Dimitra Koumaki, Vasiliki Koumaki, Sotirios Boumpoucheropoulos, Alexander Katoulis, Charikleia Kouvidou, Maria Stefanidou, Panagiotis P Bitados, Ludmila Baltaga, Orestis Miaris, George Evangelou, Sabine Elke Krueger-Krasagakis, Konstantinos Krasagakis
We report a case of linear IgA bullous dermatosis, a rare autoimmune blistering disorder that usually presents with the abrupt onset of tense bullae. We also emphasize the importance of direct immunofluorescence for the definitive diagnosis.
July 2020: Clinical Case Reports
Sofia Raiber, Tanya Sezin, Christian D Sadik, Reuven Bergman, Emily Avitan-Hersh
Neonatal autoimmune subepidermal blistering disease is rare. Mucosal involvement is more common in neonatal linear immunoglobulin A (IgA) bullous dermatosis. We describe a neonate with subepidermal cutaneous blistering disease with severe laryngeal and esophageal involvement leading to acute respiratory distress. Histopathology demonstrated a subepidermal blister with neutrophils and eosinophils at the dermal base. Collagen IV was detected at the dermal floor, and direct immunofluorescence showed linear IgG, IgA, and C3 deposits at the basement membrane zone...
June 15, 2020: American Journal of Dermatopathology
Cristina Vico-Alonso, Sara Palencia-Pérez
New England Journal of Medicine, Volume 382, Issue 23, Page 2248-2248, June 2020.
June 4, 2020: New England Journal of Medicine
Miguel Fernando García-Gil, José Ignacio Franco Rubio, Marcial Álvarez-Salafranca, Juan Monte Serrano, Lucia Prieto-Torres
Flame figures represent a characteristic but nondiagnostic histological finding in eosinophilic dermatoses. Some bullous autoimmune diseases with a predominant eosinophilic infiltrate, such as bullous pemphigoid, pemphigoid gestationis, and pemphigus vegetans, may show them. However, it is rare to find them in predominant neutrophilic bullous dermatoses such as linear immunoglobulin A. We present a 60-year-old man with a history of chronic urticaria, which presented a bullous disease after an acute parvovirus B19 infection...
May 28, 2020: American Journal of Dermatopathology
Vanthida Huang, Nicola A Clayton, Kimberly H Welker
Glycopeptides, such as vancomycin and teicoplanin, are primarily used in the treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections, such as cellulitis, endocarditis, meningitis, pneumonia, and septicemia, and are some of the most commonly prescribed parenteral antimicrobials. Parenteral glycopeptides are first-line therapy for severe MRSA infections; however, oral vancomycin is used as a first-line treatment of Clostridioides difficile infections . Also, we currently have the longer-acting lipoglycopeptides, such as dalbavancin, oritavancin, and telavancin to our armamentarium for the treatment of MRSA infections...
April 21, 2020: Pharmacy (Basel, Switzerland)
Mai Endo, Mikio Ohtsuka, Jun Yamagami, Toshiyuki Yamamoto, Keiji Iwatsuki
No abstract text is available yet for this article.
April 16, 2020: European Journal of Dermatology: EJD
Sofanit A Dessie, Davinder Singh, Varun Dobariya, Derek Evans, Peimei He
Linear immunoglobulin A (IgA) bullous dermatosis (LABD) presents as a rare autoimmune disease that can either occur spontaneously or induced by certain drugs, the most common of which is vancomycin. LABD is a subepidermal blistering disease that is diagnosed by detecting linear IgA bands along the basement membrane. We present a case of a 59-year-old man with worsening blistering skin rash who was treated with vancomycin and piperacillin-tazobactam for pneumonia.
March 4, 2020: Curēus
Emanuele Cozzani, Giovanni Di Zenzo, Giulia Gasparini, Adele Salemme, Arianna Fay Agnoletti, Camilla Vassallo, Marzia Caproni, Emiliano Antiga, Angelo V Marzano, Riccardo Cavalli, Corrado Ocella, Clara de Simone, Aurora Parodi
Linear IgA bullous dermatosis (LABD) is characterized by presence of multiple IgA autoantibodies, and a comparatively lesser number of IgG antibodies, directed against different hemidesmosomal antigens. The main autoantigens are LAD-1, LABD-97, BP180 and BP230, type VII collagen and laminin 332. We retrospectively studied the serology of 54 Italian patients with LABD using enzyme-linked immunosorbent assay (ELISA), immunoblotting assay, and indirect immunofluorescence on monkey oesophagus and salt-split skin...
February 3, 2020: Acta Dermato-venereologica
Htay Phyu, Takaaki Kobayashi, Prerna Rastogi, Christine Cho
No abstract text is available yet for this article.
December 9, 2019: BMJ Case Reports
Emilio Vives Ricoma, Mahfoud El Uali Abeida, María Jesús Viso Soriano, Rafael Fernández Liesa
No abstract text is available yet for this article.
