Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#41
JOURNAL ARTICLE
Ruixu Liu, Ren Ma, Xu Liu, Xiaoqing Zhou, Xin Wang, Tao Yin, Zhipeng Liu
OBJECTIVE: Deep brain transcranial stimulation is used in both research and for the treatment of neuropsychological diseases. Ideally, such stimulation should be non-invasive, and precisely controlled. We propose a temporal-spatial interference magneto-acoustic stimulation (TIMAS) method combining transcranial magneto-acoustical stimulation (TMAS) and temporal interference stimulation (TIS) to achieve such stimulation, using the characteristics of the response of brain neurons to modulated low-frequency oscillation...
July 1, 2022: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
#42
JOURNAL ARTICLE
Barak Rosenzweig, Rennen Haramaty, Tima Davidson, Alon Lazarovich, Asaf Shvero, Miki Haifler, Jonathan Gal, Shay Golan, Sagi Shpitzer, Azik Hoffman, Omri Nativ, Yuval Freifeld, Rani Zreik, Zohar A Dotan
We thank the commenters for their important insights [...].
May 25, 2022: Journal of Personalized Medicine
#43
JOURNAL ARTICLE
Natalia Palazón-Carrión, Alejandro Martín García-Sancho, Esteban Nogales-Fernández, Carlos Jiménez-Cortegana, Fernando Carnicero-González, Eduardo Ríos-Herranz, Fátima de la Cruz-Vicente, Guillermo Rodríguez-García, Rubén Fernández-Álvarez, Natividad Martínez-Banaclocha, Josep Gumà-Padrò, José Gómez-Codina, Antonio Salar-Silvestre, Delvys Rodríguez-Abreu, Laura Gálvez-Carvajal, Jorge Labrador, María Guirado-Risueño, Daniel J García-Domínguez, Lourdes Hontecillas-Prieto, Pablo Espejo-García, Isabel Fernández-Román, Mariano Provencio-Pulla, Margarita Sánchez-Beato, Marta Navarro, Lejeune Marylene, Tomás Álvaro-Naranjo, Maria Casanova-Espinosa, Victor Sánchez-Margalet, Antonio Rueda-Domínguez, Luis de la Cruz-Merino
PURPOSE: New therapeutic options are needed in relapsed/refractory diffuse large B-cell lymphoma (R/R DLBCL). Lenalidomide-based schedules can reverse rituximab refractoriness in lymphoma. PATIENTS AND METHODS: In the phase II R2-GDP trial, 78 patients unsuitable for autologous stem cell transplant received treatment with the following schedule: lenalidomide 10 mg Days (D)1-14, rituximab 375 mg/m2 D1, cisplatin 60 mg/m2 D1, gemcitabine 750 mg/m2 D1 and D8, and dexamethasone 20 mg D1-3, up to 6 cycles (induction phase), followed by lenalidomide 10 mg (or last lenalidomide dose received) D1-21 every 28 days (maintenance phase)...
September 1, 2022: Clinical Cancer Research
#44
JOURNAL ARTICLE
So Yoon Lee, Javier Fierro, Jake Dipasquale, Anthony Bastian, An M Tran, Deawoo Hong, Brandon Chin, Paul J Nguyen-Lee, Sarah Mazal, Jamil Espinal, Tima Thomas, Huanyu Dou
Delivery of plasmid DNA to transfect human primary macrophages is extremely difficult, especially for genetic engineering. Engineering macrophages is imperative for the treatment of many diseases including infectious diseases, cancer, neurological diseases, and aging. Unfortunately, plasmid does not cross the nuclear membranes of terminally differentiated macrophages to integrate the plasmid DNA (pDNA) into their genome. To address this issue, we have developed a core-shell nanoparticle (NP) using our newly created cationic lipid to deliver the anti-inflammatory cytokine IL-4 pDNA (IL-4pDNA-NPs)...
2022: Frontiers in Immunology
#45
JOURNAL ARTICLE
Shaimaa M Badr-Eldin, Hibah M Aldawsari, Nabil A Alhakamy, Usama A Fahmy, Osama A A Ahmed, Thikryat Neamatallah, Singkome Tima, Raghad H Almaghrabi, Fayda M Alkudsi, Asmaa A Alamoudi, Amjad A Alzahrani, Sabna Kotta, Omar D Al-Hejaili
Simvastatin (SMV) is an antihyperlipidemic agent that has been investigated as a possible anti-cancer agent. An obstacle to malignant tumor therapy using drugs is the delivery of adequate levels to the cancer cells while minimizing side effects following their systemic administration. To circumvent this challenge, the researchers directed towards the field of nanotechnology to benefit from the nano-size of the formulation in passively targeting the tumor cells. Thus, our study aimed at investigating the potential of a combined mixture-process variable design for optimization of SMV spanlastics (SMV-SPNs) with minimized particle size and maximized zeta potential to enhance the anticancer activity of the drug...
