Alessandra Fanciulli, Iva Stankovic, Omer Avraham, Milica Jecmenica Lukic, Adi Ezra, Fabian Leys, Georg Goebel, Florian Krismer, Igor Petrovic, Marina Svetel, Klaus Seppi, Vladimir Kostic, Nir Giladi, Werner Poewe, Gregor K Wenning, Tanya Gurevich
BACKGROUND: A 4-item score based on ≥2 features out of orthostatic hypotension, overactive bladder, urinary retention and postural instability was previously shown to early distinguish the Parkinson-variant of multiple system atrophy (MSA-P) from Parkinson's disease (PD) with 78% sensitivity and 86% specificity. OBJECTIVES: To replicate and improve the 4-item MSA-P score. METHODS: We retrospectively studied 161 patients with early parkinsonism [ie, ≤2 years disease duration or no postural instability, aged 64 (57; 68) years, 44% females] and a diagnosis of clinically established MSA-P (n = 38) or PD (n = 123) after ≥24 months follow-up...
April 24, 2024: Movement Disorders Clinical Practice