Brooke Szczesny, Meher Preethi Boorgula, Sameer Chavan, Monica Campbell, Randi K Johnson, Kai Kammers, Emma E Thompson, Madison S Cox, Gautam Shankar, Corey Cox, Andréanne Morin, Wendy Lorizio, Michelle Daya, Samir N P Kelada, Terri H Beaty, Ayo P Doumatey, Alvaro A Cruz, Harold Watson, Edward T Naureckas, B Louise Giles, Ganiyu A Arinola, Olumide Sogaolu, Adegoke G Falade, Nadia N Hansel, Ivana V Yang, Christopher O Olopade, Charles N Rotimi, R Clive Landis, Camila A Figueiredo, Matthew C Altman, Eimear Kenny, Ingo Ruczinski, Andrew H Liu, Carole Ober, Margaret A Taub, Kathleen C Barnes, Rasika A Mathias
Asthma has striking disparities across ancestral groups, but the molecular underpinning of these differences is poorly understood and minimally studied. A goal of the Consortium on Asthma among African-ancestry Populations in the Americas (CAAPA) is to understand multi-omic signatures of asthma focusing on populations of African ancestry. RNASeq and DNA methylation data are generated from nasal epithelium including cases (current asthma, N = 253) and controls (never-asthma, N = 283) from 7 different geographic sites to identify differentially expressed genes (DEGs) and gene networks...
May 28, 2024: Nature Communications