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linear iga bullous dermatosis | Page 2

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https://read.qxmd.com/read/31110752/vancomycin-induced-linear-iga-bullous-dermatosis-labd-an-atypical-presentation
#21
Lorena Visentainer, Juliana Yumi Massuda, Maria Letícia Cintra, Renata Ferreira Magalhães
We report an uncommon presentation of bullous dermatosis by linear IgA. There are few cases reported in the literature with this form of presentation starting with mucosal lesions and then evolving into a similar bullous pemphigoid pattern. In addition, we emphasize the importance of direct immunofluorescence for the definitive diagnosis.
May 2019: Clinical Case Reports
https://read.qxmd.com/read/31014539/linear-iga-bullous-dermatosis-a-series-of-17-cases
#22
M S Díaz, L Morita, B Ferrari, S Sartori, M F Greco, L Sobrevias Bonells, M A González-Enseñat, M A Vicente Villa, M Larralde
Linear IgA bullous dermatosis is an acquired subepidermal immunoglobulin-mediated vesiculobullous disease. In this retrospective, observational, descriptive study, we describe the clinical characteristics, treatments, and outcomes of 17 patients with linear IgA bullous dermatosis. Two children had been vaccinated 2 weeks before the onset of symptoms, 2 had had bronco-obstructive respiratory symptoms, and 1 had received intravenous antibiotic therapy. We also observed an association with autoimmune hepatitis in one patient and alopecia areata in another...
April 20, 2019: Actas Dermo-sifiliográficas
https://read.qxmd.com/read/31001428/bullous-dermatosis-suspected-in-an-8-month-old-child-in-guinea-bissau
#23
Beatriz Valle Del Barrio, Danila Luraschi, Robert Micheletti, Laurent Hiffler, Ana Paula Arias
An 8-month-old child was admitted to a paediatric intensive care unit in Guinea-Bissau with severe blistering dermatosis. He was treated with broad spectrum antibiotics and dressings, without improvement. After 2 weeks, linear IgA bullous dermatosis was suspected. Owing to lack of dapsone, the child was treated with prednisolone and improved. To avoid corticosteroids side effects, 2 months after starting prednisolone we switched to colchicine, but the boy's condition worsened for reasons of poor adherence, requiring intravenous corticosteroids and antibiotics...
April 2019: Oxford Medical Case Reports
https://read.qxmd.com/read/30973330/erythrodermic-linear-iga-igg-bullous-dermatosis
#24
Takanao Matsumoto, Satoshi Nakamura, Norito Ishii, Naoka Umemoto, Masaaki Kawase, Toshio Demitsu, Takashi Hashimoto
No abstract text is available yet for this article.
April 10, 2019: European Journal of Dermatology: EJD
https://read.qxmd.com/read/30900757/clinical-pathologic-and-immunologic-features-of-pemphigus-herpetiformis-a-literature-review-and-proposed-diagnostic-criteria
#25
REVIEW
Lorena M C Costa, Mark A Cappel, James H Keeling
Pemphigus herpetiformis (PH), a rare type of pemphigus, is characterized by immunologic findings consistent with pemphigus but with a unique clinical and pathologic presentation. PH was first described as resembling dermatitis herpetiformis clinically, but because of its variable presentation, it can also resemble linear immunoglobulin A bullous dermatosis and bullous pemphigoid. We reviewed reported cases to analyze the most frequent clinical, pathologic, and immunologic characteristics and to propose corresponding diagnostic criteria...
September 2019: International Journal of Dermatology
https://read.qxmd.com/read/30874843/-linear-iga-bullous-dermatosis
#26
REVIEW
H A Juratli, M Sárdy
Linear IgA bullous dermatosis is a rare autoimmune blistering disease that occurs in both children and adults. Strings of pearls, crowns of jewels, rosettes and urticarial plaques can occur on the whole integument with emphasis on the face (particularly perioral area) and genitalia. Pruritus is common and may be severe. The presence of IgA deposits along the basement membrane can usually be identified using direct immunofluorescence (DIF) microscopy. The histological and clinical features of this disorder may mimic those of dermatitis herpetiformis...
March 15, 2019: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://read.qxmd.com/read/30847379/linear-iga-bullous-dermatosis-protracted-by-vancomycin-loaded-bone-cement
#27
Nathan Nartker, Natalie Kudlak, David Crowe
No abstract text is available yet for this article.
March 2019: JAAD Case Reports
https://read.qxmd.com/read/30809685/drug-induced-linear-iga-bullous-dermatosis-a-case-report-and-review-of-the-literature
#28
Judith Lammer, Rüdiger Hein, Sophie Roenneberg, Tilo Biedermann, Thomas Volz
Linear IgA bullous dermatosis (LABD) is a rare subepidermal autoimmune blistering disease characterized by linear deposition of IgA along the basement membrane zone. Although most reported cases are idiopathic, there is a subset of patients with drug-induced LABD. Various drugs have been associated with the drug-induced form of the disease. This paper reviews the literature on drugs reported to elicit linear IgA dermatosis and its specific clinical presentation. In addition, a case report of a 77-year-old male patient with linear IgA dermatosis induced by vancomycin is described...