May 9, 2022: Pharmaceutics
#46
JOURNAL ARTICLE
Ornchuma Naksuriya, Krai Daowtak, Singkome Tima, Siriporn Okonogi, Monika Mueller, Stefan Toegel, Ruttiros Khonkarn
Cyrtosperma johnstonii is one of the most interesting traditional medicines for cancer treatment. This study aimed to compare and combine the biological activities related to cancer prevention of the flavonoid glycosides rutin (RT) and isorhamnetin-3-o-rutinoside (IRR) and their hydrolysis products quercetin (QT) and isorhamnetin (IR) from C. johnstonii extract. ABTS and MTT assays were used to determine antioxidant activity and cytotoxicity against various cancer cells, as well as normal cells. Anti-inflammatory activities were measured by ELISA...
May 18, 2022: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
#47
JOURNAL ARTICLE
Singkome Tima, Tawat Tapingkae, Chaiwat To-Anun, Parinn Noireung, Phikul Intaparn, Wantida Chaiyana, Jakkapan Sirithunyalug, Pawaret Panyajai, Natsima Viriyaadhammaa, Wariya Nirachonkul, Lapamas Rueankham, Win Lae Aung, Fah Chueahongthong, Sawitree Chiampanichayakul, Songyot Anuchapreeda
Golden cordyceps ( Cordyceps militaris ) is a mushroom of the genus Cordyceps . It has been used as a food supplement for both healthy and ill people. In this study, the antileukaemic cell proliferation activities of golden cordyceps extracts were examined and compared with standard cordycepin (CDCP) in EoL-1, U937, and KG-1a cells. Wilms' tumour 1 (WT1) protein was used as a biomarker of leukaemic cell proliferation. The cytotoxicity of the extracts on leukaemic cells was determined using the MTT assay. Their inhibitory effects on WT1 protein expression and cell cycle progression of EoL-1 cells were investigated using Western blotting and flow cytometry, respectively...
2022: Evidence-based Complementary and Alternative Medicine: ECAM
#48
JOURNAL ARTICLE
Michal Eifer, Hodaya Pinian, Eyal Klang, Yousef Alhoubani, Nayroz Kanana, Noam Tau, Tima Davidson, Eli Konen, Onofrio A Catalano, Yael Eshet, Liran Domachevsky
OBJECTIVES: To evaluate if radiomics with machine learning can differentiate between F-18-fluorodeoxyglucose (FDG)-avid breast cancer metastatic lymphadenopathy and FDG-avid COVID-19 mRNA vaccine-related axillary lymphadenopathy. MATERIALS AND METHODS: We retrospectively analyzed FDG-positive, pathology-proven, metastatic axillary lymph nodes in 53 breast cancer patients who had PET/CT for follow-up or staging, and FDG-positive axillary lymph nodes in 46 patients who were vaccinated with the COVID-19 mRNA vaccine...
September 2022: European Radiology
#49
JOURNAL ARTICLE
Barak Rosenzweig, Rennen Haramaty, Tima Davidson, Alon Lazarovich, Asaf Shvero, Miki Haifler, Jonathan Gal, Shay Golan, Sagi Shpitzer, Azik Hoffman, Omri Nativ, Yuval Freifeld, Rani Zreik, Zohar A Dotan
PURPOSE: to evaluate a unique subpopulation of radical prostatectomy (RP) candidates with "negative" prostate 68 Ga-labeled prostate-specific membrane antigen (PSMA) positron emission tomography (PET) computed tomography (CT) imaging scans and to characterize the clinical implications of misleading findings. MATERIALS AND METHODS: This case-control retrospective study compared the final histological outcomes of patients with "negative" pre-RP PSMA PET/CT prostate scans (with a prostate maximal standardized uptake value [SUVmax] below the physiologic uptake) to those with an "intense" prostatic tracer uptake (with a SUVmax above the physiologic uptake)...
