Susumu Suzuki, Jianwei Liu, Yuri Sato, Rikuto Miyake, Souma Suzuki, Yoko Okitsu, Tomohiko Fukuda, Tomoya Isaji, Jianguo Gu, Shinichiro Takahashi
For acute promyelocytic leukemia (APL), differentiation therapy with all-trans retinoic acid (ATRA) is well established. However, the narrow application and tolerance development of ATRA remain to be improved. In this study, we investigated the effects of combinations of glycosylation inhibitors with ATRA to achieve better efficiency than ATRA alone. We found that the combination of fucosylation inhibitor 6-alkynylfucose (6AF) and ATRA had an additional effect on cell differentiation, as revealed by expression changes in two differentiation markers, CD11b and CD11c, and significant morphological changes in NB4 APL and HL-60 acute myeloid leukemia (AML) cells...
January 29, 2024: Biochemical and Biophysical Research Communications