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JOURNAL ARTICLE
Yinsong Xu, Yuanzhi Li
BACKGROUND: Several observational studies suggest a possible link between lipid-lowering drugs and allergic diseases. However, inferring causality from these studies can be challenging due to issues such as bias, reverse causation, and residual confounding. To investigate the potential causal effect of lipid-lowering drugs, proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors and 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase (HMGCR) inhibitors, on allergic diseases (allergic asthma, allergic conjunctivitis, atopic dermatitis, allergic rhinitis, and allergic urticaria), we performed a Mendelian randomization (MR)-based study...
April 2024: World Allergy Organization Journal
#2
JOURNAL ARTICLE
Sally Khalil, Sherin Rahim, Hassan Mobayed, Maryam Al-Nesf
BACKGROUND: Patch testing is the primary diagnostic approach for contact dermatitis,1 an inflammatory skin reaction caused by exposure to external irritants. The pathophysiology of contact dermatitis may entail an immunological response (hypersensitivity type IV), a non-immunological response (irritant contact dermatitis), or a mix of the two. The diagnosis of contact dermatitis requires a correlation between a positive patch test and clinical relevance.2 This study aims to determine the prevalence of allergy sensitization among adults in Qatar and the allergens most frequently associated with positive patch test findings...
2023: Qatar Medical Journal
#3
JOURNAL ARTICLE
Sherin Thalappil, Tayseer Ibrahim, Sibi Shibu, Hassan Mobayed, Maryam Al-Nesf
BACKGROUND: Allergic respiratory diseases (allergic rhinitis and asthma) are major health problems with high prevalence causing significant patient morbidity as well as an economic burden (1). Sensitization to inhaled allergens is a major factor in the pathogenesis of allergic respiratory diseases (2). This study aims to determine the commonest aeroallergen sensitization in patients with allergic symptoms who attended an Adult Allergy Clinic in Qatar. METHODS: This retrospective study reviewed the skin prick test results database of 20 aeroallergens performed between January 1st to December 31st , 2022, at an Adult Allergy clinic in Qatar...
2023: Qatar Medical Journal
#4
JOURNAL ARTICLE
Chunjiao Zheng, Ying Zou
INTRODUCTION: Allergen distribution has obvious geographical characteristics. Understanding local epidemiological data may provide evidence-based strategies for the prevention and management of disease. We investigated the distribution of allergen sensitization in patients with skin diseases in Shanghai, China. METHODS: Data from tests for serum-specific immunoglobulin E were collected from 714 patients with three skin diseases who visited the Shanghai Skin Disease Hospital from January 2020 to February 2022...
2023: Journal of Asthma and Allergy
#5
JOURNAL ARTICLE
Hilal Ünsal, Sevda Tüten Dal, Ayşegül Akarsu, Ümit Murat Şahiner, Özge Soyer, Bülent Enis Şekerel
BACKGROUND: Optimum management of food allergy (FA) includes consideration of co-allergies and multimorbidities and tolerance assessment. Documentation of FA practices may pave the way for better practice. METHODS: Patients aged 3-18 years, with persistent IgE-mediated hen`s egg allergy were reviewed. RESULTS: A total of 102 children with a median age of 59 months (IQR= 40-84) (72.2% males) were included. All were diagnosed during infancy and the initial symptoms were atopic dermatitis (65...
2023: Turkish Journal of Pediatrics
#6
JOURNAL ARTICLE
Xue-Jiao Qian, Xiao-Tian Hu, Ping Jiang
OBJECTIVE: The present study aims to evaluate the efficacy of an anti-immunoglobulin E monoclonal antibody (omalizumab) in the treatment of allergic asthma (AS). METHODS: A total of 34 patients with moderate-to-severe bronchial asthma admitted to the Respiratory Department of Tianjin First Central Hospital between September 2019 and September 2021 were enrolled in this study. The patients were treated with omalizumab in addition to conventional inhaled corticosteroids + long-acting β2 agonist treatment...
