Qianli Jia, Yiming Duan, Yaoyao Liu, Juntao Liu, Jinping Luo, Yilin Song, Zhaojie Xu, Kui Zhang, Jin Shan, Fan Mo, Mixia Wang, Ying Wang, Xinxia Cai
Precise assessment of wakefulness states during sevoflurane anesthesia and timely arousal are of paramount importance to refine the control of anesthesia. To tackle this issue, a bidirectional implantable microelectrode array (MEA) is designed with the capability to detect electrophysiological signal and perform in situ deep brain stimulation (DBS) within the dorsomedial hypothalamus (DMH) of mice. The MEA, modified with platinum nanoparticles/IrOx nanocomposites, exhibits exceptional characteristics, featuring low impedance, minimal phase delay, substantial charge storage capacity, high double-layer capacitance, and longer in vivo lifetime, thereby enhancing the sensitivity of spike firing detection and electrical stimulation (ES) effectiveness...
May 23, 2024: ACS Sensors