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https://read.qxmd.com/read/30786069/performance-improvement-of-plasmonic-sensors-using-a-combination-of-ac-electrokinetic-effects-for-bio-target-capture
#1
Quentin Avenas, Julien Moreau, Marion Costella, Arbi Maalaoui, Abdelkader Souifi, Paul Charette, Julien Marchalot, Marie Frénéa-Robin, Michael Canva
Analytes concentration techniques are being developed with the appealing expectation to boost the performance of biosensors. One promising method lies in the use of electrokinetic forces. We present hereafter a new design for a microstructured plasmonic sensor which is obtained by conventional microfabrication techniques, and which can easily be adapted on a classical surface plasmon resonance imaging (SPRI) system without further significant modification. Dielectrophoretic trapping and electro-osmotic displacement of the targets in the scanned fluid are performed through interdigitated 200 μm wide gold electrodes that also act as the SPR-sensing substrate...
February 20, 2019: Electrophoresis
https://read.qxmd.com/read/30785140/a-novel-electrochemical-strategy-based-on-porous-3d-graphene-starch-architecture-and-silver-deposition-for-ultrasensitive-detection-of-neuron-specific-enolase
#2
Yishan Fang, Yanping Li, Ming Zhang, Bo Cui, Qiong Hu, Lishi Wang
This work was aimed at designing a novel and ultrasensitive electrochemical immunoassay strategy to detect neuron-specific enolase (NSE) with a triple signal amplification strategy. A greatly enhanced sensitive detection of NSE was achieved by using porous three-dimensional graphene-starch architecture (3D-GNS) modified on the immunosensor's surface to construct a unique 3D immunoelectrode, which would greatly accelerate electron transfer and capture more protein molecules. 3D-GNS was prepared with starch as a crosslinking agent and stabilizer, which is biocompatible and environmentally friendly...
February 20, 2019: Analyst
https://read.qxmd.com/read/30784336/severe-asthma-and-bronchiectasis
#3
Marta García-Clemente, Ana Isabel Enríquez-Rodríguez, Marta Iscar-Urrutia, Beatriz Escobar-Mallada, Miguel Arias-Guillén, Francisco Julián López-González, Claudia Madrid-Carbajal, Liliana Pérez-Martínez, Teresa Gonzalez-Budiño
OBJECTIVE: The aim of our study was to determine the tomographic findings and prevalence of bronchiectasis in our population of patients with severe asthma, and to identify factors associated with the presence of bronchiectasis in these patients. MATERIALS AND METHODS: We retrospectively collected data from the medical histories of patients referred to the asthma unit of our hospital, with a diagnosis of severe asthma between 2015 and 2017. Patients with ABPA, cystic fibrosis, immunodeficiency or systemic disease were excluded...
February 20, 2019: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://read.qxmd.com/read/30784263/triphenyl-phosphonium-tpp-derived-protein-sulfenic-acid-trapping-agents-synthesis-reactivity-and-effect-on-mitochondrial-function
#4
Zhe Li, Tom E Forshaw, Reetta J Holmila, Stephen A Vance, Hanzhi Wu, Leslie B Poole, Cristina M Furdui, S Bruce King
Redox mediated protein modifications control numerous processes in both normal and disease metabolism. Protein sulfenic acids, formed from the oxidation of protein cysteine residues, play a critical role in thiol-based redox signaling. The reactivity of protein sulfenic acids requires their identification through chemical trapping and this paper describes the use of the triphenyl phosphonium ion to direct known sulfenic acid traps to the mitochondria, a verified source of cellular reactive oxygen species. Coupling of the triphenyl phosphonium (TPP) group with the 2, 4-(dioxocyclohexyl)propoxy (DCP) unit and the bicyclo[6...
February 20, 2019: Chemical Research in Toxicology
https://read.qxmd.com/read/30784151/a-main-group-element-radical-based-one-dimensional-magnetic-chain
#5
Rui Feng, Li Zhang, Huapeng Ruan, Yue Zhao, Gengwen Tan, Xinping Wang
The first main-group element radical based one-dimensional magnetic chain (1K)n was realized by one-electron reduction of the pyridinyl functionalized borane 1 with elemental potassium in THF in the absence of 18-crown-6 (18-c-6). The electron spin density of (1K)n mainly resides at the boron centers with a considerable contribution from central benzene and pyridine moieties. The spin centers exhibit an antiferromagnetic interaction as demonstrated by magnetic measurements and theoretical calculations. In contrast, the reduction in the presence of 18-c-6 afforded the separated radical anion salt 1K(Crown), in which the potassium cation was trapped by THF and 18-c-6 molecules...
