Karen G C B Bindels-de Heus, Doesjka A Hagenaar, Ilonka Dekker, Danielle C M van der Kaay, Gerthe F Kerkhof, Encore Expertise Center For As, Ype Elgersma, Marie-Claire Y de Wit, Sabine E Mous, Henriette A Moll
Angelman Syndrome (AS) is a rare genetic disorder caused by lack of maternal UBE3A protein due to a deletion of the chromosome 15q11.2-q13 region, uniparental paternal disomy, imprinting center defect, or pathogenic variant in the UBE3A gene. Characteristics are developmental delay, epilepsy, behavioral, and sleep problems. There is some evidence for hyperphagia, shorter stature, and higher BMI compared to neurotypical children, but longitudinal studies on growth are lacking. In this study, we analyzed prospectively collected data of 145 children with AS, who visited the ENCORE Expertise Center between 2010 and 2021, with a total of 853 visits...
September 15, 2023: Journal of Clinical Medicine