March 2024: Menopause Review
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JOURNAL ARTICLE
Monika Szafarowska, Marcin Rosiński, Agnieszka Segiet-Święcicka, Szymon Jędrzejczyk, Michał Jerzak, Małgorzata Jerzak
INTRODUCTION: Polycystic ovary syndrome (PCOS) is a complex hormonal condition associated with psychological, reproductive, and metabolic features. Low-grade inflammation is a recognised factor causing metabolic and reproductive disorders in PCOS, which is why anti-inflammation approaches in PCOS treatment, especially during the COVID pandemic, are considered. A promising therapeutic option is osteopathic manipulative treatment (OMT), which activates the cholinergic anti-inflammatory pathway and can inhibit proinflammatory cytokines, such as TNF, IL-1β, and TNF-β...
March 2024: Menopause Review
#7
JOURNAL ARTICLE
Elham Nejadsadeghi, Elham Eshaghi Gorji, Ahmad Vakili-Basir, Samaneh Norouzi, Seyedeh Leila Dehghani, Shahab Papi
INTRODUCTION: Urinary tract infection (UTI) is a prevalent infection among the elderly population, often culminating in more severe and life-threatening complications. The prevalence of diabetes among elderly individuals is markedly on the rise, with UTI emerging as the most prevalent infectious ailment in this diabetic cohort. This study aims to ascertain the influence of theory-based education on promoting UTI prevention behaviours among elderly diabetic women. MATERIAL AND METHODS: In this experimental study, 100 elderly women with diabetes who sought care at comprehensive health service centres in Miandoab City between January and May 2022 were assessed...
March 2024: Menopause Review
#8
REVIEW
Ipsita Mohapatra, Subha Ranjan Samantaray
Hysterectomy is a common surgical procedure performed to remove the uterus. This is considered as a clean-contaminated surgical procedure. It is a safe procedure, but major and minor complications can occur, including vault hematoma and vault cellulitis, which are specific to the surgical site. Vault hematoma is the accumulation of blood within the vaginal vault, while vault cellulitis is an infection of the vaginal vault or the surgical cuff following a hysterectomy. Vault hematoma may be caused by trauma during surgery, improper hemostasis or infection...
March 2024: Menopause Review
#9
JOURNAL ARTICLE
Soner Gök, Ayhan Atigan, Berfin Can Gök
INTRODUCTION: The aim of the present study was to investigate the association between some risk factors and endometrial pathologies determined by transvaginal sonography (TVS), as well as the diagnostic predictive values of serum oestradiol (E2) levels, subcutaneous adipose tissue (SAT) thickness, endometrium thickness (ET), and the ratio of ET to uterine wall full thickness (UWT) in differential diagnosis of malignant, precancerous, and benign pathologies of endometrium in patients with postmenopausal bleeding (PMB) or with asymptomatic increased endometrial thickness...
March 2024: Menopause Review
#10
JOURNAL ARTICLE
Vasil Nanev, Hristo Milev, Desislava Dimitrova, Silvia Naneva, Strahil Asenov Strashilov, Angel Yordanov, Miroslava Mihailova, Simoneta Ivanova, Milena Karcheva, Ivan Ivanov
INTRODUCTION: Breast carcinoma is a heterogeneous disease, characterised by diverse clinical behaviour. The aim of this study was to assess how cleaved caspase-3 and Ki-67 index, evaluated on diagnostic biopsy, are related to response to neoadjuvant chemotherapy in the context of molecular subtype, post-treatment tumour, N category, and grade. MATERIAL AND METHODS: A retrospective analysis was carried out among 110 breast cancer patients. Ki-67 levels and caspase-3 expression on diagnostic biopsy were explored regarding their relation to tumour grade and molecular subtype, ypT, ypN categories, and T and N categories according to Sataloff tumour response evaluation...
March 2024: Menopause Review
#11
Shagun, Alex Kim, Victoria Koshevarova, Payam Mohammadinejad, Micah Murphy, Peeyush Bhargava
This case report follows a 66-year-old female who originally presented with malignant melanoma in the left knee and recurrence in the left inguinal region. This prompted a whole body FDG PET/CT scan which showed incidental focal hypermetabolism in the uterus. The diagnosis of endometrial cancer was confirmed at biopsy, and the patient was treated with total abdominal hysterectomy. Melanoma patients are at increased risk of second primary malignancy, and endometrial cancer is a common second primary often diagnosed in cancer survivors...
