Theresa Wimberley, Isabell Brikell, Aske Astrup, Janne T Larsen, Liselotte V Petersen, Clara Albiñana, Bjarni J Vilhjálmsson, Cynthia M Bulik, Zheng Chang, Giuseppe Fanelli, Janita Bralten, Nina R Mota, Jordi Salas-Salvadó, Fernando Fernandez-Aranda, Monica Bulló, Barbara Franke, Anders Børglum, Preben B Mortensen, Henriette T Horsdal, Søren Dalsgaard
BACKGROUND: Psychiatric disorders and type 2 diabetes mellitus (T2DM) are heritable, polygenic, and often comorbid conditions, yet knowledge about their potential shared familial risk is lacking. We used family designs and T2DM polygenic risk score (T2DM-PRS) to investigate the genetic associations between psychiatric disorders and T2DM. METHODS: We linked 659 906 individuals born in Denmark 1990-2000 to their parents, grandparents, and aunts/uncles using population-based registers...
May 27, 2024: Psychological Medicine