Suyuan Zhang, Bin Yang, Xiaoting Shen, Hong Chen, Fulin Wang, Zhipeng Tan, Wangsheng Ou, Cuifeng Yang, Congyuan Liu, Hao Peng, Peng Luo, Limei Peng, Zhenmin Lei, Sunxing Yan, Tao Wang, Qiong Ke, Chunhua Deng, Andy Peng Xiang, Kai Xia
Leydig cell failure (LCF) caused by gene mutations leads to testosterone deficiency, infertility and reduced physical function. Adeno-associated virus serotype 8 (AAV8)-mediated gene therapy shows potential in treating LCF in the Lhcgr-deficient (Lhcgr-/- ) mouse model. However, the gene-treated mice still cannot naturally sire offspring, indicating the modestly restored testosterone and spermatogenesis in AAV8-treated mice remain insufficient to support natural fertility. Recognizing this, we propose that enhancing gene delivery could yield superior results...
May 30, 2024: Cell Proliferation