Nilanjana Majumder, Subhrajit Ganguly, Arijit Kumar Ghosh, Shreetoma Kundu, Antara Banerjee, Samiran Saha
AIMS: Visceral leishmaniasis (VL), caused by Leishmania donovani in India, is fatal if untreated, having serious concern of limited chemotherapeutic options. In this study, we evaluated anti-leishmanial efficacy of purified chlorogenic acid (CGA) against promastigotes and intracellular amastigotes infected into RAW264.7 macrophages. METHODS AND RESULTS: CGA was effective both on promastigotes (IC50 =78.394 µM i.e. 27.75 µg/mL) and intracellular amastigotes (ED50 =26...
April 5, 2020: Parasite Immunology
Marcos Daniel Saraiva, Amanda Lagreca Venys, Fábio Luiz Pantaleão Abdalla, Mariana Seabra Fernandes, Priscila Henriques Pisoli, Danilsa Margareth da Rocha Vilhena Sousa, Barbara Lobo Bianconi, Expedita Ângela Henrique, Vanessa Silva Suller Garcia, Lucas Henrique de Mendonça Maia, Gisele Sayuri Suzuki, Priscila Gonçalves Serrano, Marcel Hiratsuka, Claudia Szlejf, Wilson Jacob-Filho, Sérgio Márcio Pacheco Paschoal
BACKGROUND: The early identification of individuals at high risk for adverse outcomes by a Comprehensive Geriatric Assessment (CGA) in resource-limited primary care settings enables tailored treatments, however, the evidence concerning its benefits are still controversial. The main objective of this study was to examine the validity and reliability of the "Multidimensional Assessment of Older People in Primary Care (AMPI-AB)", a CGA for primary care in resource-limited settings...
March 30, 2020: BMC Geriatrics
Ophélie Carmon, Fanny Laguerre, Lina Riachy, Charlène Delestre-Delacour, Qili Wang, Emeline Tanguy, Lydie Jeandel, Dorthe Cartier, Tamou Thahouly, Anne-Marie Haeberlé, Laetitia Fouillen, Olivier Rezazgui, Damien Schapman, Alexandre Haefelé, Yannick Goumon, Ludovic Galas, Pierre-Yves Renard, Stéphane Alexandre, Nicolas Vitale, Youssef Anouar, Maité Montero-Hadjadje
Chromogranin A (CgA) is a key luminal actor of secretory granule biogenesis at the trans-Golgi network (TGN) level but the molecular mechanisms involved remain obscure. Here, we investigated the possibility that CgA acts synergistically with specific membrane lipids to trigger secretory granule formation. We show that CgA preferentially interacts with the anionic glycerophospholipid phosphatidic acid (PA). In accordance, bioinformatic analysis predicted a PA-binding domain (PABD) in CgA sequence that effectively bound PA (36:1) or PA (40:6) in membrane models...
March 29, 2020: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
Jing Luo, Chengfei Yang, Xing Luo, Yang Yang, Jia Li, Bo Song, Jiang Zhao, Longkun Li
AIMS: This study aimed to investigate the therapeutic effect and molecular mechanism of chlorogenic acid (CGA) on cyclophosphamide (CYP)-induced rat interstitial cystitis (IC). MATERIALS AND METHODS: An animal model of IC was established by intraperitoneal injection of CYP in female Sprague-Dawley rats. Eighty rats were randomly assigned to four groups: negative control (NC), NC treated with CGA (NC + CGA), IC, and IC treated with CGA (IC + CGA). Bladder urination function was assessed by analyzing urodynamic parameters...