February 19, 2019: Angewandte Chemie
https://read.qxmd.com/read/30783645/tritium-trapping-and-migration-mechanisms-in-li-2-o-a-first-principles-study
#6
Xin Xiang, Guikai Zhang, Feilong Yang, Tao Tang
The tritium recovery behaviors and related mechanisms in lithium-based breeding materials are the major concerns in fusion reactors. In the present work, the energetics of intrinsic point defects and H-related defects in Li2O has been investigated by the first-principles method. The results show that the formation energies, charge states and relative stability of the intrinsic point defects and H-related defects in Li2O under working conditions vary with the energy level. Based on the defect properties and migration process, a model of the tritium trapping and migration mechanisms in Li2O is proposed: (1) the bred tritium is first trapped by oxygen vacancies; (2) subsequently the tritium detrapped from oxygen vacancies is retrapped by lithium vacancies, forming T substituents; and (3) the T substituents hop along the Li lattice...
February 20, 2019: Physical Chemistry Chemical Physics: PCCP
https://read.qxmd.com/read/30778922/antibacterial-effects-of-curcumin-encapsulated-in-nanoparticles-on-clinical-isolates-of-pseudomonas-aeruginosa-through-downregulation-of-efflux-pumps
#7
Saeid Rahbar Takrami, Najmeh Ranji, Majid Sadeghizadeh
Curcumin as a flavonoid from the rhizome of Curcuma longa has antibacterial, antiviral and antifungal activity. Multidrug resistance in pathogenic bacteria is continuously increasing in hospitals. The aim of this study was to investigate the effect of curcumin encapsulated in micellar/polymersome nanoparticles as an efflux pump inhibitor (EPI) on the expression of mexX and oprM genes in curcumin-treated and -untreated isolates of Pseudomonas aeruginosa. Clinical isolates of Pseudomonas aeruginosa were treated with ciprofloxacin (sub-MICs) alone and/or in combination with curcumin-encapsulated in micellar/polymersome nanoparticles...
February 18, 2019: Molecular Biology Reports
https://read.qxmd.com/read/30778887/gns561-a-new-lysosomotropic-small-molecule-for-the-treatment-of-intrahepatic-cholangiocarcinoma
#8
Sonia Brun, Firas Bassissi, Cindy Serdjebi, Marie Novello, Jennifer Tracz, François Autelitano, Marie Guillemot, Philippe Fabre, Jérôme Courcambeck, Christelle Ansaldi, Eric Raymond, Philipe Halfon
Among the acquired modifications in cancer cells, changes in lysosomal phenotype and functions are well described, making lysosomes a potential target for novel therapies. Some weak base lipophilic drugs have a particular affinity towards lysosomes, taking benefits from lysosomal trapping to exert anticancer activity. Here, we have developed a new lysosomotropic small molecule, GNS561, and assessed its activity in multiple in vitro intrahepatic cholangiocarcinoma models (HuCCT1 and RBE cell lines and patient-derived cells) and in a chicken chorioallantoic membrane xenograft model...
February 19, 2019: Investigational New Drugs
https://read.qxmd.com/read/30778714/a-dual-1-h-19-f-birdcage-coil-for-small-animals-at-7-t-mri
#9
Palmira Villa-Valverde, Ignacio Rodríguez, Daniel Padró, Marina Benito, Carlos Ernesto Garrido-Salmon, Jesús Ruiz-Cabello
OBJECTIVE: Given the growing interest in fluorine, it is necessary to develop new multi-tuned RF coils. Therefore, our objective is to design a simple and versatile double-tuned RF coil that can be used as a transmitter and receiver double-tuned coil (1 H and 19 F) or as transmitter-only double-tuned coil. MATERIALS AND METHODS: A high-pass eight-element birdcage coil was built for 1 H and 19 F for a 7 T scanner. PIN diodes and cable traps to block unwanted common mode currents in cables were introduced to confer more flexibility to the coil...
February 16, 2019: Magma
https://read.qxmd.com/read/30778485/the-3s-rydberg-state-as-a-doorway-state-in-the-ultrafast-dynamics-of-1-1-difluoroethylene
#10
Sandra Gómez, Lea M Ibele, Leticia González
The deactivation dynamics of 1,1-difluoroethylene after light excitation is studied within the surface hopping formalism in the presence of 3s and 3p Rydberg states using multi-state second order perturbation theory (MS-CASPT2). Due to the proximity of the Rydberg π-3s state with the ππ* state, the states are mixed favoring ultrafast exchange of population via a conical intersection that closely resembles the equilibrium structure. After excitation, it is found that the π-3s state acts as a doorway state, trapping the population and delaying internal conversion to the ππ* state, from which deactivation to the closed-shell ground state takes place...
