Jiale Liu, Wentian Song, Xue Gao, Jiaoyan Sun, Chunlei Liu, Li Fang, Ji Wang, Junhua Shi, Yue Leng, Xiaoting Liu, Weihong Min
Food-derived peptides with low molecular weight, high bioavailability, and good absorptivity have been exploited as angiotensin-converting enzyme (ACE) inhibitors. In the present study, in-vitro inhibition kinetics of peanut peptides, in silico screening, validation of ACE inhibitory activity, molecular dynamics (MD) simulations, and HUVEC cells were performed to systematically identify the inhibitory mechanism of ACE interacting with peanut peptides. The results indicate that FPHPP, FPHY, and FPHFD peptides have good thermal, pH, and digestive stability...
April 25, 2024: International Journal of Biological Macromolecules