November 25, 2019: Acta Otorrinolaringológica Española
Hristina Momcilo Stamenkovic, Dragana Lazarevic, Tatjana Stankovic, Jelena Vojinovic, Branislav Lekic, Aleksandar Marinkovic, Martina Bosic
Linear IgA dermatosis (LAD) is a rare autoimmune disorder in children. A 9-year-old boy was presented with blisters on the intact skin (face, body, arms, hands, soles, perigenital and perianal area) after amoxicillin treatment. Systemic corticosteroids and dapsone treatment for 6 weeks was successful. Clinical and immunofluorescence examinations are most important for differentiation of LAD and other drug-induced bullous dermatoses. They enable an early introduction of proper therapy.
November 21, 2019: Dermatologic Therapy
Shruti Agrawal, Urmi Khanna, Anthony P Fernandez, Mahwish Irfan, Joshua Arbesman
No abstract text is available yet for this article.
November 6, 2019: American Journal of Gastroenterology
Nadine S Maalouf, Dominique Hanna
No abstract text is available yet for this article.
November 2019: JAAD Case Reports
Puran Gurung, Azaharry Yaakub, Priya Patel, Arjun Ramaiya, Eunice Tan
No abstract text is available yet for this article.
October 2019: JAAD Case Reports
Juliet Schurder, Pauline Morel, Julie Blanc, Maëva Clerté, Christophe Ridel, Maxime Touzot
Vancomycin is a widely used antibiotic in hemodialysis patients. The main complications include renal toxicity and skin lesions. Herein, we report the case of a 29-year-old hemodialysis patient who presented a bullous pruriginous dermatosis after vancomycin treatment. A skin biopsy revealed a linear IgA bullous dermatosis (LABD). This is a rare form of dermatosis and is either idiopathic or more likely vancomycin-induced. Similarities in the molecular structure of vancomycin and epidermal basement membrane glycoproteins could explain the auto-immune response...
October 2019: Hemodialysis International
C Colmant, A Camboni, V Dekeuleneer, L Marot, C Dachelet, M Baeck
Angioimmunoblastic T-cell lymphoma (AITL) is an aggressive form of peripheral T-cell lymphoma, characterised by systemic symptoms, diffuse lymphadenopathy, hepatosplenomegaly and immunodysregulation. Half of AITL is associated with cutaneous symptoms, but only few cases with bullous eruption have been described. Association with a linear IgA dermatosis is extremely rare. Linear IgA dermatosis can be idiopathic, or linked with drug intake or neoplastic disorders. Some cases of linear IgA dermatosis presenting as toxic epidermal necrolysis (TEN) have been described, most of them being drug induced...
September 3, 2019: Journal of Cutaneous Pathology
Maryam Saleem, Hassaan Iftikhar
Linear immunoglobulin A (IgA) bullous dermatosis, also known as linear IgA disease, is a rare disorder with an incidence of about 0.5 to 2.3 cases per million individuals per year. In most of the cases, the cause is unknown; however, 50% of the cases are drug-induced. The disease has bimodal age predilection and occurs in children up to the age of 10 years and in adults usually after the age of 60 years. Common drugs that have been known to cause this disease include vancomycin, lithium, amiodarone, captopril, and some of the nonsteroidal anti-inflammatory agents...
June 6, 2019: Curēus
Joshua R Bakke, Alexandra Chantara, Joshua Cash, Kristopher R Fisher
No abstract text is available yet for this article.
August 7, 2019: Journal of Cutaneous Pathology
Giulia Tadiotto Cicogna, Martina Ferranti, Daniele Vaccari, Mauro Alaibac
A 68-year-old woman was referred to the unit of dermatology for a large basal cell carcinoma on the chin. She was treated with imiquimod cream 5%, and 4 weeks after she developed isolated and grouped tense serum-filled vesicles and bullae on lips, nose, scalp, ankles and lumbar area, and then expanded to the whole body. Histological examination was consistent with a subepidermal bullous dermatosis. Moreover, direct immunofluorescence showed linear deposition of IgA at the basement membrane zone supporting the diagnosis of linear IgA bullous dermatosis (LABD)...
July 19, 2019: BMJ Case Reports
Naoko Kanda, Nanami Nakadaira, Yohei Otsuka, Norito Ishii, Toshihiko Hoashi, Hidehisa Saeki
We report the case of a 59-year-old Japanese woman who developed linear IgA bullous dermatosis during treatment for ulcerative colitis that manifested as pruritic vesicles with erythema on the trunk and scalp. Histopathological examination revealed subepidermal bulla with neutrophil and eosinophil infiltration in the upper dermis. Direct immunofluorescence revealed linear IgA deposits at the basement membrane zone, and indirect immunofluorescence using split skin revealed IgA reaction to the epidermal side (lamina lucida type)...
July 18, 2019: Australasian Journal of Dermatology
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