February 19, 2019: Physical Chemistry Chemical Physics: PCCP
https://read.qxmd.com/read/30777111/high-fat-and-high-glucose-microenvironment-decreases-runx2-and-taz-expression-and-inhibits-bone-regeneration-in-the-mouse
#11
Xuan Wu, Yunpeng Zhang, Yixiao Xing, Bin Zhao, Cong Zhou, Yong Wen, Xin Xu
BACKGROUND: Type 2 diabetes mellitus (T2DM) and hyperlipidemia are negatively related to bone regeneration. The aim of this study was to evaluate the effect of high-fat and high-glucose microenvironment on bone regeneration and to detect the expression of runt-related transcription factor 2 (Runx2) and transcriptional co-activator with PDZ-binding domain (TAZ) during this process. METHODS: After establishing a high-fat and high-glucose mouse model, a 1 mm × 1...
February 18, 2019: Journal of Orthopaedic Surgery and Research
https://read.qxmd.com/read/30776631/numerical-modelling-of-the-suspended-particulate-matter-dynamics-in-a-regulated-river-network
#12
M Launay, V Dugué, J-B Faure, M Coquery, B Camenen, J Le Coz
Understanding and predicting the propagation, deposition and resuspension of suspended particulate matter (SPM) in river networks is important for managing water resources, ecological habitat, pollution, navigation, hydropower generation, reservoir sedimentation, etc. Observational data are scarce and costly, and there is little feedback on the efficiency of numerical simulation tools for compensating the lack of data on a river scale of several hundreds of kilometers. This paper aims at exploring the use of a one-dimensional (1-D) hydrodynamical model for understanding the source and fate of SPM during complex events...
February 10, 2019: Science of the Total Environment
https://read.qxmd.com/read/30776422/targeting-the-s1p-receptor-signaling-pathways-as-a-promising-approach-for-treatment-of-autoimmune-and-inflammatory-diseases
#13
REVIEW
Bisera Stepanovska, Andrea Huwiler
The past two decades of intense research have revealed a key role of the sphingolipid molecule sphingosine 1-phosphate (S1P) in regulating multiple physiological and pathophysiological processes including cell proliferation and survival, cell migration, inflammatory mediator synthesis and tissue remodeling. S1P mainly acts through five high-affinity G protein-coupled S1P receptors, which are ubiquitously expressed and mediate a complex network of signaling in a cell type dependent manner. S1P receptors have become an attractive pharmacological target to interfere with S1P-mediated cellular responses, which contribute to various autoimmune and inflammatory diseases...
February 15, 2019: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://read.qxmd.com/read/30776371/ameliorating-gut-microenvironment-through-staphylococcal-nuclease-mediated-intestinal-nets-degradation-for-prevention-of-type-1-diabetes-in-nod-mice
#14
Yixuan Liang, Xiaoke Wang, Dongmei He, Qi You, Tingting Zhang, Wanfa Dong, Jingjin Fei, Yun Xing, Jie Wu
AIMS: Recent studies have revealed that neutrophil extracellular traps (NETs) provide negative feedback in the progression to chronic inflammation and contribute to the pathogenesis of multiple autoimmune diseases including type 1 diabetes (T1D). In addition, accumulating evidences suggest that gut immunity play a key role in T1D pathogenesis. Our study aimed to evaluate whether staphylococcal nuclease (SNase) targeting intestinal NETs can ameliorate the intestinal inflammatory environment and protect against T1D development in non-obese diabetic(NOD) mice...
February 15, 2019: Life Sciences
https://read.qxmd.com/read/30776035/efficient-and-irreversible-capture-of-strontium-ions-from-aqueous-solution-using-metal-organic-frameworks-with-ion-trapping-groups
#15
Wanjun Mu, Shenzhen Du, Xingliang Li, Qianhong Yu, Rui Hu, Hongyuan Wei, Yuchuan Yang, Shuming Peng
Efficient and irreversible capture of radioactive nuclides is an important environmental protection task when disposing of nuclear wastewater. This paper uses an "ion trapping" concept to design an efficient adsorbent based on a metal-organic framework (MOF), for removal of radioactive strontium from nuclear wastewater. Two functionalized MOFs were achieved by the introduction of sulfate or oxalate into the pore structure of MOF-808, giving MOF-808-SO4 and MOF-808-C2O4, respectively. These functionalized MOF-808 materials exhibit excellent ability to remove Sr2+ from acidic solution due to their particular trapping action, with the maximum Sr2+ adsorption capacities of 176...
