Lubaina Ehsan, David Coomes, Paul Kelly, Adam R Greene, S Asad Ali, Chola Mulenga, Donna M Denno, Kelley VanBuskirk, Muhammad Faraz Raghib, Mustafa Mahfuz, Sean R Moore, M Shabab Hossain, Tahmeed Ahmed, Peter B Sullivan, Christopher A Moskaluk, Sana Syed
BACKGROUND: Environmental enteric dysfunction (EED), a chronic inflammatory condition of the small intestine, is an important driver of childhood malnutrition globally. Quantifying intestinal morphology in EED allows for exploration of its association with functional and disease outcomes. OBJECTIVE: We sought to define morphometric characteristics of childhood EED and determine whether morphology features were associated with disease pathophysiology. METHODS: Morphometric measurements and histology were assessed on duodenal biopsy slides for this cross-sectional study from children with EED in Bangladesh, Pakistan, and Zambia (n=69), and those with no pathologic abnormality (NPA; n=8) or celiac disease (n=18) in North America...
April 27, 2024: American Journal of Clinical Nutrition