Dohyeon Kim, Chang-Hee Whang, Jungwoo Hong, Monica Celine Prayogo, Wonsik Jung, Seojung Lee, Hocheol Shin, Yujin Kim, Jiyoung Yu, Min Joong Kim, Kyunggon Kim, Hee-Seung Lee, Sangyong Jon
Organ-selective drug delivery is expected to maximize the efficacy of various therapeutic modalities while minimizing their systemic toxicity. Lipid nanoparticles and polymersomes can direct the organ-selective delivery of mRNAs or gene editing machineries, but their delivery is limited to mostly liver, spleen, and lung. A platform that enables delivery to these and other target organs is urgently needed. Here, a library of glycocalyx-mimicking nanoparticles (GlyNPs) comprising five randomly combined sugar moieties is generated, and direct in vivo library screening is used to identify GlyNPs with preferential biodistribution in liver, spleen, lung, kidneys, heart, and brain...
March 15, 2024: Advanced Materials