Wen-Chi Chou, Hung Chang, Po-Nan Wang, Ming-Chung Kuo, Jin-Hou Wu, Tung-Liang Lin, Yi-Jiun Su, Hsiao-Wen Kao, Che-Wei Ou, Chia-Yen Hung, Shun-Wen Hsueh, Yu-Shin Hung
OBJECTIVES: Early mortality, defined as death within 120 days after initiated antitumor therapy, is an important issue especially for elder patients with B-cell lymphoma. This study aimed to evaluate the clinical value of comprehensive geriatric assessment (CGA) in early mortality prediction in elderly patients with B-cell lymphoma receiving immunochemotherapy. METHODS: Seventy-six consecutive patients with newly diagnosed B-cell lymphoma receiving immunochemotherapy from a medical center in Taiwan were prospectively enrolled...
May 30, 2020: European Journal of Haematology
Changwei Bi, Na Lu, Yiqing Xu, Chunpeng He, Zuhong Lu
The common bean ( Phaseolus vulgaris ) is a major source of protein and essential nutrients for humans. To explore the genetic diversity and phylogenetic relationships of P. vulgaris , its complete mitochondrial genome (mitogenome) was sequenced and assembled. The mitogenome is 395,516 bp in length, including 31 unique protein-coding genes (PCGs), 15 transfer RNA (tRNA) genes, and 3 ribosomal RNA (rRNA) genes. Among the 31 PCGs, four genes ( mttB , nad1 , nad4L , and rps10 ) use ACG as initiation codons, which are altered to standard initiation codons by RNA editing...
May 27, 2020: International Journal of Molecular Sciences
Merete Gregersen, Troels K Hansen, Bodil B Jørgensen, Else Marie Damsgaard
PURPOSE: Targeting health care interventions requires valid measurements when predicting unplanned hospital readmission. The Multidimensional Prognostic Index (MPI) based on Comprehensive Geriatric Assessment (CGA) enables the prediction of mortality and length of stay (LOS) in older hospitalized patients. Our aim was to validate if the MPI as a frailty tool could predict unplanned hospital readmission in geriatric patients. METHODS: This prognostic study was conducted in geriatric wards...
May 28, 2020: European Geriatric Medicine
Lis A Evered, Sarah Vitug, David A Scott, Brendan Silbert
BACKGROUND: Frailty is a reduced capacity to recover from a physiologically stressful event. It is well established that preoperative frailty is associated with poor postoperative outcomes, but it is unclear if this includes cognitive decline following anesthesia and surgery. This retrospective observational study was a secondary analysis of data from a previous study (the Anaesthesia, Cognition, Evaluation [ACE] study). We aimed to identify if preoperative frailty or prefrailty is associated with preoperative and postoperative neurocognitive disorders or postoperative cognitive dysfunction...
May 27, 2020: Anesthesia and Analgesia
Divya Verma, Myuran Kaneshamoorthy, Leila Bafadhel, Francesca Bonora, Rebecca Walker
No abstract text is available yet for this article.
February 2020: Future Healthcare Journal
José Alberto Domínguez-Alonso, David Conde-Estévez, David Bosch, Maria Pi-Figueras, Ignacio Tusquets
PURPOSE: Breast cancer is the most prevalent and lethal cancer among women. Forty-one percent of cases occur in people ≥ 70 years, hindering their treatment given its comorbidities and polypharmacy (PP). Potential drug-drug interactions (PDDI) were analyzed in elderly breast cancer patients between daily and oncospecific treatments and their associations with Age, BMI, Mini Nutritional Assessment (MNA), Frailty categorization, PP, and adverse effects. PATIENTS/METHODS: A cohort of 77 patients ≥ 70 years with breast cancer who underwent a Comprehensive Geriatric Assessment (CGA) were included...
May 24, 2020: Clinical & Translational Oncology
Nan Wang, Rui Kong, Wei Han, Jie Lu
BACKGROUND: Hepatoid adenocarcinoma of the stomach (HAS) has been recognized as a rare primary gastric tumor characterized by hepatocellular carcinoma-like histology. HAS often causes diagnostic confusion with conventional gastric adenocarcinoma (CGA) due to the difficulty to detect hepatoid differentiation solely based on findings from hematoxylin and eosin (H&E) staining. Hence, HAS should be distinguished from solid-type CGA based on their different biological behaviors. β-catenin is highly expressed in hepatocellular carcinoma (HCC), which is involved in the maintenance of tumor initiating cells, drug resistance, tumor progression, and metastasis...
