Melissa V Chan, Ming-Huei Chen, Florian Thibord, Bongani B Nkambule, Amber R Lachapelle, Joseph Grech, Zoe E Schneider, Catherine Wallace de Melendez, Jennifer E Huffman, Melissa A Hayman, Harriet E Allan, Paul C Armstrong, Timothy D Warner, Andrew D Johnson
BACKGROUND: Assessment of platelet function is key in diagnosing bleeding disorders and evaluating antiplatelet drug efficacy. However, there is a prevailing "one-size-fits-all" approach in the interpretation of measures of platelet reactivity, with arbitrary cutoffs often derived from healthy volunteer responses. OBJECTIVES: Our aim was to compare well-used platelet reactivity assays. METHODS: Blood and platelet-rich plasma obtained from the Framingham Heart Study ( N = 3429) were assayed using a range of agonists in 5 platelet assays: light transmission aggregometry, Optimul aggregometry, Multiplate impedance aggregometry (Roche Diagnostics), Total Thrombus-Formation Analysis System, and flow cytometry...
March 2024: Research and Practice in Thrombosis and Haemostasis