Nondumiso Premilla Dube, Vuyelwa Jacqueline Tembu, Getrude R Nyemba, Candace Davison, Goitsemodimo Herckious Rakodi, Douglas Kemboi, Jo-Anne de la Mare, Xavier Siwe-Noundou, Amanda-Lee Ezra Manicum
BACKGROUND: Stigmasterol is an unsaturated phytosterol that belong to the class of tetracyclic steroids abundant in Rhoicissus tridentata. Stigmasterol is an important constituent since it has shown impressive pharmacological effects such as anti-osteoarthritis, anticancer, anti-diabetic, anti-inflammatory, antiparasitic, immunomodulatory, antifungal, antioxidant, antibacterial, and neuroprotective activities. Furthermore, due to the presence of π system and hydroxyl group, stigmasterol is readily derivatized through substitution and addition reactions, allowing for the synthesis of a wide variety of stigmasterol derivatives...
September 11, 2023: BMC complementary medicine and therapies