March 6, 2022: Journal of Personalized Medicine
#50
JOURNAL ARTICLE
Arosha T Weerakoon, Crystal Cooper, Ian A Meyers, Nicholas Condon, Christopher Sexton, David Thomson, Pauline J Ford, Anne L Symons
OBJECTIVE: To determine the effect of patient age (young or mature), anatomical location (shallow/deep and central/peripheral) and microscopic site (intertubular/peritubular) on dentine mineral density, distribution and composition. METHODS: Extracted posterior teeth from young (aged 19-20 years, N = 4) and mature (aged 54-77 years, N = 4) subjects were prepared to shallow and deep slices. The dentine surface elemental composition was investigated in a SEM using Backscattered Electron (BSE) micrographs, Energy Dispersive X-ray Spectroscopy, and Integrated Mineral Analysis...
2022: Journal of structural biology: X
#51
JOURNAL ARTICLE
Pawaret Panyajai, Fah Chueahongthong, Natsima Viriyaadhammaa, Wariya Nirachonkul, Singkome Tima, Sawitree Chiampanichayakul, Songyot Anuchapreeda, Siriporn Okonogi
Zingiber ottensii, is widely used in Asian traditional remedies for the treatment of many diseases. The present study explores anticancer activity of Z. ottensii essential oil (ZOEO) and its nanoformulations. ZOEO obtained from hydrodistillation of Z. ottensii fresh rhizomes was analysis using gas chromatography mass spectroscopy. Zerumbone (25.21%) was the major compound of ZOEO followed by sabinene (23.35%) and terpene-4-ol (15.97%). Four types of ZOEO loaded nanoformulations; nanoemulsion, microemulsion, nanoemulgels, and microemulgel, were developed...
2022: PloS One
#52
REVIEW
Jacopo J V Branca, Alfredo Lascialfari Bruschi, Antonino Marcello Pilia, Donatello Carrino, Giulia Guarnieri, Massimo Gulisano, Alessandra Pacini, Ferdinando Paternostro
Background : The "classic" thyroid gland arterial vascularization takes into account two superior thyroid arteries (STA), two inferior thyroid arteries (ITA) and, occasionally, a thyroid ima artery (TIMA). The present review focuses on exploring the available data concerning thyroid gland arterial vascularization and its variations. Methods : Here, we analysed 49 articles from the last century, ranging from case reports to reviews concerning cadaver dissection classes, surgical intervention, and non-invasive techniques as well...
January 17, 2022: Medicina
#53
JOURNAL ARTICLE
Giovanni Damiani, Giulia Odorici, Alessia Pacifico, Aldo Morrone, Rosalynn R Z Conic, Tima Davidson, Abdulla Watad, Paolo D M Pigatto, Delia Colombo, Piergiorgio Malagoli, Marco Fiore
Since psoriasis (PsO) is a chronic inflammatory disease, patients may experience a drug failure also with very effective drugs (i.e., secukinumab) and, consequently, dermatologists have two therapeutic options: switching or perform a combination therapy (rescue therapy) to save the drug that had decreased its efficacy. At the moment no studies focused on combination/rescue therapy of secukinumab, so we performed a 52-weeks multicenter retrospective observational study that involved 40 subjects with plaque psoriasis that experienced a secondary failure and were treated with combination therapy (ciclosporin ( n = 11), MTX ( n = 15), NB-UVB ( n = 7) and apremilast ( n = 7))...
January 14, 2022: Pharmaceuticals
#54
JOURNAL ARTICLE
Tima Antony, Kajal Chakraborty, Shubhajit Dhara
Dipeptidyl-peptidase-4 is a multifunctional ectoenzyme, which is implicated with hyperglycemic pathophysiology. Therefore, dipeptidyl-peptidase-4 inhibitors could be used as an attractive therapeutic strategy in blood-glucose homeostasis to attenuate the pathophysiologies of diabetes. A sulfated galactofucan characterized as [→1)- O -4-sulfonato- α -fucopyranosyl-(2→1)- O -2-sulfonato- α -fucopyranose-(3→] along with a branch of [→1)-6- O -methyl- β -galactopyranosyl-(4→] unit at the C-4 position of O -2-sulfonato- α -fucopyranose, isolated from the seaweed Padina tetrastromatica , exhibited prospective attenuation property against dipeptidyl-peptidase-4 (IC50 0...
