Camila Ludke Rossetti, Bruna Lourenconi Alves, Flavia Leticia Martins Pecanha, Aime Franco, Vania Nosé, Everardo Magalhães Carneiro, John I Lew, Ernesto Bernal-Mizrachi, Joao Pedro Werneck de Castro
BACKGROUND: The thyroid gland is susceptible to abnormal epithelial cell growth, often resulting in thyroid dysfunction. The serine-threonine protein kinase mechanistic target of rapamycin (mTOR) regulates cellular metabolism, proliferation, and growth through two different protein complexes, mTORC1 and mTORC2. The PI3K-Akt-mTORC1 pathway's overactivity is well associated with heightened aggressiveness in thyroid cancer, but recent studies indicate the involvement of mTORC2 as well. METHODS: To elucidate mTORC1's role in thyrocytes, we developed a novel mouse model with mTORC1 gain of function in thyrocytes by deleting Tuberous Sclerosis Complex 2 (TSC2), an intracellular inhibitor of mTORC1...
April 25, 2024: Thyroid: Official Journal of the American Thyroid Association