Benjarath Pupacdi, Christopher A Loffredo, Anuradha Budhu, Siritida Rabibhadana, Vajarabhongsa Bhudhisawasdi, Chawalit Pairojkul, Wattana Sukeepaisarnjaroen, Ake Pugkhem, Vor Luvira, Nirush Lertprasertsuke, Anon Chotirosniramit, Chirayu U Auewarakul, Teerapat Ungtrakul, Thaniya Sricharunrat, Suleeporn Sangrajrang, Kannika Phornphutkul, Paul S Albert, Sungduk Kim, Curtis C Harris, Chulabhorn Mahidol, Xin Wei Wang, Mathuros Ruchirawat
Thailand is among countries with the highest global incidence and mortality rates of hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (iCCA). While viral hepatitis and liver fluke infections have been associated with HCC and iCCA, respectively, other environmental risk factors, overall risk factor commonality and combinatorial roles, and effects on survival have not been systematically examined. We conducted a TIGER-LC consortium-based population study covering all high-incidence areas of both malignancies across Thailand: 837 HCC, 1474 iCCA, and 1112 controls (2011-2019) were comprehensively queried on lifelong environmental exposures, lifestyle, and medical history...
May 18, 2024: International Journal of Cancer. Journal International du Cancer