Antje Schmidt-Pogoda, Johannes Kaesmacher, Nadine Bonberg, Nils Werring, Jan-Kolja Strecker, Mailin Hannah Marie Koecke, Carolin Beuker, Jan Gralla, Raphael Meier, Heinz Wiendl, Heike Minnerup, Urs Fischer, Jens Minnerup
BACKGROUND: The "translational roadblock" between successful animal stroke studies and neutral clinical trials is usually attributed to conceptual weaknesses. However, we hypothesized that rodent studies cannot inform the human disease due to intrinsic pathophysiological differences between rodents and humans., i.e., differences in infarct evolution. METHODS: To verify our hypothesis, we employed a mixed study design and compared findings from meta-analyses of animal studies and a retrospective clinical cohort study...
2024: Frontiers in Neurology