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JOURNAL ARTICLE
Shuangshuang Sun, Lin Li, Mengying Xu, Ying Wei, Feng Shi, Song Liu
PURPOSE: To analyze the clinicopathologic information and CT imaging features of Epstein-Barr virus (EBV)-positive gastric cancer (GC) and establish CT-based radiomics models to predict the EBV status of GC. METHODS: This retrospective study included 144 GC cases, including 48 EBV-positive cases. Pathological and immunohistochemical information was collected. CT enlarged LN and morphological characteristics were also assessed. Radiomics models were constructed to predict the EBV status, including decision tree (DT), logistic regression (LR), random forest (RF), and support vector machine (SVM)...
April 24, 2024: Abdominal Radiology
#2
JOURNAL ARTICLE
Lauren G Bailes, Abigail Blum, Whitney Barnett, Hannah Piersiak, Sydney Takemoto, Brooke Fleming, Caelan Alexander, Kathryn L Humphreys
Caregivers' mental representations of their children can be assessed prenatally and are prospectively associated with later caregiving quality and caregiver-child attachment. Compared to balanced, distorted or disengaged representations are linked to insecure caregiver-child attachments. The present study explored factors (i.e. stressful life experiences and positive experiences) that may be linked to risk for distorted and disengaged representations. We used a brief version of the Prenatal Working Model of the Child Interview in a sample of 298 pregnant people (ages 19 to 45 years; M = 30...
April 24, 2024: Attachment & Human Development
#3
JOURNAL ARTICLE
Meng-Shu Hao, Scott Mazurkewich, He Li, Alma Kvammen, Srijani Saha, Salla Koskela, Annie R Inman, Masahiro Nakajima, Nobukiyo Tanaka, Hiroyuki Nakai, Gisela Brändén, Vincent Bulone, Johan Larsbrink, Lauren S McKee
Carbohydrate-binding modules (CBMs) are non-catalytic proteins found appended to carbohydrate-active enzymes. Soil and marine bacteria secrete such enzymes to scavenge nutrition, and they often use CBMs to improve reaction rates and retention of released sugars. Here we present a structural and functional analysis of the recently established CBM family 92. All proteins analysed bind preferentially to β-1,6-glucans. This contrasts with the diversity of predicted substrates among the enzymes attached to CBM92 domains...
April 23, 2024: Nature Communications
#4
JOURNAL ARTICLE
Zoe Grabinski, Kar-Mun Woo, Olumide Akindutire, Cassidy Dahn, Lauren Nash, Inna Leybell, Yelan Wang, Danielle Bayer, Jordan Swartz, Catherine Jamin, Silas W Smith
BACKGROUND: Review of emergency department (ED) revisits with admission allows the identification of improvement opportunities. Applying a health equity lens to revisits may highlight potential disparities in care transitions. Universal definitions or practicable frameworks for these assessments are lacking. The authors aimed to develop a structured methodology for this quality assurance (QA) process, with a layered equity analysis. METHODS: The authors developed a classification instrument to identify potentially preventable 72-hour returns with admission (PPRA-72), accounting for directed, unrelated, unanticipated, or disease progression returns...
