Luc Malaval, Hélène Follet, Delphine Farlay, Evelyne Gineyts, Sebastien Rizzo, Charlene Thomas, Mathieu Maalouf, Myriam Normand, Brigitte Burt-Pichat, Wafa Bouleftour, Arnaud Vanden-Boscche, Norbert Laroche, Laurence Vico
Osteopontin (OPN) and Bone Sialoprotein (BSP), abundantly expressed by osteoblasts and osteoclasts, appear to have important, partly overlapping functions in bone. In gene-knockout (KO, -/-) models of either protein and their double (D)KO in the same CD1/129sv genetic background, we analyzed the morphology, matrix characteristics, and biomechanical properties of femur bone in 2 and 4 month old, male and female mice. OPN-/- mice display inconsistent, perhaps localized hypermineralization, while the BSP-/- are hypomineralized throughout ages and sexes, and the low mineralization of young DKO mice recovers with age...
May 11, 2024: Calcified Tissue International