Jing Wang, Siu Ping Lam, Bei Huang, Yaping Liu, Jihui Zhang, Mandy W M Yu, Jessie C C Tsang, Li Zhou, Steven W H Chau, Ngan Yin Chan, Joey W Y Chan, Carlos H Schenck, Shirley X Li, Vincent C T Mok, Karen Ka Yan Ma, Anne Yin Yan Chan, Yun Kwok Wing
BACKGROUND: Rapid eye movement (REM) sleep behaviour disorder (RBD) is one of the earliest and most specific prodromes of the α-synucleinopathies including Parkinson's disease (PD). It remains uncertain whether RBD occurring in the context of psychiatric disorders (psy-RBD), although very common, is merely a benign epiphenomenon of antidepressant treatment, or whether it harbours an underlying α-synucleinopathy. We hypothesised that patients with psy-RBD demonstrate a familial predisposition to an α-synucleinopathy...
June 30, 2023: Journal of Neurology, Neurosurgery, and Psychiatry