March 15, 2024: Joint Commission Journal on Quality and Patient Safety
#5
Amy C Moreno, Erin E Watson, Laia Humbert-Vidan, Douglas E Peterson, Lisanne V van Dijk, Teresa Guerrero Urbano, Lisa Van den Bosch, Andrew J Hope, Matthew S Katz, Frank J P Hoebers, Ruth A Aponte Wesson, James E Bates, Paolo Bossi, Adeyinka F Dayo, Mélanie Doré, Eduardo Rodrigues Fregnani, Thomas J Galloway, Daphna Y Gelblum, Issa A Hanna, Christina E Henson, Sudarat Kiat-Amnuay, Anke Korfage, Nancy Y Lee, Carol M Lewis, Charlotte Duch Lynggaard, Antti A Mäkitie, Marco Magalhaes, Yvonne M Mowery, Carles Muñoz-Montplet, Jeffrey N Myers, Ester Orlandi, Jaymit Patel, Jillian M Rigert, Deborah Saunders, Jonathan D Schoenfeld, Ugur Selek, Efsun Somay, Vinita Takiar, Juliette Thariat, Gerda M Verduijn, Alessandro Villa, Nick West, Max J H Witjes, Alex Won, Mark E Wong, Christopher M K L Yao, Simon W Young, Kamal Al-Eryani, Carly E A Barbon, Doke J M Buurman, François J Dieleman, Theresa M Hofstede, Abdul Ahad Khan, Adegbenga O Otun, John C Robinson, Lauren Hum, Jorgen Johansen, Rajesh Lalla, Alexander Lin, Vinod Patel, Richard J Shaw, Mark S Chambers, Daniel Ma, Mabi Singh, Noam Yarom, Abdallah Sherif Radwan Mohamed, Katherine A Hutcheson, Stephen Y Lai, Clifton David Fuller
PURPOSE: Osteoradionecrosis of the jaw (ORNJ) is a severe iatrogenic disease characterized by bone death after radiation therapy (RT) to the head and neck. With over 9 published definitions and at least 16 diagnostic/staging systems, the true incidence and severity of ORNJ are obscured by lack of a standard for disease definition and severity assessment, leading to inaccurate estimation of incidence, reporting ambiguity, and likely under-diagnosis worldwide. This study aimed to achieve consensus on an explicit definition and phenotype of ORNJ and related precursor states through data standardization to facilitate effective diagnosis, monitoring, and multidisciplinary management of ORNJ...
April 9, 2024: medRxiv
#6
JOURNAL ARTICLE
Feng Yan, Bornface Mutembei, Trisha Valerio, Gokhan Gunay, Ji-Hee Ha, Qinghao Zhang, Chen Wang, Ebenezer Raj Selvaraj Mercyshalinie, Zaid A Alhajeri, Fan Zhang, Lauren E Dockery, Xinwei Li, Ronghao Liu, Danny N Dhanasekaran, Handan Acar, Wei R Chen, Qinggong Tang
Optical coherence tomography (OCT) is an ideal imaging technique for noninvasive and longitudinal monitoring of multicellular tumor spheroids (MCTS). However, the internal structure features within MCTS from OCT images are still not fully utilized. In this study, we developed cross-statistical, cross-screening, and composite-hyperparameter feature processing methods in conjunction with 12 machine learning models to assess changes within the MCTS internal structure. Our results indicated that the effective features combined with supervised learning models successfully classify OVCAR-8 MCTS culturing with 5,000 and 50,000 cell numbers, MCTS with pancreatic tumor cells (Panc02-H7) culturing with the ratio of 0%, 33%, 50%, and 67% of fibroblasts, and OVCAR-4 MCTS treated by 2-methoxyestradiol, AZD1208, and R-ketorolac with concentrations of 1, 10, and 25 µM...
April 1, 2024: Biomedical Optics Express
#7
JOURNAL ARTICLE
Elizabeth M Berrigan, Lin Wang, Hannah Carrillo, Kimberly Echegoyen, Mikayla Kappes, Jorge Torres, Angel Ai-Perreira, Erica McCoy, Emily Shane, Charles D Copeland, Lauren Ragel, Charidimos Georgousakis, Sanghwa Lee, Dawn Reynolds, Avery Talgo, Juan Gonzalez, Ling Zhang, Ashish B Rajurkar, Michel Ruiz, Erin Daniels, Liezl Maree, Shree Pariyar, Wolfgang Busch, Talmo D Pereira
Image segmentation is commonly used to estimate the location and shape of plants and their external structures. Segmentation masks are then used to localize landmarks of interest and compute other geometric features that correspond to the plant's phenotype. Despite its prevalence, segmentation-based approaches are laborious (requiring extensive annotation to train) and error-prone (derived geometric features are sensitive to instance mask integrity). Here, we present a segmentation-free approach that leverages deep learning-based landmark detection and grouping, also known as pose estimation...
