cga | Page 2

A Branagan, L Perrem, J Semberova, A O'Sullivan, J Miletin, A Doolan
BACKGROUND: Early discontinuation of total parenteral nutrition (TPN) at 100 ml/kg/day of enteral feeds, compared with 140 ml/kg/day, led to significant delay in time to regain the birth weight in very low birth weight infants (birth weight < 1500 g, VLBW). Our aim was to compare the growth of infants in relation with timing of TPN discontinuation up to 2 years corrected gestational age (CGA). METHODS: Posttrial follow-up study using review of paper medical records...
May 5, 2020: European Journal of Clinical Nutrition
Katharina V Schulze, Neil A Hanchard, Michael F Wangler
PURPOSE: The persistence of hypermutable CGN (CGG, CGA, CGC, CGU) arginine codons at high frequency suggests the possibility of negative selective pressure at these sites and that arginine codon usage could be a predictive indicator of human disease genes. METHODS: We analyzed arginine codons (CGN, AGG, AGA) from all canonical Ensembl protein coding gene transcripts before comparing the frequency of CGN codons between genes with and without human disease associations and with gnomAD constraint metrics...
May 6, 2020: Genetics in Medicine: Official Journal of the American College of Medical Genetics
Suey S Y Yeung, Esmee M Reijnierse, Marijke C Trappenburg, Carel G M Meskers, Andrea B Maier
PURPOSE: Accurate estimation of the energy requirements including resting metabolic rate (RMR) is important for optimal nutritional care, yet its clinical determinants are unknown. This study examined the associations between clinical determinants of the Comprehensive Geriatric Assessment (CGA) domains with RMR among geriatric outpatients. MATERIALS & METHODS: Data were retrieved from cohorts of community-dwelling older adults (n = 84, 54 female) referring to geriatrics outpatient mobility clinics in both Amsterdam, The Netherlands and Melbourne, Australia...
April 23, 2020: Archives of Gerontology and Geriatrics
Ruifang Li, Jiarui Zhao, Liang Huang, Yanjie Yi, Aihua Li, Dandan Li, Mengke Tao, Youhao Liu
CGA-N12 is an antimicrobial peptide derived from the N-terminus of human chromogranin A and comprises the 65th to the 76th amino acids. Our previous studies showed that CGA-N12 reduces Candida tropicalis mitochondrial membrane potential. Here, we explored the mechanism that CGA-N12 collapsed the mitochondrial membrane potential by investigations of its action on the mitochondrial permeability transition pore (mPTP) complex of C. tropicalis. The results showed that CGA-N12 induced Cyt c leakage, mitochondria swelling and led to PEG of molecular weight 1000 Da penetrate mitochondria...
May 5, 2020: Bioscience Reports
Anza-Tshilidzi Ramabulana, Paul Steenkamp, Ntakadzeni Madala, Ian A Dubery
Bidens pilosa is an edible herb from the Asteraceae family which is traditionally consumed as a leafy vegetable. B. pilosa has many bioactivities owing to its diverse phytochemicals, which include aliphatics, terpenoids, tannins, alkaloids, hydroxycinnamic acid (HCA) derivatives and other phenylpropanoids. The later include compounds such as chlorogenic acids (CGAs), which are produced as either regio - or geometrical isomers. To profile the CGA composition of B. pilosa , methanol extracts from tissues, callus and cell suspensions were utilized for liquid chromatography coupled to mass spectrometric detection (UHPLC-QTOF-MS/MS)...
April 29, 2020: Metabolites
Jens F Rehfeld, Kasper Broedbaek, Jens P Goetze, Ulrich Knigge, Linda M Hilsted
Objective : The incidence of enteropancreatic neuroendocrine tumours (NET) is increasing. Chromogranin A (CgA) in plasma is a marker in patients suspected of NET tumours. CgA, however, is a precursor protein subjected to cellular processing that challenges quantitation and hence the use of CgA in diagnostics. Materials and methods : CgA concentrations in plasma sampled from 130 well-characterized patients with small intestinal NETs and from 30 healthy subjects were measured with eight commercial CgA kits, an in-house radioimmunoassay (RIA) and a processing-independent assay (PIA)...
April 30, 2020: Scandinavian Journal of Gastroenterology
Lu Dang, Guanglei Li, Xinjie Wang, Shisheng Huang, Yu Zhang, Yuanxin Miao, Lisi Zeng, Shuzhong Cui, Xingxu Huang
OBJECTIVES: Recently developed CRISPR-dependent cytosine base editor (CBE), converting four codons (CAA, CAG, CGA and TGG) into stop codons without DNA double-strand breaks (DSB), serves as an efficient gene disruption strategy besides uncontrollable CRISPR-mediated frameshift. However, the detailed difference of gene knockout between the two systems has not been clarified. MATERIALS AND METHODS: Here, we selected some sgRNAs with different position background, then HEK293T cells were transfected with CBE/Cas9 plasmids together with sgRNAs...