November 24, 2022: Immunology
#7
REVIEW
Priyanga Suriyamoorthy, Alluru Madhuri, Srikanth Tangirala, Karunai Raj Michael, Vignesh Sivanandham, Ashish Rawson, Arunkumar Anandharaj
The pulp of the banana fruit is rich in bioactive compounds like dietary fibers, low glycemic carbohydrates, natural sugars, vitamins, minerals and antioxidants. These beneficial compounds are responsible for the proper functioning of immune system and enhance prevention against various deadly diseases like cancer, diabetes and heart diseases. Despite having, positive effects, the fruit are recognized as an important source for causing allergy to 0.6% of people in general population and up to 67 and 46% for people with asthma or atopic dermatitis...
June 2022: Plant Foods for Human Nutrition
#8
JOURNAL ARTICLE
Eustachio Nettis, Luisa Brussino, Vincenzo Patella, Laura Bonzano, Aikaterini Detoraki, Elisabetta Di Leo, Maria Maddalena Sirufo, Cristiano Caruso, Fabio Lodi Rizzini, Mariaelisabetta Conte, Mona-Rita Yacoub, Massimo Triggiani, Erminia Ridolo, Luigi Macchia, Giovanni Rolla, Raffaele Brancaccio, Amato De Paulis, Giuseppe Spadaro, Danilo Di Bona, Angela Maria D'Uggento, Lia Ginaldi, Francesco Gaeta, Eleonora Nucera, Kliljeda Jaubashi, Danilo Villalta, Lorenzo Dagna, Domenico Ciotta, Francesco Pucciarini, Diego Bagnasco, Giorgio Celi, Fulvia Chieco Bianchi, Lorenzo Cosmi, Maria Teresa Costantino, Maria Angiola Crivellaro, Simona D'Alò, Pietro Del Biondo, Stefano Del Giacco, Mario Di Gioacchino, Linda Di Pietro, Elisabetta Favero, Sebastiano Gangemi, Gabriella Guarnieri, Enrico Heffler, Maria Stefania Leto Barone, Carla Lombardo, Francesca Losa, Andrea Matucci, Paola Lucia Minciullo, Paola Parronchi, Giovanni Passalacqua, Stefano Pucci, Oliviero Rossi, Lorenzo Salvati, Michele Schiappoli, Gianenrico Senna, Andrea Vianello, Alessandra Vultaggio, Yang Baoran, Cristoforo Incorvaia, Giorgio Walter Canonica
BACKGROUND: Biologics are currently one of the main treatment options for a number of diseases. The IgG4 monoclonal antibody dupilumab targets the Interleukin-4 receptor alpha chain, thus preventing the biological effects of the cytokines IL-4 and IL-13, that are essential for the Th2 response. Several controlled trials showed that dupilumab is effective and safe in patients with atopic dermatitis (AD), severe asthma and chronic rhinosinusitis with nasal polyps (CRSwNP), thus resulting in approval by regulatory agencies...
May 19, 2022: Clinical and Molecular Allergy: CMA
#9
REVIEW
Albert C Chong, Won Jong Chwa, Peck Y Ong
PURPOSE OF REVIEW: While aeroallergens are a well-established trigger of asthma and allergic rhinitis, their role in allergic skin diseases such as atopic dermatitis and chronic urticaria remains controversial. This paper reviews the pathophysiology and clinical evidence for aeroallergens in these allergic skin diseases and summarizes current strategies for evaluation and management. RECENT FINDINGS: Current evidence implicates aeroallergens as triggers of cutaneous reactions in atopic dermatitis...
