Enni Chen, Jiawei Wu, Jiajia Huang, Wancui Zhu, Haohui Sun, Xiaonan Wang, Dagui Lin, Xiaodi Li, Dingbo Shi, Zhiqiao Liu, Jinsheng Huang, Miao Chen, Fangyun Xie, Wuguo Deng
Nasopharyngeal carcinoma (NPC)-mediated immunosuppression within the tumor microenvironment (TME) frequently culminates in the failure of otherwise promising immunotherapies. In this study, we identify tumor-intrinsic FLI1 as a critical mediator in impairing T cell anti-tumor immunity. A mechanistic inquiry reveals that FLI1 orchestrates the expression of CBP and STAT1, facilitating chromatin accessibility and transcriptional activation of IDO1 in response to T cell-released IFN-γ. This regulatory cascade ultimately leads to augmented IDO1 expression, resulting in heightened synthesis of kynurenine (Kyn) in tumor cells...
May 30, 2024: Nature Communications