Han-Xiao Chen, Xin-Yu Wang, Biao Yu, Chuan-Lin Feng, Guo-Feng Cheng, Lei Zhang, Jun-Jun Wang, Ying Wang, Ruo-Wen Guo, Xin-Miao Ji, Wen-Jing Xie, Wei-Li Chen, Chao Song, Xin Zhang
Acetaminophen (APAP), the most frequently used mild analgesic and antipyretic drug worldwide, is implicated in causing 46% of all acute liver failures in the USA and between 40% and 70% in Europe. The predominant pharmacological intervention approved for mitigating such overdose is the antioxidant N-acetylcysteine (NAC); however, its efficacy is limited in cases of advanced liver injury or when administered at a late stage. In the current study, we discovered that treatment with a moderate intensity static magnetic field (SMF) notably reduced the mortality rate in mice subjected to high-dose APAP from 40% to 0%, proving effective at both the initial liver injury stage and the subsequent recovery stage...
May 18, 2024: Zoological Research