Disha P Vala, Amy Dunne Miller, Aditi Atmasidha, Mehul P Parmar, Chirag D Patel, Dipti B Upadhyay, Savan S Bhalodiya, Aday González-Bakker, Adam N Khan, Joaquina Nogales, José M Padrón, Sourav Banerjee, Hitendra M Patel
There is a continuous and pressing need to establish new brain-penetrant bioactive compounds with anti-cancer properties. To this end, a new series of 4'-((4-substituted-4,5-dihydro-1H-1,2,3-triazol-1-yl)methyl)-[1,1'-biphenyl]-2-carbonitrile (OTBN-1,2,3-triazole) derivatives were synthesized by click chemistry. The series of bioactive compounds were designed and synthesized from diverse alkynes and N3 -OTBN, using copper (II) acetate monohydrate in aqueous dimethylformamide at room temperature. Besides being highly cost-effective and significantly reducing synthesis, the reaction yielded 91-98 % of the target products without the need of any additional steps or chromatographic techniques...
May 25, 2024: Bioorganic Chemistry