Zhen Peng, Beijie Qi, Zhiwen Luo, Yaying Sun, Xingyu Zhang, Jinrong Lin, Jinhui Pang, Peng Zhang, Zhihu Zhao, Xianwen Wang, Jiwu Chen
As a common musculoskeletal disorder, frozen shoulder is characterized by thickened joint capsule and limited range of motion, affecting 2-5% of the general population and more than 20% of patients with diabetes mellitus. Pathologically, joint capsule fibrosis resulting from fibroblast activation is the key event. The activated fibroblasts are proliferative and contractive, producing excessive collagen. Albeit high prevalence, effective anti-fibrosis modalities, especially fibroblast-targeting therapies, are still lacking...
April 10, 2024: Journal of Nanobiotechnology