July 2022: Current Allergy and Asthma Reports
#10
JOURNAL ARTICLE
Saad Alhumaid, Abbas Al Mutair, Zainab Al Alawi, Ali A Rabaan, Raghavendra Tirupathi, Mohammed A Alomari, Aqeel S Alshakhes, Abeer M Alshawi, Gasmelseed Y Ahmed, Hassan M Almusabeh, Tariq T Alghareeb, Abdulaziz A Alghuwainem, Zainab A Alsulaiman, Mohammed A Alabdulmuhsin, Emad A AlBuwaidi, Amjad K Bu Dukhi, Hani N Mufti, Manaf Al-Qahtani, Kuldeep Dhama, Jaffar A Al-Tawfiq, Awad Al-Omari
BACKGROUND: Currently there is no systematic review and meta-analysis of the global incidence rates of anaphylactic and nonanaphylactic reactions to SARS-CoV-2 vaccines in the general adult population. OBJECTIVES: To estimate the incidence rates of anaphylactic and nonanaphylactic reactions after COVID-19 vaccines and describe the demographic and clinical characteristics, triggers, presenting signs and symptoms, treatment and clinical course of confirmed cases. DESIGN: A systematic review and meta-analysis...
October 16, 2021: Allergy, Asthma, and Clinical Immunology
#11
JOURNAL ARTICLE
Jonathan Bar, Sari Godlewicz, Arieh Ingber, Eli Sprecher, Dan Slodownik
BACKGROUND: Chronic spontaneous urticaria (CSU) is a common debilitating condition. Although not completely understood, the main pathomechanism involves autoimmune-related mast-cell degranulation. Patch test (PT) is the gold standard for the diagnosis of type IV cutaneous hypersensitivity. The relevance of PT to the diagnosis of CSU is debatable. OBJECTIVE: We aimed at determining the role of PT in selected patients with CSU. METHODS: In this retrospective study, we reviewed cases of patients referred for patch testing at our clinic...
2021: Journal of Asthma and Allergy
#12
JOURNAL ARTICLE
Oner Ozdemir
OBJECTIVE: When applied by well-trained personnel, skin prick test (SPT) for a variety of inhalant and/or food allergens is a safe procedure although it may rarely cause systemic reaction. In this article, our aim was to evaluate the reactions after SPTs for the past 6 years in Turkish children having various allergic symptoms brought to our clinic. METHODS: The results of the SPTs, performed between May 2013 and March 2019, of 12.529 patients whose ages vary from 2 months to 18 years have been retrospectively evaluated...
2021: Northern Clinics of Istanbul
#13
Takae Kobayashi, Masashi Nakamura, Kayoko Matsunaga, Joon Nakata, Kazunori Tagami, Nayu Sato, Takashi Kawabe, Yasuto Kondo
An 8-year-old boy with poor control of atopic dermatitis could eat potato products such as French fries without restrictions until 21 months of age. However, he developed generalized urticaria after eating potato products at the same age. Therefore, potatoes were excluded from his diet; nevertheless, he continued to consume a very small amount of potato starch but was without symptoms until the age of 8 years. At this age, he developed anaphylaxis after consuming potato starch and required administration of intramuscular epinephrine...
April 2021: Asia Pacific Allergy
#14
Yasuhiro Haneda, Saori Kadowaki, Midori Furui, Takeshi Taketani
Food-dependent exercise-induced anaphylaxis (FDEIA) caused by fruits and vegetables is increasing in recent years, but rice-induced FDEIA is rarely reported. The mechanism of FDEIA is unclear, although percutaneous sensitization occurs in some cases. A 14-year-old adolescent came our hospital who had 6 episodes of unknown FDEIA occurring from age 13. He affected atopic dermatitis in infancy, and he had been polishing rice daily to help with housework, and also had occasionally begun to observe urticaria while bathing after eating rice from 5 years old...
January 2021: Asia Pacific Allergy
#15
JOURNAL ARTICLE
Satoshi Hirase, Naoko Takeo, Masashi Nakamura, Nayu Sato, Kayoko Matsunaga, Hiroaki Taniguchi, Kunitaka Ota
BACKGROUND: Cochineal dyes are used as additives in various foods for the purpose of red coloration. On the other hand, although it has been reported as a causative agent of immediate allergy, most of them are adult women. We report a case of an 8-year-old boy who developed a cochineal allergy.Current disease history: He has been suffering from atopic dermatitis, bronchial asthma, and food allergies since childhood. At the age of seven, he experienced an unknown anaphylaxis reaction twice...
