Enoch Lok Him Yuen, Alexandre Y Leary, Marion Clavel, Yasin Tumtas, Azadeh Mohseni, Jierui Zhao, Lorenzo Picchianti, Mostafa Jamshidiha, Pooja Pandey, Cian Duggan, Ernesto Cota, Yasin Dagdas, Tolga O Bozkurt
Plants rely on autophagy and membrane trafficking to tolerate stress, combat infections, and maintain cellular homeostasis. However, the molecular interplay between autophagy and membrane trafficking is poorly understood. Using an AI-assisted approach, we identified Rab3GAP-like (Rab3GAPL) as a key membrane trafficking node that controls plant autophagy negatively. Rab3GAPL suppresses autophagy by binding to ATG8, the core autophagy adaptor, and deactivating Rab8a, a small GTPase essential for autophagosome formation and defense-related secretion...
April 22, 2024: Current Biology: CB