March 24, 2020: Life Sciences
Yuxuan Sun, Yeshu Zhu, Chen Chen, Qunshan Zhu, Qianqian Zhu, Yanyue Zhou, Xiaojun Zhou, Peijun Zhu, Jun Li, Haijun Zhang
To determine the Dysgonia stuposa mitochondrial genome (mitogenome) structure and to clarify its phylogenetic position, the entire mitogenome of D. stuposa was sequenced and annotated. The D. stuposa mitogenome is 15,721 bp in size and contains 37 genes (protein-coding genes, transfer RNA genes, ribosomal RNA genes) usually found in lepidopteran mitogenomes. The newly sequenced mitogenome contained some common features reported in other Erebidae species, e.g., an A+T biased nucleotide composition and a non-canonical start codon for cox1 (CGA)...
2020: PeerJ
Cyprian Michalik, Kajetan Juszczak, Piotr Maciukiewicz, Tomasz Drewa, Jakub Kenig
The elderly constitute the group of patients who most often undergo elective urological procedures, and they are at the highest risk of poor surgical outcomes because of comorbidity and frailty. The current model of qualification for surgery is often subjective and based on tools which do not address the characteristics of the elderly. The Comprehensive Geriatric Assessment (CGA) and screening tools can help in the evaluation of older, particularly frail patients. The aim of the study was to review the literature on the usefulness of preoperative geriatric evaluation in patients undergoing urological treatment...
March 24, 2020: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
Enmin Ding, Huan Wang, Lei Han, Hengdong Zhang, Baoli Zhu
Noise-induced hearing loss (NIHL) is one of the most common occupational health risks in industrialized countries. It has been recognized to result from interactions between genetic and environmental factors. This study investigated the influence of genetic mutations in the potassium voltage-gated channel subfamily E regulatory subunit 1 (KCNE1) gene on susceptibility to NIHL. A total of 2689 industrial workers in eastern China were recruited to participate. Three single-nucleotide polymorphisms (SNPs) of KCNE1 were genotyped in noise-exposed workers who were classified into 589 cases and 639 control individuals...
March 23, 2020: Environmental Science and Pollution Research International
Zhu Han, Li He, Shuang Pan, Hui Liu, Xiaoli Hu
A novel and sensitive fluorescence analysis platform was constructed for the detection of chlorogenic acid (CGA) using carbon dots (C-dots) with prominent sensitivity and selectivity. Excitation-dependent emission fluorescence C-dots were fabricated using citric acid and l-histidine as precursors through an efficient one-step hydrothermal treatment. The maximum excitation and emission wavelength of the as-synthesized C-dots were 340 nm and 414 nm, respectively. Moreover, the as-prepared C-dots displayed excellent water solubility and good photostability...
March 23, 2020: Luminescence: the Journal of Biological and Chemical Luminescence
Yunlong Dong, Yongwen Li, Renwang Liu, Ying Li, Hongbing Zhang, Hongyu Liu, Jun Chen
A common method to distinguish large cell neuroendocrine carcinoma (LCNEC) from non-neuroendocrine large cell carcinoma (non-NE LCC) is from using specific immunohistochemistry markers, such as CgA, Syn, CD56 and Napsin A, however, the results remain controversial using these markers. Secretagogin (SCGN) is a newly discovered biomarker of neuroendocrine cells. In the present study, the expression of SCGN in 33 cases of human lung large cell carcinoma (LCC), including 17 cases of LCNEC and 16 cases of non-neuroendocrine (NE) LCC and lung cancer cell lines (A549, H1650, H358, H292 and H661)...
March 2020: Oncology Letters
Watcharaporn Taburee, Supinda Sirilak, Rossukon Khotcharrat, Prattana Anekpunyakul, Piyameth Dilokthornsakul, Nada Lukkahatai, Chitima Boongird
Purpose: The aims of this study were to explore prevalence of health-related problems and identify factors associated with health-related quality of life (HRQOL) among community-dwelling older adults (CDOAs) in rural Thailand. Methods: A total of 384 CDOAs with mean age of 71 years (SD = 7.6) were recruited. The Thai Ministry of Public Health's comprehensive geriatric assessment (CGA) was used to measure the CDOAs' health conditions in the primary care unit of community hospitals. HRQOL of the participants was assessed by using the EQ-5D questionnaire...