April 29, 2020: Cell Proliferation
Magnus Nord, Carl Johan Östgren, Jan Marcusson, Maria Johansson
Objective: Comprehensive geriatric assessment (CGA) is recommended for the management of frailty. Little is known about professionals' experiences of CGA; therefore we wanted to investigate the experiences of staff in primary care using a new CGA tool: the Primary care Assessment Tool for Elderly (PASTEL). Design: Focus group interviews. Manifest qualitative content analysis. Setting: Nine primary health care centres in Sweden that participated in a CGA intervention. These centres represent urban as well as rural areas...
April 29, 2020: Scandinavian Journal of Primary Health Care
Ruifang Li, Weini Shi, Ruiling Zhang, Liang Huang, Yanjie Yi, Aihua Li, Hongjuan Jing, Mengke Tao, Meng Zhang, Nanqi Pei
The antimicrobial peptide CGA-N12 (NH2-ALQGAKERAHQQ-COOH) is an active peptide derived from chromogranin A (CGA) and consists of the 65th to 76th amino acids of the N-terminus. The results of our previous studies showed that CGA-N12 exerts anti-Candida activity by inducing apoptosis without destroying the integrity of cell membranes. In this study, the effect of CGA-N12 on the cell membrane structure of Candida tropicalis was investigated. CGA-N12 resulted in the dissipation of the membrane potential, the increase in membrane fluidity, and the outflow of potassium ions in C...
April 29, 2020: Biochemical Journal
Zehra Yagmur Sahin Alak, Esra Ates Bulut, Ozge Dokuzlar, Idil Yavuz, Pinar Soysal, Ahmet Turan Isik
BACKGROUND & AIMS: Vitamin D deficiency is a public health problem. The resulting data showed that vitamin D is associated not only with calcium homeostasis, skeletal muscle health, but also with some chronic diseases. The aim of the study was to investigate long-term effects of vitamin D deficiency on gait-balance parameters in older adults. METHODS: 370 patients who applied to the geriatric outpatient clinic three times at six-months intervals and underwent comprehensive geriatric assessment (CGA), were retrospectively screened...
April 11, 2020: Clinical Nutrition
Anna Malczewska, Magdalena Witkowska, Monika Wójcik-Giertuga, Katarzyna Kuśnierz, Agnes Bocian, Agata Walter, Mateusz Rydel, Amanda Robek, Sylwia Pierzchała, Magdalena Malczewska, Izabela Leś-Zielińska, Damian Czyżewski, Dariusz Ziora, Joanna Pilch-Kowalczyk, Wojciech Zajecki, Beata Kos-Kudla
BACKGROUND: There is a substantial unmet clinical need for an accurate and effective blood biomarker for neuroendocrine neoplasms (NEN). We therefore evaluated, under real-world conditions, the clinical utility of the NETest as a liquid biopsy in an ENETS Centre of Excellence and compared its utility with chromogranin A (CgA). Methods Cohorts: Gastroenteropancreatic (GEP)-NEN (n=253), bronchopulmonary (BP)-NEN (n=64), thymic NEN (n=1), colon cancer (n=37), NSCLC (n=63), benign lung disease (n=59) and controls (n=86)...
April 24, 2020: Neuroendocrinology
Weiwei Sheng, Ermanno Malagola, Henrik Nienhüser, Zhengyu Zhang, Woosook Kim, Leah Zamechek, Antonia Sepulveda, Masahiro Hata, Yoku Hayakawa, Chun-Mei Zhao, Duan Chen, Timothy C Wang
BACKGROUND: Enterochromaffin-like (ECL) cells in the stomach express gastrin/CCK2 receptors and are known to expand under hypergastrinemia, but whether this results from expansion of existing ECL cells or increased production from progenitors has not been clarified. METHODS: We utilized mice with fluorescent reporter expression in ECL cells (Hdc-GFP) as well as Cck2r-CreERT2 and Hdc-CreERT2 mice combined with R26-tdTomato mice, and studied their expression and cell fate in the gastric corpus by using models of hypergastrinemia (gastrin infusion, omeprazole treatment)...
April 21, 2020: Cellular and Molecular Gastroenterology and Hepatology
David Vicente-Zurdo, Iván Romero-Sánchez, Noelia Rosales-Conrado, María Eugenia León-González, Yolanda Madrid
Extracellular accumulation of amyloid beta peptide (Aβ) is believed to be one of the main factors responsible for neurodegeneration in Alzheimer's disease (AD). Metals could induce Aβ aggregation, by their redox activity or binding properties to amyloid β fibrils, leading to their accumulation and deposition outside neurons. For this reason, metal chelation may have an acknowledged part to play in AD prevention and treatment. In the current work, the role of different selenium species, including selenium nanoparticles, in Aβ aggregation, was studied by evaluating their metal-chelating properties and their ability both to inhibit metal-induced Aβ1-42 aggregation fibrils and to disaggregate them once formed...