January 17, 2022: Natural Product Research
#55
JOURNAL ARTICLE
Antanas Zinovicius, Juste Rozene, Timas Merkelis, Ingrida Bruzaite, Arunas Ramanavicius, Inga Morkvenaite-Vilkonciene
Electrically conductive polymers are promising materials for charge transfer from living cells to the anodes of electrochemical biosensors and biofuel cells. The modification of living cells by polypyrrole (PPy) causes shortened cell lifespan, burdens the replication process, and diminishes renewability in the long term. In this paper, the viability and morphology non-modified, inactivated, and PPy-modified yeasts were evaluated. The results displayed a reduction in cell size, an incremental increase in roughness parameters, and the formation of small structural clusters of polymers on the yeast cells with the increase in the pyrrole concentration used for modification...
January 2, 2022: Sensors
#56
JOURNAL ARTICLE
Tetsuo Sugishita, Shunsuke Tsukamoto, Jun Imaizumi, Yasuyuki Takamizawa, Manabu Inoue, Konosuke Moritani, Yusuke Kinugasa, Yukihide Kanemitsu
BACKGROUND: There is no clear evidence on the number of cases required to master the techniques required in robot-assisted surgery for different surgical fields and techniques. The purpose of this study was to clarify the learning curve of robot-assisted rectal surgery for malignant disease by surgical process. METHOD: The study retrospectively analyzed robot-assisted rectal surgeries performed between April 2014 and July 2020 for which the operating time per process was measurable...
January 3, 2022: Surgical Endoscopy
#57
JOURNAL ARTICLE
Hani Z Asfour, Usama A Fahmy, Waleed S Alharbi, Alshaimaa M Almehmady, Abdulmohsin J Alamoudi, Singkome Tima, Rasha A Mansouri, Ulfat M Omar, Osama A A Ahmed, Shadi A Zakai, Ahmed A Aldarmahi, Alaa Bagalagel, Reem Diri, Nabil A Alhakamy
Lung cancer is a dangerous type of cancer in men and the third leading cause of cancer-related death in women, behind breast and colorectal cancers. Thymoquinone (THQ), a main compound in black seed essential oils, has a variety of beneficial effects, including antiproliferative, anti-inflammatory, and antioxidant properties. On the other hand, scorpion venom peptides (SV) induce apoptosis in the cancer cells, making it a promising anticancer agent. THQ, SV, and Phospholipon® 90H (PL) were incorporated in a nano-based delivery platform to assess THQ's cellular uptake and antiproliferative efficacy against a lung cancer cell line derived from human alveolar epithelial cells (A549)...
December 13, 2021: Pharmaceutics
#58
JOURNAL ARTICLE
Tima Davidson, Yonatan Yakobi, Knaana Nayruz, Gabriel Levin, Jacob Korach, Tamar Perri
INTRODUCTION: Radical hysterectomy for early cervical cancer is associated with post-operative bladder dysfunction. Post-operative imaging by 18F-FDG PET/CT scanning is often performed to rule out recurrence. Since women are instructed to empty the bladder before imaging, we aim to study if scanned abnormal residual bladder volume is associated with future urinary symptoms. METHODS: Women who underwent radical hysterectomy for cervical cancer between July 2010 and January 2019 were included in the study...
December 14, 2021: Minerva obstetrics and gynecology
#59
JOURNAL ARTICLE
Wariya Nirachonkul, Siriporn Ogonoki, Tarika Thumvijit, Supanimit Chiampanichayakul, Pawaret Panyajai, Songyot Anuchapreeda, Singkome Tima, Sawitree Chiampanichayakul
Acute myeloblastic leukemia (AML) is a disease with a high rate of relapse and drug resistance due to the remaining leukemic stem cells (LSCs). Therefore, LSCs are specific targets for the treatment of leukemia. CD123 is specifically expressed on LSCs and performs as a specific marker. Curcumin is the main active compound of a natural product with low toxicity for humans. It has been reported to inhibit leukemic cell growth. However, curcumin is practically insoluble in water and has low bioavailability. In this study, we aimed to formulate curcumin nanoparticles and conjugate with the anti-CD123 to overcome the low water solubility and improve the targeting of LSCs...
November 5, 2021: Nanomaterials
#60
JOURNAL ARTICLE
Milena Tocut, Tima Davidson, Rebecca Leibu, Howard Amital, Yehuda Shoenfeld, Ora Shovman
No abstract text is available yet for this article.
November 2021: Israel Medical Association Journal: IMAJ
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