January 2020: Journal of Primary Care & Community Health
Chiara Giannotti, Andrea Massobrio, Daniela Cannata, Alessio Nencioni, Fiammetta Monacelli, Alessandra Aprile, Domenico Soriero, Stefano Scabini, Davide Pertile
BACKGROUND: As surgery remains the cornerstone of colorectal cancer (CRC) treatment, the number of older patients presented for colorectal resection is rapidly increasing. Nevertheless, the choice to operate an oldest-old patient still remain challenging and requires a careful assessment of risk to benefit ratio in order to guarantee appropriate surgical strategies and perioperative management. CASE PRESENTATION: A centenarian patient, acutely admitted to the emergency department, was diagnosed with an ileus caused by stenosing ascending colon cancer with abnormal distension of the right colon at high risk of perforation...
March 18, 2020: BMC Surgery
Hongli Wang, Yanqun Li, Sibo Wang, Dexin Kong, Sunil Kumar Sahu, Mei Bai, Haoyuan Li, Linzhou Li, Yan Xu, Hongping Liang, Huan Liu, Hong Wu
The Flos Lonicerae Japonicae (FLJ), Lonicera japonica Thunb, belonging to the Caprifoliaceae family, is an economically important plant that is highly utilized in traditional Chinese medicine as well as in Japanese medicine. The flowers of these plants are rich in chlorogenic acid (CGA) and luteoloside. Our previous study revealed that tetraploid L. japonica has higher fresh/dry weight, phenolic acids and flavonoids contents than those of diploid plants. However, why tetraploid L. japonica can yield higher CGA and luteolosides than that in diploid and what is the difference in the molecular regulatory mechanism of these pathways between diploid and tetraploids remained unclear...
2020: PeerJ
Aurore Goineau, Loïc Campion, Jean-Marie Commer, Brigitte Vié, Agnès Ghesquière, Guillaume Béra, Didier Jaffres, Nicolas Magné, Xavier Artignan, Jérôme Chamois, Philippe Bergerot, Gilles Créhange, Elisabeth Deniaud-Alexandre, Xavier Buthaud, Yazid Belkacémi, Mélanie Doré, Laure De Decker, Stéphane Supiot
Curative radiotherapy for prostate cancer is common in the elderly. However, concerns about potential toxicity have inhibited access to radiotherapy for this population, for whom preserving quality of life (QoL) is crucial. The primary endpoint was to identify predictors of impaired QoL in men aged 75 years or older treated with curative intent radiotherapy with or without androgen deprivation therapy (ADT) for localized prostate cancer. We prospectively performed comprehensive geriatric assessment (CGA) and administered QoL questionnaires to 208 elderly (>75 years) patients prior to, plus two and six months after, radiotherapy (NCT02876237)...
March 9, 2020: Cancers
Abhijit Dasgupta, Gautam K Bandyopadhyay, Indrani Ray, Keya Bandyopadhyay, Nirmalya Chowdhury, Rajat K De, Sushil K Mahata
Obesity is characterized by a state of chronic, unresolved inflammation in insulin-targeted tissues. Obesity-induced inflammation causes accumulation of proinflammatory macrophages in adipose tissue and liver. Proinflammatory cytokines released from tissue macrophages inhibits insulin sensitivity. Obesity also leads to inflammation-induced endoplasmic reticulum (ER) stress and insulin resistance. In this scenario, based on the data (specifically patterns) generated by our in vivo experiments on both diet-induced obese (DIO) and normal chow diet (NCD) mice, we developed an in silico state space model to integrate ER stress and insulin signaling pathways...