2024: Plant phenomics: a science partner journal
#8
JOURNAL ARTICLE
Isaac L Alter, Lauren H Tucker, Jacqueline M Dragon, Maeher R Grewal, Alice Saperstein, T Scott Stroup, Alice A Medalia, Justin S Golub
OBJECTIVE: To explore whether there is an association between serious mental illness (SMI) and hearing loss (HL) among US Hispanic adults. STUDY DESIGN AND SETTING: Cross-sectional epidemiological study (Hispanic Community Health Study), including multicentered US volunteers. METHODS: Multivariable linear regressions were conducted to study the association between SMI and HL. Adjustments were made for potential confounders including age, sex, education, vascular disease (hypertension or diabetes mellitus), and cognition...
April 12, 2024: Otolaryngology—Head and Neck Surgery
#9
JOURNAL ARTICLE
Steven T Chen, Yevgeniy R Semenov, Allireza Alloo, Daniel Q Bach, Allison Betof Warner, Amina Bougrine, Leeann Burton, Laura C Cappelli, Mariana Castells, Justine Cohen, Anna K Dewan, Riley Fadden, Lauren Guggina, Aparna Hegde, Victor Huang, Douglas B Johnson, Benjamin Kaffenberger, Daniela Kroshinsky, Shawn Kwatra, Bernice Kwong, Mario E Lacouture, Cecilia Larocca, Jonathan Leventhal, Alina Markova, Jon McDunn, Meghan J Mooradian, Jarushka Naidoo, Jennifer Choi, Vinod Nambudiri, Caroline A Nelson, Anisha B Patel, Julia Pimkina, Johnathan Rine, Krista M Rubin, Maxwell Sauder, Sheila Shaigany, Afreen Shariff, Ryan J Sullivan, Leyre Zubiri, Kerry L Reynolds, Nicole R LeBoeuf
With an increasing number of patients eligible for immune checkpoint inhibitors, the incidence of immune-related adverse events (irAEs) is on the rise. Dermatologic immune-related adverse events (D-irAEs) are the most common and earliest to manifest, often with important downstream consequences for the patient. Current guidelines lack clarity in terms of diagnostic criteria for D-irAEs. The goal of this project is to better define D-irAE for the purposes of identification, diagnosis, and future study of this important group of diseases...
April 10, 2024: Journal for Immunotherapy of Cancer
#10
JOURNAL ARTICLE
Nicolai Kjældgaard Kristensen, Laurens Manning, Jeppe Lange, Joshua S Davis
BACKGROUND: Periprosthetic Joint Infection (PJI) is a devastating complication in hip and knee joint arthroplasty. The "JS BACH" classification system was developed in 2021 to stratify the complexity of PJI, and more importantly, to act as a tool to guide referrals to specialist centers. The "JS BACH" classification has not been validated in an external cohort. This study aimed to do so using a large prospective cohort from Australia and New Zealand. METHODS: We applied the JS-BACH classification to the Prosthetic Joint Infection in Australia and New Zealand Observational (PIANO) cohort...
April 8, 2024: Journal of Arthroplasty
#11
JOURNAL ARTICLE
Joseph Matthew Holden, Lauren Katie Wareham, David John Calkins
Astrocytes throughout the central nervous system are heterogeneous in both structure and function. This diversity leads to tissue-specific specialization where morphology is adapted to the surrounding neuronal circuitry, as seen in Bergman glia of the cerebellum and Müller glia of the retina. Because morphology can be a differentiating factor for cellular classification, we recently developed a mouse where glial-fibrillary acidic protein (GFAP)-expressing cells stochastically label for full membranous morphology...
April 9, 2024: Glia
#12
JOURNAL ARTICLE
Alexander Troester, Julia Kohn, Qi Wang, Lauren Weaver, Imran Hassan, Wolfgang Gaertner, Schelomo Marmor, Paolo Goffredo
BACKGROUND: Anal adenocarcinoma is rare with no standardized treatment regimen or staging system. Therefore, different combinations of chemotherapy, radiation, and surgery are used in management. Within the staging system, tumor stage can be based on the depth of invasion, as for rectal adenocarcinoma, or size, as in anal squamous cell carcinoma. This study aimed to analyze patterns of care and clinically available staging systems for anal adenocarcinoma using a national database. METHODS: Adults diagnosed with anal adenocarcinoma were identified in the Surveillance, Epidemiology, and End Results database (2004-2019)...
