Qiang Liu, Liyun Zheng, Yue Wang, Zhicheng Huang, Jianpeng Zhu, Mengdie Fang, Lu Xie, Cong Ding, Ye Gu, Dongchao Xu, Hangbin Jin, Jianfeng Yang, Xiaofeng Zhang, Hongzhang Shen
AIMS: Primary choledocholithiasis is a common digestive disease with high morbidity and relapse. However, the compositions and functions of the bile microbial ecosystem and the pathogenesis of microfloral regulation of host metabolism resulting in stone formation are poorly understood. MAIN METHODS: Biliary samples collected from patients with acute cholangitis induced by benign biliary stricture (nonlithiasis group, n = 17) and primary choledocholithiasis (lithiasis group, n = 33) were subjected to multiomics analyses...
October 15, 2023: Life Sciences