Maria Assunta Costa, Maria Rosalia Mangione, Radha Santonocito, Rosa Passantino, Daniela Giacomazza, Fabio Librizzi, Oscar Moran, Rita Carrotta
Liposomes are shell nanoparticles able to embed hydrophobic molecules into their lipid layers to be released to cells. In pharmaceutical sciences, liposomes remain the delivery system with the highest biocompatibility, stability, loading characteristics, tunable physicochemical properties. Squalene is a natural, water insoluble, lipid, abundant in olive oil and shark liver. Studies in vitro and in animal models suggest protective and inhibitory effects of squalene against cancer. To study its effect on cells, and to overcome its insolubility in water, we have designed and produced large unilamellar liposomes containing different quantities of this terpene (0%, 2...
October 1, 2018: Colloids and Surfaces. B, Biointerfaces