Christian Stoppe, Bernard McDonald, Patrick Meybohm, Kenneth B Christopher, Stephen Fremes, Richard Whitlock, Siamak Mohammadi, Dimitri Kalavrouziotis, Gunnar Elke, Rolf Rossaint, Philipp Helmer, Kai Zacharowski, Ulf Günther, Matteo Parotto, Bernd Niemann, Andreas Böning, C David Mazer, Philip M Jones, Marion Ferner, Yoan Lamarche, Francois Lamontagne, Oliver J Liakopoulos, Matthew Cameron, Matthias Müller, Alexander Zarbock, Maria Wittmann, Andreas Goetzenich, Erich Kilger, Lutz Schomburg, Andrew G Day, Daren K Heyland
IMPORTANCE: Selenium contributes to antioxidative, anti-inflammatory, and immunomodulatory pathways, which may improve outcomes in patients at high risk of organ dysfunctions after cardiac surgery. OBJECTIVE: To assess the ability of high-dose intravenous sodium selenite treatment to reduce postoperative organ dysfunction and mortality in cardiac surgery patients. DESIGN, SETTING, AND PARTICIPANTS: This multicenter, randomized, double-blind, placebo-controlled trial took place at 23 sites in Germany and Canada from January 2015 to January 2021...
March 1, 2023: JAMA Surgery