July 2024: Radiology Case Reports
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JOURNAL ARTICLE
Anna Onisiforou, Christiana C Christodoulou, Eleni Zamba-Papanicolaou, Panos Zanos, Polymnia Georgiou
BACKGROUND: The hippocampus, vital for memory and learning, is among the first brain regions affected in Alzheimer's Disease (AD) and exhibits adult neurogenesis. Women face twice the risk of developing AD compare to men, making it crucial to understand sex differences in hippocampal function for comprehending AD susceptibility. METHODS: We conducted a comprehensive analysis of bulk mRNA postmortem samples from the whole hippocampus (GSE48350, GSE5281) and its CA1 and CA3 subfields (GSE29378)...
2024: Frontiers in Endocrinology
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JOURNAL ARTICLE
Amy L Inselman, Elysia A Masters, Jalina N Moore, Rajiv Agarwal, Audrey Gassman, Gemma Kuijpers, Richard D Beger, Kenneth B Delclos, Sybil Swift, Luísa Camacho, Michelle M Vanlandingham, Daniel Sloper, Noriko Nakamura, Gonçalo Gamboa da Costa, Kellie Woodling, Matthew Bryant, Raul Trbojevich, Qiangen Wu, Florence McLellen, Donna Christner
Preparations of black cohosh extract are sold as dietary supplements marketed to relieve the vasomotor symptoms of menopause, and some studies suggest it may protect against postmenopausal bone loss. Postmenopausal women are also frequently prescribed bisphosphonates, such as risedronate, to prevent osteoporotic bone loss. However, the pharmacodynamic interactions between these compounds when taken together is not known. To investigate possible interactions, 6-month-old, female Sprague-Dawley rats underwent bilateral ovariectomy or sham surgery and were treated for 24 weeks with either vehicle, ethinyl estradiol, risedronate, black cohosh extract or coadministration of risedronate and black cohosh extract, at low or high doses...
2024: Frontiers in Pharmacology
#14
JOURNAL ARTICLE
Christos Markopoulos, Nikolaos Tsoulos, Konstantinos Agiannitopoulos, Evangelia Karagianni
BACKGROUND/AIM: Breast cancer remains the most prevalent type of cancer among women worldwide, and it remains the primary cause of cancer-related deaths in this demographic. Neuroendocrine breast cancer (NBC), an uncommon subtype comprising less than 1% of cases, typically occurs in older women and displays as a slow-growing, low-grade condition. NBC exhibits distinct histological patterns and immunohistochemical markers. Given the limited data on NBC, assays are required that will provide information on molecular profiling and assist in clinical decision making...
2024: In Vivo
#15
JOURNAL ARTICLE
Luana Ferreira Campos, Guilherme de Andrade Costa, Marina Domingues Feitosa, Iuri Ferreira Félix, Ligia Gabrielli, Maria da Conceição C Almeida, Estela Ml Aquino, Roque Aras Júnior
IMPORTANCE: Menopausal hormone therapy (HT) includes a wide variety of hormonal compounds, and its effect on blood pressure is still uncertain. OBJECTIVE: The aim of this study was to assess evidence regarding the effect of HT on blood pressure in postmenopausal women and its association with arterial hypertension. EVIDENCE REVIEW: This systematic review and meta-analysis included randomized clinical trials and prospective observational studies...
April 30, 2024: Menopause: the Journal of the North American Menopause Society
#16
JOURNAL ARTICLE
Suzanne T Witt, Alana Brown, Laura Gravelsins, Maria Engström, Elisabet Classon, Nina Lykke, Elisabeth Åvall-Lundqvist, Elvar Theordorsson, Jan Ernerudh, Preben Kjölhede, Gillian Einstein
OBJECTIVE: Ovarian removal prior to spontaneous/natural menopause (SM) is associated with increased risk of late life dementias including Alzheimer's disease. This increased risk may be related to the sudden and early loss of endogenous estradiol. Women with breast cancer gene mutations (BRCAm) are counseled to undergo oophorectomy prior to SM to significantly reduce their risk of developing breast, ovarian, and cervical cancers. There is limited evidence of the neurological effects of ovarian removal prior to the age of SM showing women without the BRCAm had cortical thinning in medial temporal lobe structures...
