Javier Donate-Correa, Ernesto Martín-Núñez, Carolina Hernández-Carballo, Ainhoa González-Luis, Carmen Mora-Fernández, Alberto Martín-Olivera, Sergio Rodríguez-Ramos, Purificación Cerro-López, Ángel López-Castillo, Alejandro Delgado-Molinos, Victoria Castro López-Tarruella, Juan F Navarro-González
Fibroblast growth factor 23 (FGF23) levels are often elevated in chronic kidney disease (CKD). FGF23 and inflammation are common characteristics in CKD, and both are associated with worse disease progression and the occurrence of complications. The existence of an interaction between FGF23 and inflammation has been suggested, each of which influences the expression and activity of the other, leading to a vicious feedback loop with adverse outcomes, including cardiovascular disease and mortality. In this work, we determined circulating FGF23 levels in a group of patients with CKD stages 3 and 4 subjected to elective femoral endarterectomy due to established peripheral artery disease (PAD), a condition resulting from an athero-inflammatory process, and we studied its associations with different inflammatory markers and mediators...
May 17, 2024: International Journal of Molecular Sciences