April 2024: Journal of Gastrointestinal Surgery
#13
JOURNAL ARTICLE
Jacob G Eide, Rijul S Kshirsagar, Chris Wen, Anas Qatanani, Jacob Harris, Lauren Sellers, Eric H Abello, Jennifer E Douglas, James N Palmer, Nithin D Adappa, Edward C Kuan
OBJECTIVE: Surgical frailty estimates a patient's ability to withstand the physiologic stress of an intervention. There is limited data regarding the impact of frailty on endoscopic cerebrospinal fluid (CSF) leak repair. METHODS: Patients undergoing CSF leak repair at two tertiary academic skull base programs were retrospectively reviewed. Demographic, treatment, and postoperative outcomes data were recorded. Frailty was calculated using validated indices, including the American Society of Anesthesiologists (ASA) classification, Charlson Comorbidity Index (CCI), and the Modified 5-Item Frailty Index (mFI-5)...
April 6, 2024: Laryngoscope
#14
JOURNAL ARTICLE
Luca Cappelletti, Lauren Rekerle, Tommaso Fontana, Peter Hansen, Elena Casiraghi, Vida Ravanmehr, Christopher J Mungall, Jeremy J Yang, Leonard Spranger, Guy Karlebach, J Harry Caufield, Leigh Carmody, Ben Coleman, Tudor I Oprea, Justin Reese, Giorgio Valentini, Peter N Robinson
MOTIVATION: Graph representation learning is a family of related approaches that learn low-dimensional vector representations of nodes and other graph elements called embeddings. Embeddings approximate characteristics of the graph and can be used for a variety of machine-learning tasks such as novel edge prediction. For many biomedical applications, partial knowledge exists about positive edges that represent relationships between pairs of entities, but little to no knowledge is available about negative edges that represent the explicit lack of a relationship between two nodes...
2024: Bioinform Adv
#15
JOURNAL ARTICLE
Dominick J Lemas, Xinsong Du, Masoud Rouhizadeh, Braeden Lewis, Simon Frank, Lauren Wright, Alex Spirache, Lisa Gonzalez, Ryan Cheves, Marina Magalhães, Ruben Zapata, Rahul Reddy, Ke Xu, Leslie Parker, Chris Harle, Bridget Young, Adetola Louis-Jaques, Bouri Zhang, Lindsay Thompson, William R Hogan, François Modave
The objective of this study is to develop and evaluate natural language processing (NLP) and machine learning models to predict infant feeding status from clinical notes in the Epic electronic health records system. The primary outcome was the classification of infant feeding status from clinical notes using Medical Subject Headings (MeSH) terms. Annotation of notes was completed using TeamTat to uniquely classify clinical notes according to infant feeding status. We trained 6 machine learning models to classify infant feeding status: logistic regression, random forest, XGBoost gradient descent, k-nearest neighbors, and support-vector classifier...
April 3, 2024: Scientific Reports
#16
JOURNAL ARTICLE
Nina D Fisher, Lauren A Merrell, Sara J Solasz, Abhishek Ganta, Sanjit R Konda, Kenneth A Egol
BACKGROUND: The purpose of this study was to determine if the presence of a standing Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, psychiatric diagnosis is associated with worse outcomes for patients who develop a confirmed fracture-related infection (FRI). MATERIALS AND METHODS: Included patients had open or closed fractures managed with internal fixation and had confirmed FRIs. Baseline demographics, injury information, and outcomes were collected via chart review...
