Chuan Li, Min Jiang, Zhi-Ting Fang, Zhiying Chen, Li Li, Ziying Liu, Junmin Wang, Xiaoping Yin, Jian Wang, Moxin Wu
BACKGROUND: Stroke is an acute cerebrovascular disease in which brain tissue is damaged due to sudden obstruction of blood flow to the brain or the rupture of blood vessels in the brain, which can prompt ischemic or hemorrhagic stroke. After stroke onset, ischemia, hypoxia, infiltration of blood components into the brain parenchyma, and lysed cell fragments, among other factors, invariably increase blood-brain barrier (BBB) permeability, the inflammatory response, and brain edema. These changes lead to neuronal cell death and synaptic dysfunction, the latter of which poses a significant challenge to stroke treatment...
May 2024: CNS Neuroscience & Therapeutics