Jiean Xu, Zhiping Liu, Qiuhua Yang, Qian Ma, Yaqi Zhou, Yongfeng Cai, Dingwei Zhao, Guizhen Zhao, Tammy Lu, Kunfu Ouyang, Mei Hong, Ha Won Kim, Huidong Shi, Jifeng Zhang, David Fulton, Clint Miller, Rajeev Malhotra, Neal L Weintraub, Yuqing Huo
AIM: Abdominal aortic aneurysm (AAA) is a common, serious vascular disease with no effective pharmacological treatment. The nucleoside adenosine plays an important role in modulating vascular homeostasis, which prompted us to determine whether adenosine kinase (ADK), an adenosine metabolizing enzyme, modulates AAA formation via control of intracellular adenosine level, and to investigate the underlying mechanisms. METHODS AND RESULTS: We used a combination of genetic and pharmacological approaches in murine models of AAA induced by calcium chloride (CaCl2) application or angiotensin II (Ang II) infusion to study the role of ADK in the development of AAA...
May 9, 2024: Cardiovascular Research