April 4, 2024: Orthopedics
#17
JOURNAL ARTICLE
Tao Pang, Ming Ming Nie, Lei Fan, Jia Yang Wang, Zhao Rui Liu, Yin Yi Qin, Kai Yin
BACKGROUND: The optimal proximal margin (PM) length for Siewert II/III adenocarcinoma of the esophagogastric junction (AEJ) remains unclear. This study aimed to determine the optimal PM length using an abdominal approach to guide surgical decision-making. METHODS: A prospective study analyzed 304 consecutive patients diagnosed with Siewert II/III AEJ between January 2019 and December 2021. Total gastrectomy was performed via the abdominal approach, and PM length was measured on fixed gross specimens...
April 1, 2024: Asian Journal of Surgery
#18
JOURNAL ARTICLE
Arnault Tauziède-Espariat, Julien Masliah-Planchon, Philipp Sievers, Felix Sahm, Volodia Dangouloff-Ros, Nathalie Boddaert, Lauren Hasty, Oumaima Aboubakr, Alice Métais, Fabrice Chrétien, Alexandre Roux, Johan Pallud, Thomas Blauwblomme, Kévin Beccaria, Franck Bourdeaut, Stéphanie Puget, Pascale Varlet
Meningioangiomatosis (MAM) remains a poorly understood lesion responsible for epileptic disease. In the past, MAM was primarily described in the context of neurofibromatosis type 2 before being mainly reported sporadically. Moreover, the malformative or tumoral nature is still debated. Because a subset of MAM are associated with meningiomas, some authors argue that MAM corresponds to an infiltration pattern of these tumors. For these reasons, MAM has not been added to the World Health Organization (WHO) Classification of Central Nervous System Tumors as a specific entity...
April 2, 2024: Brain Pathology
#19
JOURNAL ARTICLE
Matthieu Groh, Laurène Fenwarth, Mathilde Labro, Augustin Boudry, Elise Fournier, Mathieu Wemeau, Alice Marceau-Renaut, Rafael Daltro de Oliveira, Julie Abraham, Marly Barry, Philippe Blanche, Quentin Bodard, Thorsten Braun, Safia Chebrek, Matthieu Decamp, Cécile-Audrey Durel, Edouard Forcade, Mathieu Gerfaud-Valentin, Camille Golfier, Clément Gourguechon, Nathalie Grardel, Olivier Kosmider, Nihal Martis, Sarah Melboucy Belkhir, Fatiha Merabet, Adrien Michon, Stéphane Moreau, Cécile Morice, Antoine Néel, Franck E Nicolini, Laurent Pascal, Florence Pasquier, Andrea Pieragostini, Catherine Roche-Lestienne, Philippe Rousselot, Louis Terriou, Anne Thiebaut-Bertrand, Jean-François Viallard, Claude Preudhomme, Jean-Emmanuel Kahn, Guillaume Lefevre, Nicolas Duployez
We investigated using a custom NGS panel of 149 genes the mutational landscape of 64 consecutive adult patients with tyrosine kinase fusion-negative hypereosinophilia (HE)/hypereosinophilic syndrome (HES) harboring features suggestive of myeloid neoplasm. At least one mutation was reported in 50/64 (78%) patients (compared to 8/44 (18%) patients with idiopathic HE/HES/HEUS used as controls; p < .001). Thirty-five patients (54%) had at least one mutation involving the JAK-STAT pathway, including STAT5B (n = 18, among which the hotspot N642H, n = 13), JAK1 (indels in exon 13, n = 5; V658F/L, n = 2), and JAK2 (V617F, n = 6; indels in exon 13, n = 2)...
April 2, 2024: American Journal of Hematology
#20
Yining Hua, Suzanne Blackley, Ann Shinn, Joseph Skinner, Lauren Moran, Li Zhou
Early and accurate diagnosis is crucial for effective treatment and improved outcomes, yet identifying psychotic episodes presents significant challenges due to its complex nature and the varied presentation of symptoms among individuals. One of the primary difficulties lies in the underreporting and underdiagnosis of psychosis, compounded by the stigma surrounding mental health and the individuals' often diminished insight into their condition. Existing efforts leveraging Electronic Health Records (EHRs) to retrospectively identify psychosis typically rely on structured data, such as medical codes and patient demographics, which frequently lack essential information...
March 21, 2024: Research Square
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