February 27, 2019: Acta Dermato-venereologica
https://read.qxmd.com/read/30702174/long-term-evolving-profile-of-childhood-autoimmune-blistering-diseases-retrospective-study-on-38-children
#29
A Welfringer-Morin, L Bekel, N Bellon, A Gantzer, O Boccara, S Hadj-Rabia, S Leclerc-Mercier, A Frassati-Biaggi, S Fraitag, C Bodemer
BACKGROUND: Autoimmune bullous dermatoses (AIBDs) in children are uncommon, and their long-term evolution remains unknown. OBJECTIVE: The aim of this retrospective study was to characterize the long-term prognosis of AIBDs that started during childhood. METHODS: We conducted a monocentric retrospective study, in the French dermatology centre, by including all children affected by AIBDs. The long-term outcome was obtained through a phone call questionnaire...
June 2019: Journal of the European Academy of Dermatology and Venereology: JEADV
https://read.qxmd.com/read/30671527/linear-iga-bullous-dermatosis-treated-with-rituximab
#30
Camille Pinard, Vivien Hebert, Myriam Lecuyer, Laurine Sacre, Pascal Joly
No abstract text is available yet for this article.
February 2019: JAAD Case Reports
https://read.qxmd.com/read/30647502/systemic-lupus-erythematosus-with-linear-iga-bullous-dermatosis-and-renal-vascular-lesions-an-extremely-rare-association
#31
R Malipatel, V Gnanapriya, A Manocha, Y K Inchara
We report a rare case of systemic lupus erythematosus presenting initially with cutaneous manifestations of linear IgA bullous dermatosis. Later the patient developed renal abnormalities due to thrombotic microangiopathy and lupus nephritis with inflammatory necrotizing vasculitis. Paucity of immune deposits was observed on Immunofluorescence. This association of SLE with these cutaneous and renal lesions is rarely reported in the literature.
November 2018: Indian Journal of Nephrology
https://read.qxmd.com/read/30511379/drug-induced-linear-immunoglobulin-a-bullous-dermatosis-a-french-retrospective-pharmacovigilance-study-of-69-cases
#32
Bethsabée Garel, Saskia Ingen-Housz-Oro, Daniele Afriat, Catherine Prost-Squarcioni, Florence Tétart, Benoit Bensaid, Corina Bara Passot, Marie Beylot-Barry, Vincent Descamps, Sophie Duvert-Lehembre, Sabine Grootenboer-Mignot, Géraldine Jeudy, Angèle Soria, Marie Blanche Valnet-Rabier, Annick Barbaud, Frédéric Caux, Bénédicte Lebrun-Vignes
AIMS: Linear immunoglobin A (IgA) bullous dermatosis is a rare autoimmune dermatosis considered spontaneous or drug-induced (DILAD). We assessed all DILAD cases, determined the imputability score of drugs and highlighted suspected drugs. METHODS: Data for patients with DILAD were collected retrospectively from the French Pharmacovigilance network (from 1985 to 2017) and from physicians involved in the Bullous Diseases French Study Group and the French Investigators for Skin Adverse Reactions to Drugs...
March 2019: British Journal of Clinical Pharmacology
https://read.qxmd.com/read/30461424/linear-iga-bullous-dermatosis-preceding-the-diagnosis-of-primary-sclerosing-cholangitis-and-ulcerative-colitis-a-case-report
#33
Victoria S Humphrey, Jonathan J Lee, Teerawit Supakorndej, Shahid M Malik, Arthur C Huen, Jedrych Jaroslaw
Linear IgA bullous dermatosis (LABD) is a rare autoimmune blistering disorder seen in the pediatric and adult populations that is often linked to a medication, infection, or underlying gastrointestinal, hepatobiliary, or autoimmune disease. In this study, we describe the case of a 23-year-old white man whose presentation and diagnosis of LABD ultimately led to the discovery of underlying primary sclerosing cholangitis (PSC) and ulcerative colitis (UC). His dermatitis resolved with topical steroids and dapsone, and he is undergoing systemic treatment for his UC and PSC...
November 15, 2018: American Journal of Dermatopathology
https://read.qxmd.com/read/30460586/-decoratively-figured-blisters-on-the-whole-integument-in-initially-diagnosed-ulcerative-colitis
#34
Wolfgang Konschake, Georg Daeschlein, Michael Jünger, Stine Lutze
The rare case of a 61-year-old patient suffering from linear IgA dermatosis is presented. The patient was previously hospitalized with chronic inflammatory bowel disease. The correct diagnosis of the disease was based on clinical and histological findings. Serological methods, such as indirect immunofluorescence, ELISA and immunoblotting are suitable for identification of the autoantibodies. In this case the detection of IgA antibodies along the basal membrane was achieved by direct immunofluorescence. Other bullous dermatoses with similar symptoms, such as an IgG-mediated bullous pemphigoid have to be excluded...