2020: Arerugī, [Allergy]
#16
JOURNAL ARTICLE
Yossi Rosman, Alon Y Hershko, Keren Meir-Shafrir, Ron Kedem, Idit Lachover-Roth, Yoseph A Mekori, Ronit Confino-Cohen
BACKGROUND: Although chronic spontaneous urticaria (CSU) affects all age groups, data regarding CSU in adolescents is scarce. OBJECTIVE: To characterize the epidemiology, demographics, and comorbidities associated with CSU in a large, cross-sectional nationwide population of adolescents. METHODS: Medical records of 16-year-old candidate conscripts to the Israeli Defense Forces were reviewed. Data were collected on the prevalence and severity of CSU, as well as the demographics, medical comorbidities, medication use, and blood test results of affected individuals...
July 2019: Journal of the American Academy of Dermatology
#17
JOURNAL ARTICLE
Beáta Hutyrová, Jaromír Bystroň
Introduction: Omalizumab is indicated for the treatment of severe allergic asthma (SAA) and chronic spontaneous urticaria, although a number of studies have confirmed the effectiveness of this therapy also for other IgE-mediated diseases. Aim: To assess the impact of anti-IgE therapy on SAA and comorbid IgE-mediated allergic diseases in patients treated with omalizumab for SAA enrolled in the CAR (Czech Anti-IgE Registry). Material and methods: Three hundred and ten patients with SAA treated with omalizumab were enrolled in the CAR...
October 2018: Postȩpy Dermatologii i Alergologii
#18
JOURNAL ARTICLE
Selçuk Yazıcı, Soner Güneş, Melike Kurtuluş-Çokboz, Özlem Kemer, Gülce Baranlı, Sezin Aşık-Akman, Demet Can
Yazıcı S, Güneş S, Kurtuluş-Çokboz M, Kemer Ö, Baranlı G, Aşık-Akman S, Can D. Allergen variability and house dust mite sensitivity in pre-school children with allergic complaints. Turk J Pediatr 2018; 60: 41-49. The increase in the prevalence of allergic diseases in pre-school children who are often at home may be due to an increase in house dust mite sensitivity, which is rarely expected in this age group. In our study, it was aimed to investigate allergen sensitivities, especially house dust mite sensitivity in pre-school children with allergic disease complaints by skin prick test (SPT)...
2018: Turkish Journal of Pediatrics
#19
JOURNAL ARTICLE
Supa Oncham, Umaporn Udomsubpayakul, Wannada Laisuan
BACKGROUND: The global prevalence of allergic rhinitis, asthma, and atopic dermatitis has risen significantly over the last 2 decades. Allergic sensitization to aeroallergen is a major risk factor in developing the allergic disease. The prevalence of aeroallergen sensitization varies in different regions and countries. OBJECTIVE: To determine the prevalence of common aeroallergen sensitization and the atopic status among adult patients. METHODS: A cross-sectional, retrospective study...
April 2018: Asia Pacific Allergy
#20
JOURNAL ARTICLE
Chih-Hung Lee, Chia-Ching Wu, Yu-Chang Tyan, Wei-Tai Yu, Edward S Huang, Hsu-Sheng Yu
Food allergy is one of the most important health issues worldwide. In Taiwan, current literature suggests shrimps and crabs are the most common causes of food allergy, and are frequently associated with acute allergic reactions such as urticaria, atopic dermatitis, and asthma. However, knowledge regarding the shrimp allergens remains limited. Thus, there is an urgent need to establish comprehensive information for elucidating underlying triggers for food allergy. In this study, whiteleg shrimp (Litopenaeus vannamei) was used to evaluate the IgE-binding properties of various shrimp proteins to 7 allergic patients' sera by western blot...
August 30, 2018: Food Chemistry
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