April 22, 2020: Analytical and Bioanalytical Chemistry
Siobhan Harding
Completing comprehensive geriatric assessments (CGA) for frail patients admitted to acute hospitals has well-established benefits and is advocated by national guidelines. There is high-quality evidence demonstrating an association between inpatient CGAs and the patient being alive and community-dwelling at 12-month follow-up. However, less well-known is the effectiveness of CGAs conducted within the emergency department (ED), with the primary purpose of facilitating admission avoidance, on reducing 30-day reattendance or readmission...
April 21, 2020: Age and Ageing
T Szarvas, A Csizmarik, T Fazekas, A Hüttl, P Nyirády, B Hadaschik, V Grünwald, L Püllen, Z Jurányi, Z S Kocsis, S F Shariat, S Sevcenco, A Maj-Hes, G Kramer
OBJECTIVES: To assess chromogranin A (CGA) and neuron-specific enolase (NSE) levels as well as their changes in different stages of prostatic adenocarcinomas (PCA). METHODS: Overall, 1095 serum samples of 395 patients divided in three treatment groups were analysed; the radical prostatectomy (RPE) cohort (n=157) included patients with clinically localized PCA, the docetaxel (DOC) and abiraterone (ABI)/enzalutamide (ENZA) cohort included 95 and 143 metastatic castration-resistant prostate cancer patients, respectively...
April 20, 2020: BJU International
C C Guo, X Y Zhang, Y X Wang, L Xie, C Q Chang
OBJECTIVE: To observe the effect of chlorogenic acid (chlorogenic acid, CGA) on the glucose tolerance and its curve characteristics in high fat diet-induced obesity (diet-induced-obesity, DIO) rats, so as to provide scientific grounds for the development and utilization of CGA in early prevention and reversal of prediabetes. METHODS: Eight of forty-six male Sprague-Dawley rats were randomly selected as the normal diet group (CON group), and the rest were fed with high-fat diet...
April 18, 2020: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
Gabriele Röhrig, Schmidt Pia, Michael Bussmann, Henning Kunter, Michael Johannes Noack, Anna Greta Barbe
BACKGROUND: Impaired oral health affects oral health-related quality of life (OHrQoL) in orthogeriatric hospitalized patients, and both might be associated with potential risk factors for functional impairment, based on the comprehensive geriatric assessment (CGA) and related blood laboratory values. As data on this field are scarce, we investigated possible associations between oral health, items of the geriatric oral health assessment instrument (GOHAI), CGA assessment tools, and relevant laboratory values...
March 13, 2020: European Geriatric Medicine
Da Hyun Ahn, Hea Eun Yang, Hyo Jung Kang, Kyung Hee Do, Seok Cheol Han, Soo Woong Jang, Jang Ho Lee
PURPOSE: To investigate characteristics of dysphagia in the oldest-old population and the effect of aging on swallowing physiology. METHODS: 418 (364 men, 54 women) patients who underwent videofluoroscopic swallow study (VFSS) for dysphagia were included. The patients were divided into an older group, group I (60-79 years old, n = 275) and the oldest-old group, group II (80-96 years old, n = 143). Sex, cognition, duration of symptoms, BMI (body mass index), frailty index derived from comprehensive geriatric assessment (FI-CGA), penetration aspiration scale (PAS), and videofluoroscopic dysphagia scale (VDS) scores and the etiologies of dysphagia were compared between the groups...
February 2020: European Geriatric Medicine
Katayoun Sepehri, McKenzie Sarah Braley, Betty Chinda, Macy Zou, Brandon Tang, Grace Park, Antonina Garm, Robert McDermid, Kenneth Rockwood, Xiaowei Song
Background: Frailty is characterized by loss of biological reserves and is associated with an increased risk of adverse health outcomes. Frailty can be operationalized using a Frailty Index (FI) based on the accumulation of health deficits; items under health evaluation in the well-established Comprehensive Geriatric Assessment (CGA) have been used to generate an FI-CGA. Traditionally, constructing the FI-CGA has relied on paper-based recording and manual data processing. As this can be time-consuming and error-prone, it limits widespread uptake of this proven type of frailty assessment...
2020: Frontiers in Public Health
Fiona Ohlendorf, Christoph Henkenberens, Thomas Brunkhorst, Tobias L Ross, Hans Christiansen, Frank M Bengel, Thorsten Derlin
BACKGROUND: A quantitative imaging biomarker is desirable to provide a comprehensive measure of whole-body tumor burden in patients with metastatic neuroendocrine tumors, and to standardize the evaluation of treatment-related changes. Therefore, we evaluated volumetric parameters for quantification of whole-body tumor burden from somatostatin receptor (SSR)- targeted PET/CT. METHODS: 32 patients with metastastic grade1/grade 2 gastroenteropancreatic neuroendocrine tumors who underwent a 68Ga-DOTA-TATE PET/CT for staging of disease before initiation of peptide receptor radionuclide therapy were included in this retrospective cohort analysis...
April 14, 2020: Quarterly Journal of Nuclear Medicine and Molecular Imaging
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