November 20, 2018: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://read.qxmd.com/read/30261573/linear-iga-bullous-dermatosis-associated-with-ulcerative-proctitis-treatment-challenge
#35
Tatyana Yetto, Carrick Burns
Linear IgA bullous dermatosis is a rare bullous disease in children and adults that can be associated with autoimmune conditions, malignancies, infections, or medication exposure. The definitive diagnosis relies on the biopsy. A 58-year-old man presented to our clinic with a pruritic vesicular and bullous eruption. Histology showed the classic findings of a subepidermal blister with neutrophilic infiltrate and linear IgA deposition along the dermal-epidermal junction. Upon further evaluation, he was diagnosed with ulcerative proctitis...
July 15, 2018: Dermatology Online Journal
https://read.qxmd.com/read/30184311/non-infectious-diffuse-vesiculobullous-rash-in-a-pancreas-and-renal-transplant-recipient
#36
Anthony Rainey, Jena Auerbach, Kairav Shah
Solid organ transplant patients are well established to be at risk of herpes simplex virus and varicella zoster virus infection and reactivation. We present a case of a 41-year-old woman with a history of pancreas and renal transplant who presented with what appeared to be disseminated herpes simplex virus or varicella zoster virus induced rash, but who was ultimately diagnosed and treated as linear IgA bullous dermatosis. This case alerts physicians to other non-infectious dermatoses as a cause of vesiculobullous rash in solid organ transplant patients...
December 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://read.qxmd.com/read/30142738/diffuse-vesiculobullous-eruption-with-systemic-findings
#37
Kenneth J Helmandollar, Kara R Hoverson, Rachel C Falkner, Jon H Meyerle
Drug induced linear IgA bullous dermatosis (LABD) is a rare blistering disease that has been shown to be associated with the use of various medications. Although rarely seen together, some of the medications associated with LABD can lead to the syndrome drug reaction with eosinophilia and systemic symptoms (DRESS), which presents with fever, cutaneous eruption, and multi-organ involvement. We present a patient who developed fever and a generalized vesiculobullous eruption after recently starting amlodipine and meloxicam...
May 15, 2018: Dermatology Online Journal
https://read.qxmd.com/read/30025829/bullous-disorders-associated-with-anti-pd-1-and-anti-pd-l1-therapy-a-retrospective-analysis-evaluating-the-clinical-and-histopathologic-features-frequency-and-impact-on-cancer-therapy
#38
Jacob Siegel, Mariam Totonchy, William Damsky, Juliana Berk-Krauss, Frank Castiglione, Mario Sznol, Daniel P Petrylak, Neal Fischbach, Sarah B Goldberg, Roy H Decker, Angeliki M Stamatouli, Navid Hafez, Earl J Glusac, Mary M Tomayko, Jonathan S Leventhal
BACKGROUND: Bullous disorders associated with anti-programmed cell death 1 (PD-1)/programmed cell death ligand 1 (PD-L1) therapy are increasingly reported and may pose distinct therapeutic challenges. Their frequency and impact on cancer therapy are not well established. OBJECTIVE: To evaluate the clinical and histopathologic findings, frequency, and impact on cancer therapy of bullous eruptions due to anti-PD-1/PD-L1 therapy. METHODS: We retrospectively reviewed the medical records of patients evaluated by the oncodermatology clinic and consultative service of Yale New Haven Hospital from 2016 to 2018...
December 2018: Journal of the American Academy of Dermatology
https://read.qxmd.com/read/29989869/the-value-of-type-iv-collagen-immunohistochemical-staining-in-the-differential-diagnosis-of-autoimmune-subepidermal-bullous-diseases
#39
Ho Yeol Lee, Seung Pil Ham, Yoo Won Choi, Hai-Jin Park
Autoimmune subepidermal bullous diseases (AISBDs) exhibit various clinical presentations, histological appearances, prognoses, and responses to treatment. Many diagnostic techniques, such as direct immunofluorescence (IF), indirect salt-split skin IF, and enzyme-linked immunosorbent assays, are used in the differential diagnoses of AISBDs. However, these techniques require fresh frozen tissue, expensive laboratory equipment, and sophisticated laboratory techniques. The purpose of this study was to evaluate the value of type IV collagen immunohistochemical (IHC) staining for the differential diagnosis of AISBDs...
June 2018: Acta Dermatovenerologica Croatica: ADC
https://read.qxmd.com/read/29924252/adult-linear-iga-bullous-dermatosis-report-of-three-cases
#40
Taila Yuri Siqueira Machado, Milvia Maria Simões E Silva Enokihara, Tatiana Miyuki Iida, Adriana Maria Porro
Linear immunoglobulin A bullous dermatosis is a rare autoimmune disease that usually has an excellent prognosis in childhood; however, its control is more difficult in adults. It presents heterogeneous clinical manifestations and is frequently confused with other bullous diseases such as bullous pemphigoid and Duhring's dermatitis herpetiformis. Dermatologists' awareness of this disease contributes to early diagnosis and appropriate treatment. We thus report three cases of linear immunoglobulin A dermatosis in adults...
June 2018: Anais Brasileiros de Dermatologia
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