Rossella Alfano, Michelle Plusquin, Oliver Robinson, Sonia Brescianini, Lida Chatzi, Pekka Keski-Rahkonen, Evangelos Handakas, Lea Maitre, Tim Nawrot, Nivonirina Robinot, Theano Roumeliotaki, Franco Sassi, Augustin Scalbert, Martine Vrijheid, Paolo Vineis, Lorenzo Richiardi, Daniela Zugna
BACKGROUND: The mechanisms underlying childhood overweight and obesity are poorly known. Here, we investigated the direct and indirect effects of different prenatal exposures on offspring rapid postnatal growth and overweight in childhood, mediated through cord blood metabolites. Additionally, rapid postnatal growth was considered a potential mediator on childhood overweight, alone and sequentially to each metabolite. METHODS: Within four European birth-cohorts (N = 375 mother-child dyads), information on seven prenatal exposures (maternal education, pre-pregnancy BMI, weight gain and tobacco smoke during pregnancy, age at delivery, parity, and child gestational age), selected as obesogenic according to a-priori knowledge, was collected...
July 2022: International Journal of Obesity