Sofi Imtiyaz Ali, Ahmed M E Elkhalifa, Showkat Ul Nabi, Faisal Sualeh Hayyat, Mehak Nazar, Syed Taifa, Rabia Rakhshan, Iqra Hussain Shah, Muzaffer Shaheen, Imtiyaz Ahmad Wani, Umar Muzaffer, Ovais Shabir Shah, Dil Mohammad Makhdoomi, Elsadig Mohamed Ahmed, Khalil A A Khalil, Elsharif A Bazie, Khalid Ibrahim Zawbaee, Moataz Mohamed Al Hasan Ali, Rakan J Alanazi, Ibrahim Ali Al Bataj, Saeed Musfar Al Gahtani, Ali Jubran Salwi, Lina Saeed Alrodan
BACKGROUND: Peripheral insulin resistance and compromised insulin secretion from pancreatic β-cells are significant factors and pathogenic hallmarks of diabetes mellitus (DM). NF-κβ/TLR-4 and SERCA/Ca2+ pathways have been identified as potential pathways regulating insulin synthesis by preserving pancreatic β-cell functioning. The current study aimed to evaluate the therapeutic effect of aged garlic extract (AGE) against DM in a streptozotocin (STZ)-induced rat model with particular emphasis on pancreatic β-cell functioning...
May 22, 2024: Diabetology & Metabolic Syndrome