Yuetian Liu, Lijuan Du, Hua Zhang, Guanrong Li, Yang Luo, Zeming Hu, Rong Xu, Jie Yao, Zheyuan Shi, Yige Chen, Chi Zhang, Zhanping Jin, Caihua Zhang, Chanchan Xie, Jun Fu, Yabin Zhu, Yingchun Zhu
Articular cartilage tissue has limited self-repair capabilities, with damage frequently progressing to irreversible degeneration. Engineered tissues constructed through bioprinting and embedded with stem cell aggregates offer promising therapeutic alternatives. Aggregates of bone marrow mesenchymal stromal cells (BMSCs) demonstrate enhanced and more rapid chondrogenic differentiation than isolated cells, thus facilitating cartilage repair. However, it remains a key challenge to precisely control biochemical microenvironments to regulate cellular adhesion and cohesion within bioprinted matrices simultaneously...
May 3, 2024: Journal of Materials Chemistry. B, Materials for Biology and Medicine