Mohammad Nabavi, Afshin Rezaeifar, Ali Sadeghinia, Saba Arshi, Sima Bahrami, Mohammad Hassan Bemanian, Morteza Fallahpour, Sima Shokri, Zahra Vakilazad
Linear IgA bullous dermatosis (LABD) is a rare autoimmune blistering disease that may be triggered by some diseases and medications. For the latter one, non-steroidal anti-inflammatory drugs (NSAIDs) have been identified as one of the potential causative agents to develop LABD. Here, a rare case of drug-induced LABD is introduced. A 13-month-old Iranian boy presented with a history of generalized blisters, displaying the classic "string of pearls" sign who was eventually diagnosed as a case of LABD...
October 18, 2020: Iranian Journal of Allergy, Asthma, and Immunology
Claire J Wiggins, Susan Y Chon
Adverse medication side effects are not uncommon in the inpatient setting, where polypharmacy is the norm. Linear IgA bullous dermatosis (LABD) can be a cutaneous side effect of commonly used inpatient medications, such as vancomycin. Symptoms of LABD can be severe, and proper recognition of this drug-induced disease is important to ensuring proper treatment, including the removal of the inciting agent. This report describes a case of vancomycin-associated LABD in a 66-year-old man and the proper management of drug-induced LABD...
August 26, 2020: Proceedings of the Baylor University Medical Center
C Guarneri, M Ceccarelli, L Rinaldi, B Cacopardo, G Nunnari, F Guarneri
Helicobacter pylori is a Gram-negative bacterium identified for the first time about 30 years ago and commonly considered as the main pathogenic factor of gastritis and peptic ulcer. Since then, it was found to be associated with several gastrointestinal and extra-gastrointestinal diseases. Helicobacter pylori is also associated with many skin disorders including, but not limited to, chronic urticaria, rosacea, lichen planus, atopic dermatitis, psoriasis, pemphigus vulgaris, vitiligo, primary cutaneous MALT-type lymphoma, sublamina densa-type linear IgA bullous dermatosis, primary cutaneous marginal zone B-cell lymphomas and cutaneous T-cell pseudolymphoma...
December 2020: European Review for Medical and Pharmacological Sciences
Calogero Pagliarello, Claudio Feliciani, Carlo Renè Girardelli
No abstract text is available yet for this article.
December 16, 2020: JAMA Dermatology
Vanessa Migliarino, Alberto Di Mascio, Irene Berti, Andrea Taddio, Egidio Barbi
A 3-year-old boy presented with a 5-day history of bullous skin lesions localised mainly in the upper and lower limbs and in the genital region (figure 1). Lesions were not pruritic nor painful and showed a central crust. There was no family history of skin disorders or autoimmune diseases. The child never had fever and his physical examination was otherwise unremarkable. edpract;archdischild-2020-319179v1/BLKF1F1BLK_F1Figure 1Bullous skin lesions forming around a central crust, localised in the upper and lower limbs...
November 19, 2020: Archives of Disease in Childhood. Education and Practice Edition
J Raymond Go, Omar M Abu Saleh
New England Journal of Medicine, Volume 383, Issue 16, Page 1577-1577, October 2020.
October 15, 2020: New England Journal of Medicine
Stanislav Khil'chenko, Katharina Boch, Nina van Beek, Artem Vorobyev, Detlef Zillikens, Enno Schmidt, Ralf J Ludwig
Pemphigus and pemphigoid diseases are organ-specific autoimmune diseases of the skin and/or mucous membranes, which are caused by autoantibodies targeting structural proteins of the skin. In other autoimmune diseases, a high prevalence of primary antibody deficiencies was noted. Conversely, a high prevalence of autoimmune diseases is reported in patients with primary antibody deficiencies. With the exception of one study, pointing toward a decrease of IgG in pemphigus patients, with a relative enrichment of IgG4, serum immunoglobulin (Ig) concentrations had not been studied in pemphigus and pemphigoid...
2020: Frontiers in Medicine
Dimitra Koumaki, Vasiliki Koumaki, Sotirios Boumpoucheropoulos, Alexander Katoulis, Charikleia Kouvidou, Maria Stefanidou, Panagiotis P Bitados, Ludmila Baltaga, Orestis Miaris, George Evangelou, Sabine Elke Krueger-Krasagakis, Konstantinos Krasagakis
We report a case of linear IgA bullous dermatosis, a rare autoimmune blistering disorder that usually presents with the abrupt onset of tense bullae. We also emphasize the importance of direct immunofluorescence for the definitive diagnosis.
July 2020: Clinical Case Reports
Sofia Raiber, Tanya Sezin, Christian D Sadik, Reuven Bergman, Emily Avitan-Hersh
Neonatal autoimmune subepidermal blistering disease is rare. Mucosal involvement is more common in neonatal linear immunoglobulin A (IgA) bullous dermatosis. We describe a neonate with subepidermal cutaneous blistering disease with severe laryngeal and esophageal involvement leading to acute respiratory distress. Histopathology demonstrated a subepidermal blister with neutrophils and eosinophils at the dermal base. Collagen IV was detected at the dermal floor, and direct immunofluorescence showed linear IgG, IgA, and C3 deposits at the basement membrane zone...