May 22, 2020: Current Molecular Medicine
Lin Li, Congping Su, Xiangyang Chen, Qing Wang, Wenchao Jiao, Hui Luo, Jiayang Tang, Wei Wang, Sen Li, ShuZhen Guo
Chlorogenic acids (CGAs) have gained considerable attention as pervasive human dietary constituents with potential cardiovascular-preserving effects. The main sources include coffee, yerba mate, Eucommia ulmodies leaves, and Lonicerae Japonicae Flos. CGAs consumption can reduce the risks of hypertension, atherosclerosis, heart failure, myocardial infarction, and other factors associated with cardiovascular risk, such as obesity and type 2 diabetes. This review recapitulates recent advances of CGAs in the cardiovascular-preserving effects, pharmacokinetics, sources and safety...
May 22, 2020: Journal of Agricultural and Food Chemistry
Lijuan Gao, Xiaoqiong Li, Shi Meng, Tengyun Ma, Lihong Wan, Shijun Xu
Purpose: Chlorogenic acid (CGA), a phenolic acid isolated from fruits and vegetables, has been established to have neuroprotective properties in relation to Alzheimer's disease (AD). However, the precise mechanism by which CGA prevents cognitive deficits in AD has not been well studied. This study aimed to explore the potential molecular mechanism of CGA action using an Aβ25-35- induced SH-SY5Y neuron injury and cogxnitive deficits model in APP/PS1 mice. Methods: Three-month-old male APP/PS1 double transgenic mice and a human neuroblastoma cell line (SH-SY5Y) were used to assess the effects of CGA on AD in vivo and in vitro, respectively...
2020: Drug Design, Development and Therapy
Antonia Ebert, Jochem König, Lara Frommer, Detlef Schuppan, George J Kahaly
CONTEXT: The glycoprotein Chromogranin A (CgA) is expressed by endocrine and neuroendocrine cells. High levels of serum CgA serve as marker of neuroendocrine tumors (NET), but its role in autoimmunity has not been assessed. OBJECTIVE: Investigate CgA utility as marker of endocrine autoimmunity. METHODS: CgA serum levels were evaluated in 807 consecutive unselected subjects (cross-sectional study) with the Time-Resolved Amplified Cryptate Emission Technology...
May 21, 2020: Journal of Clinical Endocrinology and Metabolism
Jie-Fei Bai, Hui-Xiu Han, Ru Feng, Jiang-Tao Li, Ting Wang, Chun-Li Zhang, Hui Liu
BACKGROUND: We aimed to validate a simple Comprehensive Geriatric Assessment (CGA) in older adults with diffuse large B-cell lymphoma (DLBCL) in China and to evaluate the tolerability and efficacy of CGA-driven therapy. MATERIALS AND METHODS: In total, 78 patients with DLBCL aged ≥60 years were evaluated using CGA with the following parameters: age ≥ 80 years, activities of daily living (ADL), instrumental ADL, and modified cumulative illness rating score for geriatrics...
May 20, 2020: Oncologist
Maroun Rizkallah, Amer Sebaaly, Khalil Kharrat, Gaby Kreichati
Study Design: Retrospective cohort. Objectives: To evaluate the long-term effect of convex growth arrest (CGA) on coronal deformity correction in congenital scoliosis. Methods: Twenty-two patients with congenital scoliosis operated by 1-staged double approach hemiephysiodesis by bone grafting of the convex side without instrumentation are included. Eighteen curves had an isolated hemivertebra while 4 curves had congenital bar. Subgroup analysis was performed according to age at surgery (3 years cutoff), type of malformation (hemivertebra vs congenital bar), and severity of curve (35° cutoff)...
June 2020: Global Spine Journal
Ming-Cheng Chang, Yu-Jen Kuo, Kuo-Hsuan Hung, Cheng-Liang Peng, Kuan-Yin Chen, Lung-Kun Yeh
Infectious keratitis is still one of the major causes of visual impairment and blindness, often affecting developing countries. Eye-drop therapy to reduce disease progression is the first line of treatment for infectious keratitis. The current limitations in controlling ophthalmic infections include rapid precorneal drug loss and the inability to provide long-term extraocular drug delivery. The aim of the present study was to develop a novel ophthalmic formulation to treat corneal infection. The formulation was prepared by constructing moxifloxacin (MFX) and dexamethasone (DEX)-loaded nanostructured lipid carriers (Lipo-MFX/DEX) mixed with a collagen/gelatin/alginate (CGA) biodegradable material (CGA-Lipo-MFX/DEX) for prolonged ocular application...
