Fabíola Iagher, Sérgio Ricardo de Brito Belo, Katya Naliwaiko, Andressa Machado Franzói, Gleisson Alisson Pereira de Brito, Ricardo Key Yamazaki, Ana Lúcia Muritiba, Luis Alexandre Muehlmann, Jovani Antonio Steffani, Luiz Cláudio Fernandes
We investigated the effect of chronic supplementation with shark liver oil (SLO), an antitumor supplement source of n-3 fatty acids and 1-O-alkylglycerols, alone and combined with coconut fat (CF), a source of saturated fatty acids, on Walker 256 tumor growth and cachexia. Male rats were supplemented daily and orally with SLO and/or CF (1 g per kg body weight) for 7 wk. After 7 wk, 50% of animals were subcutaneously inoculated with 3 × 10(7) Walker 256 tumor cells. After 14 days, the rats were killed, the tumors were removed for lipid peroxidation measurement, and blood was collected for glycemia, triacylglycerolemia, and lacticidemia evaluation...
November 2011: Nutrition and Cancer