Carole Le Coz, Melissa Trofa, Dorothy L Butler, Samuel Yoon, Tian Tian, Whitney Reid, Emylette Cruz Cabrera, Ainsley V C Knox, Caroline Khanna, Kathleen E Sullivan, Jennifer Heimall, Patricia Takach, Olajumoke O Fadugba, Monica Lawrence, Soma Jyonouchi, Hakon Hakonarson, Andrew D Wells, Steven Handler, Karen B Zur, Vinodh Pillai, Jeffrey C Gildersleeve, Neil Romberg
BACKGROUND: Autoantibody-mediated cytopenias (AICs) regularly occur in profoundly IgG-deficient common variable immunodeficiency (CVID) patients. The isotypes, antigenic targets, and origin(s) of their disease-causing autoantibodies are unclear. OBJECTIVE: To determine reactivity, clonality and provenance of AIC-associated IgM autoantibodies in CVID patients. METHODS: We utilized glycan arrays, patient erythrocytes, and platelets to determine targets of CVID IgM autoantibodies...
April 29, 2024: Journal of Allergy and Clinical Immunology