June 15, 2020: American Journal of Dermatopathology
Cristina Vico-Alonso, Sara Palencia-Pérez
New England Journal of Medicine, Volume 382, Issue 23, Page 2248-2248, June 2020.
June 4, 2020: New England Journal of Medicine
Miguel Fernando García-Gil, José Ignacio Franco Rubio, Marcial Álvarez-Salafranca, Juan Monte Serrano, Lucia Prieto-Torres
Flame figures represent a characteristic but nondiagnostic histological finding in eosinophilic dermatoses. Some bullous autoimmune diseases with a predominant eosinophilic infiltrate, such as bullous pemphigoid, pemphigoid gestationis, and pemphigus vegetans, may show them. However, it is rare to find them in predominant neutrophilic bullous dermatoses such as linear immunoglobulin A. We present a 60-year-old man with a history of chronic urticaria, which presented a bullous disease after an acute parvovirus B19 infection...
May 28, 2020: American Journal of Dermatopathology
Vanthida Huang, Nicola A Clayton, Kimberly H Welker
Glycopeptides, such as vancomycin and teicoplanin, are primarily used in the treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections, such as cellulitis, endocarditis, meningitis, pneumonia, and septicemia, and are some of the most commonly prescribed parenteral antimicrobials. Parenteral glycopeptides are first-line therapy for severe MRSA infections; however, oral vancomycin is used as a first-line treatment of Clostridioides difficile infections . Also, we currently have the longer-acting lipoglycopeptides, such as dalbavancin, oritavancin, and telavancin to our armamentarium for the treatment of MRSA infections...
April 21, 2020: Pharmacy (Basel, Switzerland)
Mai Endo, Mikio Ohtsuka, Jun Yamagami, Toshiyuki Yamamoto, Keiji Iwatsuki
No abstract text is available yet for this article.
April 16, 2020: European Journal of Dermatology: EJD
Sofanit A Dessie, Davinder Singh, Varun Dobariya, Derek Evans, Peimei He
Linear immunoglobulin A (IgA) bullous dermatosis (LABD) presents as a rare autoimmune disease that can either occur spontaneously or induced by certain drugs, the most common of which is vancomycin. LABD is a subepidermal blistering disease that is diagnosed by detecting linear IgA bands along the basement membrane. We present a case of a 59-year-old man with worsening blistering skin rash who was treated with vancomycin and piperacillin-tazobactam for pneumonia.
March 4, 2020: Curēus
Emanuele Cozzani, Giovanni Di Zenzo, Giulia Gasparini, Adele Salemme, Arianna Fay Agnoletti, Camilla Vassallo, Marzia Caproni, Emiliano Antiga, Angelo V Marzano, Riccardo Cavalli, Corrado Ocella, Clara de Simone, Aurora Parodi
Linear IgA bullous dermatosis (LABD) is characterized by presence of multiple IgA autoantibodies, and a comparatively lesser number of IgG antibodies, directed against different hemidesmosomal antigens. The main autoantigens are LAD-1, LABD-97, BP180 and BP230, type VII collagen and laminin 332. We retrospectively studied the serology of 54 Italian patients with LABD using enzyme-linked immunosorbent assay (ELISA), immunoblotting assay, and indirect immunofluorescence on monkey oesophagus and salt-split skin...
February 3, 2020: Acta Dermato-venereologica
Htay Phyu, Takaaki Kobayashi, Prerna Rastogi, Christine Cho
No abstract text is available yet for this article.
December 9, 2019: BMJ Case Reports
Emilio Vives Ricoma, Mahfoud El Uali Abeida, María Jesús Viso Soriano, Rafael Fernández Liesa
No abstract text is available yet for this article.
November 25, 2019: Acta Otorrinolaringológica Española
Hristina Momcilo Stamenkovic, Dragana Lazarevic, Tatjana Stankovic, Jelena Vojinovic, Branislav Lekic, Aleksandar Marinkovic, Martina Bosic
Linear IgA dermatosis (LAD) is a rare autoimmune disorder in children. A 9-year-old boy was presented with blisters on the intact skin (face, body, arms, hands, soles, perigenital and perianal area) after amoxicillin treatment. Systemic corticosteroids and dapsone treatment for 6 weeks was successful. Clinical and immunofluorescence examinations are most important for differentiation of LAD and other drug-induced bullous dermatoses. They enable an early introduction of proper therapy.
November 21, 2019: Dermatologic Therapy
Shruti Agrawal, Urmi Khanna, Anthony P Fernandez, Mahwish Irfan, Joshua Arbesman
No abstract text is available yet for this article.
November 6, 2019: American Journal of Gastroenterology
Nadine S Maalouf, Dominique Hanna
No abstract text is available yet for this article.
November 2019: JAAD Case Reports
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