Joseph R Visker, Ben J Brintz, Christos P Kyriakopoulos, Yanni Hillas, Iosif Taleb, Rachit Badolia, Thirupura S Shankar, Junedh M Amrute, Jing Ling, Rana Hamouche, Eleni Tseliou, Sutip Navankasattusas, Omar Wever-Pinzon, Gregory S Ducker, William L Holland, Scott A Summers, Steven C Koenig, Thomas C Hanff, Kory J Lavine, Srinivas Murali, Stephen Bailey, Rami Alharethi, Craig H Selzman, Palak Shah, Mark S Slaughter, Manreet K Kanwar, Stavros G Drakos
Mechanical unloading and circulatory support with left ventricular assist devices (LVADs) mediate significant myocardial improvement in a subset of advanced heart failure (HF) patients. The clinical and biological phenomena associated with cardiac recovery are under intensive investigation. Left ventricular (LV) apical tissue, alongside clinical data, were collected from HF patients at the time of LVAD implantation (n=208). RNA was isolated and mRNA transcripts were identified through RNA sequencing and confirmed with RT-qPCR...
April 20, 2024: bioRxiv