February 18, 2019: Dalton Transactions: An International Journal of Inorganic Chemistry
https://read.qxmd.com/read/30775780/aroma-profile-characterization-of-mahi-mahi-and-tuna-for-determining-spoilage-using-purge-and-trap-gas-chromatography-mass-spectrometry
#16
Jing Bai, Shirley M Baker, Renee M Goodrich-Schneider, Naim Montazeri, Paul J Sarnoski
Alcohols, aldehydes, ketones, amines, and sulfur compounds are essential aroma compounds related to fish flavor and spoilage. Gas chromatography-mass spectrometry (GC-MS) is an instrument that is widely used to identify and quantify volatile and semi-volatile compounds in fish products. In this research, a simple and accurate GC-MS method was developed to determine the aroma profile of mahi-mahi and tuna for chemical indicators of spoilage. In the developed GC-MS method, trichloroacetic acid (TCA) solution was used to extract analytes from homogenized fish samples...
February 18, 2019: Journal of Food Science
https://read.qxmd.com/read/30775368/decrease-in-population-and-increase-in-welfare-of-community-cats-in-a-twenty-three-year-trap-neuter-return-program-in-key-largo-fl-the-orcat-program
#17
Rachael E Kreisler, Heather N Cornell, Julie K Levy
The objective of this study was to evaluate the effect of a long-term (23-year) trap-neuter-return program on the population size of community cats in the Ocean Reef Community and to describe the demographic composition and outcome of enrolled cats. A retrospective study was performed using both cat census data collected between 1999 and 2013 as well as individual medical records for cats whose first visit occurred between 3/31/1995 and 12/31/2017. Medical record entries were reviewed to determine program inputs, cat outcomes, retroviral disease prevalence, and average age of first visit, sterilization, and death through 6/11/2018...
2019: Frontiers in Veterinary Science
https://read.qxmd.com/read/30774874/conformer-specific-1-2-h-tunnelling-in-captodatively-stabilized-cyanohydroxycarbene-nc-c-combining-umlaut-oh
#18
André K Eckhardt, Frederik R Erb, Peter R Schreiner
We report the gas-phase preparation of cyanohydroxycarbene by high-vacuum flash pyrolysis of ethyl 2-cyano-2-oxoacetate and subsequent trapping of the pyrolysate in an inert argon matrix at 3 K. After irradiation of the matrix with green light for a few seconds singlet trans -cyanohydroxycarbene rearranges to its cis -conformer. Prolonged irradiation leads to the formation of cyanoformaldehyde and isomeric isocyanoformaldehyde. Cis - and trans -cyanohydroxycarbene were characterized by matching matrix IR and UV/Vis spectroscopic data with ab initio coupled cluster and TD-DFT computations...
January 21, 2019: Chemical Science
https://read.qxmd.com/read/30774773/prostate-specific-loss-of-uxt-promotes-cancer-progression
#19
Yu Wang, Eric D Schafler, Phillip A Thomas, Susan Ha, Gregory David, Emily Adney, Michael J Garabedian, Peng Lee, Susan K Logan
Ubiquitously-expressed, prefoldin-like chaperone (UXT) also called Androgen Receptor Trapped clone-27 (ART-27) is widely expressed in human tissues. Our previous studies showed that UXT regulates transcription repression including androgen receptor (AR) signaling in prostate cancer. Here we analyzed a tissue microarray consisting of normal prostate, benign prostatic hyperplasia, high grade prostatic intraepithelial neoplasia (HGPIN) and primary prostate cancer cases for UXT protein expression. We found that HGPIN and malignant tumors have significantly decreased UXT expression compared to the normal prostate...
January 22, 2019: Oncotarget
https://read.qxmd.com/read/30774745/charge-mobility-and-recombination-mechanisms-in-tellurium-van-der-waals-solid
#20
Prashant Bhaskar, Alexander W Achtstein, Martien J W Vermeulen, Laurens D A Siebbeles
Trigonal tellurium is a small band gap elemental semiconductor consisting of van der Waals bound one-dimensional helical chains of tellurium atoms. We study the temperature dependence of the charge carrier mobility and recombination pathways in bulk tellurium. Electrons and holes are generated by irradiation of the sample with 3 MeV electrons and detected by time-resolved microwave conductivity measurements. A theoretical model is used to explain the experimental observations for different charge densities and temperatures...
January 10, 2019: Journal of Physical Chemistry. C, Nanomaterials and Interfaces
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