April 30, 2024: Menopause: the Journal of the North American Menopause Society
#17
JOURNAL ARTICLE
Jasmin Mahabamunuge, Siwen Wang, Sheryl L Rifas-Shiman, Sabrina Faleschini, Victoria W Fitz, Jan Shifren, Jorge E Chavarro, Emily Oken, Marie-France Hivert
OBJECTIVE: The aim of this study was to examine associations of anti-Müllerian hormone (AMH) levels in gravid women in their mid-30s with menopausal symptoms ~14 years later and age at natural menopause. METHODS: In this prospective analysis, 474 participants in Project Viva, a longitudinal cohort, were enrolled during pregnancy between 1999 and 2002. AMH levels were determined using plasma samples collected 3 years postpartum. Participants completed the Menopause Rating Scale (MRS) and self-reported age at and reason for menopause at the 17 years postpartum visit (Mid-Life Visit)...
April 30, 2024: Menopause: the Journal of the North American Menopause Society
#18
JOURNAL ARTICLE
Sarah Lensen, Vincent S Paramanandam, Michaela Gabes, Gesina Kann, Theresa Donhauser, Niamh F Waters, Anna D Li, Michelle Peate, Nipuni S Susanto, Lucy E Caughey, Fatema Rangoonwal, Jingbo Liu, Patrick Condron, Panagiotis Anagnostis, David F Archer, Nancy E Avis, Robin J Bell, Janet S Carpenter, Peter Chedraui, Monica Christmas, Melanie Davies, Tim Hillard, Myra S Hunter, Stamatina Iliodromiti, Nicole G Jaff, Unnop Jaisamrarn, Hadine Joffe, Sunila Khandelwal, Ludwig Kiesel, Pauline M Maki, Gita D Mishra, Rossella E Nappi, Nick Panay, Amos Pines, Helen Roberts, Serge Rozenberg, Camilo Rueda, Jan Shifren, James A Simon, Paul Simpson, Muhammad Fidel Ganis Siregar, Petra Stute, Joan Tan Garcia, Amanda J Vincent, Wendy Wolfman, Martha Hickey
OBJECTIVE: The aim of the study is to identify suitable definitions and patient-reported outcome measures (PROMs) to assess each of the six core outcomes previously identified through the COMMA (Core Outcomes in Menopause) global consensus process relating to vasomotor symptoms: frequency, severity, distress/bother/interference, impact on sleep, satisfaction with treatment, and side effects. METHODS: A systematic review was conducted to identify relevant definitions for the outcome of side-effects and PROMs with acceptable measurement properties for the remaining five core outcomes...
April 30, 2024: Menopause: the Journal of the North American Menopause Society
#19
JOURNAL ARTICLE
María S Vallejo, Juan E Blümel, Peter Chedraui, Konstantinos Tserotas, Carlos Salinas, Marcio A Rodrigues, Doris A Rodríguez, Claudia Rey, Eliana Ojeda, Mónica Ñañez, Álvaro Monterrosa-Castro, Gustavo Gómez-Tabares, María T Espinoza, Carlos Escalante, Alejandra Elizalde, Maribel Dextre, Andrés Calle, Sócrates Aedo
OBJECTIVE: Musculoskeletal disorders frequently affect postmenopausal women. This study aims to compare muscle disorders between women according to the type of experienced menopause: premature (PM) or normal age of menopause (NAM). METHODS: This was a cross-sectional study conducted in nine Latin American countries in which late postmenopausal women (55 to 70 years) were surveyed with a general questionnaire, the Menopause Rating Scale (MRS: item #4 exploring musculoskeletal discomfort), and the trength, assistance with walking, rising from a chair, climbing stairs, and falling questionnaire (risk of sarcopenia)...
April 30, 2024: Menopause: the Journal of the North American Menopause Society
#20
JOURNAL ARTICLE
Guoqiao Zheng, Louise Baandrup, Jiangrong Wang, Rasmus Hertzum-Larsen, Charlotte Gerd Hannibal, Lina S Mørch, Mette Tuxen Faber, Karin Sundström, Susanne K Kjær
OBJECTIVE: Given that the evidence regarding the link between antidepressant use and ovarian cancer risk is equivocal, we investigated this research question by conducting two nationwide nested case-control studies among the Danish and Swedish populations. METHODS: Altogether, 14,121 women with epithelial ovarian cancer (30-84 years old) (Denmark: 8976 diagnosed 2000-2019, Sweden: 5145 diagnosed 2010-2018) were randomly age-matched with 564,840 female controls (359,040 from Denmark, and 205,800 from Sweden) using risk set sampling...
April 25, 2024: Maturitas
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