May 20, 2020: Biomedical Materials
Jakub Pobłocki, Anna Jasińska, Anhelli Syrenicz, Elżbieta Andrysiak-Mamos, Małgorzata Szczuko
Nuroendocrine neoplasms (NENs) are a group of rare neoplasms originating from dispersed neuroendocrine cells, mainly of the digestive and respiratory tract, showing characteristic histology and immunoprofile contributing to classification of NENs. Some NENs have the ability to produce biogenic amines and peptide hormones, which may be associated with clinical syndromes like, e.g., the carcinoid syndrome caused by unmetabolized overproduced serotonin, hypoglycemic syndrome in case of insulinoma, or Zollinger-Ellison syndrome accompanying gastrinoma...
May 15, 2020: Nutrients
Min-Gu Kang, Chul-Hwan Kang, Heeyoung Lee, Young-Chul Yoo, You-Rim Lee, Kwang-Il Kim, Cheol-Ho Kim
BACKGROUND: The quality of life of older adults deteriorates when they lose their ability to perform activities of daily living. Therefore, the older adults should be assessed to identify risk factors for functional decline and to correct these factors so that they may live as independently as possible in the community. We developed a medical care model using comprehensive geriatric assessment (CGA) for community-dwelling older patients. METHODS: Three hundred and ninety-one older adults who were frail or likely to be frail were selected...
April 16, 2020: Archives of Gerontology and Geriatrics
Petra Mäkelä, David Stott, Mary Godfrey, Graham Ellis, Rebekah Schiff, Sasha Shepperd
BACKGROUND: There is limited understanding of the contribution made by older people and their caregivers to acute healthcare in the home and how this compares to hospital inpatient healthcare. OBJECTIVES: To explore the work of older people and caregivers at the time of an acute health event, the interface with professionals in a hospital and hospital at home (HAH) and how their experiences relate to the principles underpinning comprehensive geriatric assessment (CGA)...
May 19, 2020: Age and Ageing
Xuequan Hu, Meng Wang, Yangyang Pan, Yingying Xie, Jinhui Han, Xingyun Zhang, Robert Niayale, Honghong He, Qin Li, Tian Zhao, Yan Cui, Sijiu Yu
Endometritis is one of the main diseases which harm sheep husbandry. Astragalin and chlorogenic acid (CGA) are common active ingredients of traditional Chinese medicine (TCM) with immunoprotective, antioxidant, and anti-inflammatory properties. In the present study, sheep endometrial epithelium cells (SEECs) were successfully purified and identified, and the in vitro inflammation model of SEECs induced by Escherichia coli (E. coli) was successfully established. To explore the effect of astragalin and CGA on the inflammation induced by E...
2020: Frontiers in Veterinary Science
Janani Thillainadesan, Minna F Yumol, Sarah Hilmer, Sarah J Aitken, Vasi Naganathan
OBJECTIVES: Managing older patients with surgical conditions is a major challenge for hospitals. There is therefore a growing interest in providing geriatric perioperative services. The aim of this systematic review and meta-analysis was to characterize and assess the impact of targeted perioperative geriatric interventions on clinical outcomes of older adults admitted to nonorthopedic surgical teams. DESIGN, SETTING AND PARTICIPANTS: A systematic review and meta-analysis of studies of perioperative geriatric interventions in older adults hospitalized under nonorthopedic surgical teams...
May 14, 2020: Journal of the American Medical Directors Association
Parvin A Barbhuiya, Arif Uddin, Supriyo Chakraborty
We delineated the pattern of synonymous codon usage bias (CUB) and its determinants in mitochondrial CYB gene of respiratory chain across different amphibian groups namely orders anura, urodela and gymnophiona. We observed that CUB was low in CYB gene of amphibia. The gymnophionans had comparatively high bias followed by urodeles and anurans. The codons namely TCA, CCA, CAA, CGA, TGA, AAA and ACA were over-represented in all three orders. The codons such as GCC and TCC were over-represented in anura whereas in urodela, the over-represented codons were TTA, CTA, ATA, GTA, GAA, GGA and GCA...
May 11, 2020: Gene
Xiaohong Han, Huan He, Haiyan Shen, Jinhan Tang, Wanying Dong, Yufei Shi, Songqing Wu, Feiping Zhang, Guanghong Liang
Dendrolimus houi is one of the most common caterpillars infesting Gymnosperm trees, and widely distributed in several countries in Southeast Asia, and exists soley or coexists with several congeners and some Lasiocampidae species in various forest habitats. However, natural hybrids occasionally occur among some closely related species in the same habitat, and host preference, extreme climate stress, and geographic isolation probably lead to their uncertain taxonomic consensus. The mitochondrial DNA (mtDNA) of D...
2020: PloS One
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