2020: Computational and Structural Biotechnology Journal
Alfonso J Cruz-Jentoft, Julia Daragjati, Laura Fratiglioni, Stefania Maggi, Arduino A Mangoni, Francesco Mattace-Raso, Marc Paccalin, Maria Cristina Polidori, Eva Topinkova, Luigi Ferrucci, Alberto Pilotto
MPI_AGE is a European Union co-funded research project aimed to use the Multidimensional Prognostic Index (MPI), a validated Comprehensive Geriatric Assessment (CGA)-based prognostic tool, to develop predictive rules that guide clinical and management decisions in older people in different European countries. A series of international studies performed in different settings have shown that the MPI is useful to predict mortality and risk of hospitalization in community-dwelling older subjects at population level...
March 16, 2020: Aging Clinical and Experimental Research
Tian-Ping Zhang, Hong-Miao Li, Rui Li, Qin Zhang, Yin-Guang Fan, Xiao-Mei Li, Hai-Feng Pan, Dong-Qing Ye
OBJECTIVE: An increasing number of studies have demonstrated the roles of adipokines in systemic lupus erythematosus (SLE). We aimed to investigate the association of genetic variations of omentin-1, adiponectin, and resistin with SLE susceptibility. METHODS: We selected 623 SLE patients and 665 normal controls in the present study. Genotyping of omentin-1 rs2274907, rs35779394, rs79209815, and rs13376023; adiponectin rs16861194 and rs266729; and resistin rs1862513, rs3745368, and rs3745367 was conducted by TaqMan SNP genotyping assays...
March 13, 2020: International Immunopharmacology
Marzena Matejczyk, Piotr Ofman, Katarzyna Dąbrowska, Renata Świsłocka, Włodzimierz Lewandowski
In the present work we compared the biological activity of DCF, 4'-OHDCF and 5-OHDCF as molecules of most biodegradation pathways of DCF and selected transformation products (2-hydroxyphenylacetic acid; 2,5-dihydroxyphenylacetic acid and 2,6-dichloroaniline) which are produced during AOPs, such as ozonation and UV/H2 O2 . We also examined the interaction of DCF with chlorogenic acid (CGA). CGA is commonly used in human diet and entering the environment along with waste mainly from the processing and brewing of coffee and it can be toxic for microorganisms included in activated sludge...
May 2020: Journal of Environmental Sciences (China)
Alberto Pilotto, Carlo Custodero, Stefania Maggi, Maria Cristina Polidori, Nicola Veronese, Luigi Ferrucci
Frailty is an important factor determining a higher risk of adverse health outcomes in older adults. Although scientific community in the last two decades put a lot of effort for its definition, to date no consensus was reached on its assessment. The mainstream thinking describes frailty as a loss of physical functions or as accumulation of multiple deficits. Recently, a novel conceptual model of frailty has emerged based on the loss of harmonic interaction between multiple domains (also referred as dimensions) including genetic, biological, functional, cognitive, psychological and socio-economic domain that ultimately lead to homeostatic instability...
March 11, 2020: Ageing Research Reviews
Alice Bonnefoy-Mazure, Geraldo De Coulon, Pierre Lascombes, Stéphane Armand
Purpose: Assessment of surgical treatments on gait in patients with bilateral cerebral palsy (CP) is often performed in short-term studies. The purpose of this study was to analyze the influence of single-event multilevel surgery (SEMLS) on long-term evolution of gait using gait deviation index (GDI) and walking speed. Methods: In all, 28 patients with bilateral CP (Gross Motor Function Classification System I to III) with two clinical gait analyses (CGA) were included (mean age: 9...
February 1, 2020: Journal of Children's Orthopaedics
Wenjin Xiao, Jinwei He, Wenzhen Fu, Youjia Xu, Zhenlin Zhang
INTRODUCTION: Collagen cross-linking, which is regulated by lysyl oxidase (LOX), plays critical roles in bone mechanical strength. LOX can influence bone remodeling by modulating osteoblast andosteoclastactivity. This study aimed to explore the effect of LOX gene polymorphisms on osteoporotic fractures susceptibility in postmenopausal Chinese women. METHODS: This was a prospective study of postmenopausal women who visited the outpatient and community clinics of the local Hospital...
March 9, 2020: Gene
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